Causal Factors Research Articles

Identification and characterization of NMNAT1 gene mutations in an Iranian patient with Leber congenital amaurosis 9.

The discovery of compound heterozygous NMNAT1 mutations (c.245T>C; p.Val82Ala and c.575A>G; p.Asp192Gly) provides a genetic explanation for Leber congenital amaurosis 9 in an Iranian patient. The proband's symptoms-including severe visual impairment, nystagmus, night blindness, and retinal degeneration-align with Leber congenital amaurosis 9 clinical features. This case underscores the value of exome-sequencing in diagnosing rare genetic disorders and highlights its role in guiding personalized genetic counseling and potential treatments. Leber congenital amaurosis is a severe early-onset inherited retinal dystrophy. This study delves into the genetic basis of Leber congenital amaurosis, pinpointing compound heterozygous mutations in the NMNAT1 gene as significant causative factors. While one mutation validates previous findings (c.245T>C; p.Val82Ala), the second (c.575A>G; p.Asp192Gly) proves novel, expanding the genetic landscape of Leber congenital amaurosis 9. Both mutations, inherited independently from nonconsanguineous parents, contribute to the intricate genetic basis of light on Leber congenital amaurosis 9 in this case. The identified mutations shed light on Leber congenital amaurosis genetics in the Iranian population, showcasing the efficacy of exome-sequencing for molecular diagnoses in hereditary retinal degeneration. These findings provide valuable insights for tailored genetic counseling and potential therapeutic interventions.

Total Ankle Arthroplasty Incision Management: What Matters? A Systematic Review

Modern advancements in total ankle arthroplasty techniques and implants have increased the popularity of this treatment for ankle osteoarthritis. The preeminent approach for ankle replacement involves an anterior incision, however, wound complications with this approach provide a persistent challenge to surgeons. The present study was conducted to synthesize current data on ankle replacement wound complications via an anterior approach. A systematic review was completed including studies published from 1993 to present that employed an anterior approach and had precise criteria for wound healing and revisions. Twenty-nine studies, with level 3 to 4 evidence and moderate to serious bias, were included for a total of 6,986 ankle arthroplasties. The rate of wound healing without any complication was 90.38%. Minor dehiscence occurred in 6.00% of cases, while major wounds or infections occurred in 3.62%. Across 2,966 implants, the rate of major wounds or infections decreased from 7.03% before 2013 to 4.75% after 2013 (p = 0.034). Limited comparisons involving simple suture closure to various adjunct wound management techniques including negative pressure wound therapy, 2-octyl cyanoacrylate, platelet-rich plasma, dehydrated human amniotic membrane allograft, non-invasive skin expansion strips, compression wound dressings, tranexamic acid, surgical helmets, tourniquets, ankle arthrodesis, and lateral approach ankle arthroplasty, yielded non-significant differences (p > 0.18). Therefore, contemporary techniques, patient selection, and current implants may be leading to better soft tissue healing. As ankle replacement continues to surge in popularity, further research is needed to evaluate causative factors in successful anterior incision healing. Level of Clinical Evidence3

Fuzzy Logic-Based Landslide Susceptibility Mapping in Earthquake-Prone Areas: A Case Study of the Mila Basin, Algeria

Abstract —This research focuses on analyzing landslides triggered by a moderate earthquake (Mw = 4.9) in the northeastern region of the Mila province, which resulted in significant damage and economic losses in the El Kherba district and Grarem Gouga city. Through an extensive field-based investigation, a comprehensive inventory of landslides has been compiled. To assess the susceptibility to landslides triggered by seismic activity, a GIS-based fuzzy logic model was employed. The model incorporates various input factors, such as lithology, slope angle, normalized difference vegetation index (NDVI), distance from rivers and roads, precipitation, and seismic hazard, which is shown on a map. The study compares the performance of different fuzzy operators and gamma values and determines that using fuzzy gamma operators with a gamma value of 0.8 yields a satisfactory consistency with the distribution of landslides. Moreover, incorporating the map of seismic hazard as a causative factor enhances the accuracy of landslide susceptibility mapping. This study underscores the utility of the fuzzy logic model in disaster management and the planning of development activities.

Extent and drivers of land productivity degradation at the territorial level in Eastern DR Congo

Land degradation is a global environmental problem that affects the livelihoods of communities. Understanding the extent and causative factors of this phenomenon is important to design the cause-targeted strategies to cope with this problem. This study aimed to assess the effects of biophysical and socio-economic factors on the occurrence of land productivity degradation at the territorial level in Eastern DR Congo, using the Kalehe territory as a case study. The land productivity dynamics were determined based on the trend analysis of Landsat-based NDVI annual composites over the 1987-2020 period. Additionally, a binary logistic regression model was developed to identify the determinant factors and to map the susceptibility of this degradation at the territorial level. The results revealed that 31.25% (1303.175 km2) of the territory had experienced a decrease in land productivity, with 10.8% (453.83 km2) characterized by a significant decrease at the confidence level of 90%, representing the hotspots area of land productivity degradation where conservation actions should be prioritized. This decrease in land productivity is location-specific as it depends on the land cover types and health zones. It is likely to occur at high altitudes, in areas close to artisanal mining sites, rivers, and administrative centers. These results imply that policy interventions to cope with the problem of land productivity degradation should be developed following the heterogeneity of the landscape, and sustainable land management practices that take into account both the biophysical and socio-economic drivers of land degradation should be implemented in this region to achieve the land degradation neutrality by 2030.

Novel heterozygous mutation of CACNA2D1 gene in a Chinese family with arrhythmia

BackgroundPrimary electrical disorders (PEDs) are a group of cardiac rhythm abnormalities that occur in the absence of detectable structural heart disease and are a significant cause of sudden cardiac death (SCD). The initiation of cardiac muscle contraction and relaxation is orchestrated by the action potential (AP), generated through ionic changes across the membrane. Mutations in the AP-related gene CACNA2D1 have been identified as a causative factor for PED.MethodsWe recruited a Chinese family with a history of arrhythmia. The proband has experienced palpitations and chest tightness for over 40 years, with symptoms worsening over the past year. Whole exome sequencing (WES) was used to determine the genetic etiologies in this family.ResultsA novel heterozygous missense mutation (NM_000722.3: c.1685G > C;p.G562A) of CACNA2D1 gene was detected. Genotyping of the proband’s parents indicated that the arrhythmia phenotype in the proband was caused by a de novo mutation.ConclusionsWES was utilized to explore the genetic etiology in a family with arrhythmia, leading to the identification of a novel mutation in the CACNA2D1 gene. This study not only expands the mutation spectrum of the CACNA2D1 gene but also contributes to genetic counseling and clinical diagnosis for this family.

Efficacy of B-Lynch Compression Suture for Control of Primary Post-Partum Hemorrhage

OBJECTIVES This study aimed to evaluate the efficiency of the B-Lynch compression suture for primary post-partum hemorrhage control. METHODOLOGY It is a prospective cross-sectional study performed for two years, i.e., 1 November 2021 to 31 October 2023, at the Department of Obstetrics and Gynaecology in a tertiary care hospital. This study included 65 study cases out of 23,964 with primary post-partum hemorrhage (PPH) due to uterine atony during cesarean delivery not responding to pharmacological treatment and was managed by applying B-Lynch compression sutures. The amount of blood loss, demographic characteristics, birth weight of babies, causative factors, and other related complications were studied in such selected cases. RESULTSB-Lynch compression suture presented a success rate of 97% in the present study. 52% had blood loss of 1000-1500ml, 29% had loss between 1501-2000ml and 18% had 2001-2500ml blood loss. 6% had wound gaping, 10.7% had a fever, and 8% had more than seven days stay in hospital, and wound infections were noted. CONCLUSION Our study concluded that the B-Lynch compression suture had a success rate of 97% in the management of primary post-partum hemorrhage, with few post-operative complications. The current research demonstrates the efficacy of B-Lynch as a lifesaving, easy, effectual technique that avoids hysterectomy and thus avoids heavy blood loss.

Physiological deterioration prior to in-hospital cardiac arrest: What does the National Early Warning Score-2 miss?

AimTo determine the frequency with which the National Early Warning Score-2 (NEWS-2) fails to detect physiological deterioration preceding in-hospital cardiac arrest (IHCA). MethodsWe conducted a retrospective observational study of all adult patients (age ≥ 18) who had suffered an IHCA between 1st July 2019 and 31st December 2021 in two large acute hospitals located in an urban centre (Nottingham, UK). Clinical observations and case notes were examined for the period leading up to IHCA events to determine if there was evidence of physiological deterioration which warranted an urgent patient assessment, whether NEWS-2 was triggered, and whether an urgent assessment actually took place. ResultsUrgent assessment was indicated in the lead-up to 126/374 (33.7 %) IHCA cases, and NEWS-2 failed to trigger in 20 of these cases (15.9 %). An urgent assessment took place in 89/106 (84.0 %) cases where NEWS-2 was triggered, and 13/20 (65.0 %) cases where NEWS-2 was not triggered, with the difference in proportions being statistically significant (p = 0.048). Half of cases in which NEWS-2 missed a physiological deterioration were related to a new or rising oxygen requirement. ConclusionsA significant proportion of IHCA events are preceded by clinically important abnormalities in vital signs which are not detected by NEWS-2. This may be a causative factor in some failure-to-rescue events.

Fear of Happiness: Description, Causes and Prevention

Studies in mental health is to increase the positive emotions of the person and to reduce the negative emotions, beliefs and thoughts. Especially after positive psychology, many studies have been carried out to ensure that individuals have positive emotions. However, in recent studies, it has been determined that individuals avoid not only negative emotions but also positive emotions. Thus, you suppress your positive emotions because of fear of happiness. The individual's beliefs and cultural values also affect mental health. The person is afraid of being happy because of these beliefs and cultural values. Fear of happiness is the avoidance of happines. When people believe thet unhappiness will come immediately after happiness or that the environment will be harmed after being happy, fear of happiness occurs. Fear of happiness harms both the mental health and social relations. Morever, fear of happiness is associated with alexithymia, anxiety, stress, fear of compassion, antisocial, cognitive distortions related to relationships, panic disorder and especially depression. It is extremely important to know and define the fear of happiness for an effective treatment interventions. Fear of happiness rests in maladaptive schemas in early life, not meeting their needs warmly and sincerely in childhood, punishing them when they experience positive emotions, and growing up in a family with unhealthy family patterns. In this study, it is aimed to define fear of happiness, to determine the protective and risk factors, to determine the causative factors, to explain the related concepts, and so to raise awareness about fear of happiness.

Development of prediction model for risks of musculoskeletal chronic lumbopelvic pain in Indian women

Chronic lumbopelvic pain (CLPP) and its associated disabilities significantly affect women's social, professional, and personal lives. However, the specific factors contributing to CLPP in women remain unclear. To address this gap, this prospective cross-sectional study aims to identify the risk factors predicting CLPP in women and develop a prediction model that can predict CLPP in women. The study was conducted across Delhi, India, where free health camps were held, and 2400 women were assessed. Among the assessed individuals, the study revealed a high prevalence rate of CLPP among Indian women, standing at 70.4%. Seven risk factors namely, hamstring muscle tightness (> 20° on passive knee extension test), increased lumbar lordosis (> 11.5 cm of the lumbar lordotic index), reduced hip flexibility (> 15 cm on bent knee fallout test), altered foot posture (≥ 20 on foot posture index score), increased perception of psychological stress (> 25 on cohen’s perceived stress scale-10 score), reduced physical activity level (< 475 metabolic/minute on international physical activity questionnaire) and reduced performance of transversus abdominis muscle (≤ 5 on deep muscle contraction scale score) strongly predict the risks of CLPP in women. Identifying these risk factors is crucial for effectively preventing and managing CLPP symptoms, especially considering its high prevalence among Indian women. Health professionals should prioritize raising awareness about CLPP and its causative factors, as well as implementing strategies for early detection and intervention.

NARRATIVE REVIEW: INCIDENCE, CAUSES AND INTERVENTION STRATEGIES OF MEDICATION ERRORS TO IMPROVE CHEMOTHERAPY SERVICES IN HOSPITALS

Medication errors (MEs) are medication errors that have the potential to harm patients during treatment or care. Cancer care is a complex and interconnected system and many errors can be catastrophic. ME in antineoplastic drugs have the potential to cause permanent injury and even death. Evaluation measures of ME incidence in Indonesia are still not optimally carried out, thus leading to the need for a good understanding of the potential ME incidence, especially in cancer patient care. A good understanding of the incidence of medication errors will encourage preventive efforts against the potential occurrence of ME. This narrative review aims to provide information related to the incidence of ME in the Chemotherapy department at the hospital, the causative factors, and the handling and prevention efforts. Scientific information searches were conducted on the PubMed and Google Scholar databases for the period 2012-2022. The results showed that the incidence of ME mostly occurred in the prescription phase, namely in the form of dosage errors (45–59.3%), incomplete prescriptions (43–45.5%), drug frequency errors (30.4%), and errors in patient name, age, and diagnosis data (22.5%). Several aspects contributing to the occurrence of ME were identified, including work procedures, staff, organizational systems, and staff understanding of medication regimens. This study concluded that there is a need to regulate and evaluate several aspects, including work procedures, availability of auxiliary systems, and increasing the capacity of human resources involved. This may prevent the occurrence of ME.

NLRP3 Inflammasome in the Pathogenesis of Miscarriages

Despite significant advances in prenatal medicine, spontaneous miscarriage remains one of the most common and serious pregnancy complications, affecting an increasing number of women. Since many aspects of the pathogenesis of spontaneous miscarriage remain unexplained, the aim of this study has been to assess the involvement of the NLRP3 inflammasome as a potential causative factor. The concentrations of NLRP3, IL-1β, IL-18, and cytochrome C in the serum of patients after miscarriage were measured by means of the immunoenzymatic method. In the placental tissue, the expression of NLRP3, IL-1β, IL-18, and Caspase-1 as well as that of the classical apoptosis biomarkers Fas, FasL, Bcl-2, and Ca was evaluated by means of immunohistochemistry techniques. Additionally, in whole blood, the concentrations of elements crucial for pregnancy progression, such as Ca, K, Mg, and Na, were examined by means of the ICP-OES method. Significantly higher concentrations of NLRP3 and IL-18 were demonstrated in the serum of patients with miscarriage as compared to the control group. In the placental tissue samples, a higher expression of IL-1β, IL-18, and Caspase-1 proteins was noted in women who had experienced miscarriage as compared to the control group. At the same time, a significantly lower expression of FasL and Bcl-2 proteins as well as Ca deposits was observed in women after miscarriage as compared to those with a normal pregnancy outcome. Significantly lower concentrations of Ca and K were recorded in the blood of patients with spontaneous miscarriage as compared to pregnant women. The analysis of the results x indicated a greater involvement of the inflammasome in women with spontaneous miscarriage associated with oxidative–antioxidative imbalance than in the case of miscarriage related to NET formation. Our research has provided evidence for the involvement of the inflammasome in the process of spontaneous miscarriage and identifies a new direction for diagnostics that includes NLRP3 as a preventive element in prenatal care, particularly in light of the steadily declining number of pregnancies and the increasing number of reproductive failures.

THE POPULATION OF MILA FACING THE EARTHQUAKE OF AUGUST 07, 2020

The surge in urbanization within regions vulnerable to seismic activity poses a significant escalation in seismic risks. Effective mitigation strategies, reliant on improved architectural practices and behavioral adaptations, are imperative to curtail the toll of seismic events. Seismic vulnerability, intricately intertwined with seismic hazard, building conditions, and populace preparedness, underscores the need for comprehensive risk assessment. Although studies elucidating seismic risk knowledge and behaviors are scant in Algeria, they are more prevalent in Mediterranean regions. This paper delves into the examination of risk culture, discerning both direct and indirect causative factors behind the seismic disaster that befell Mila on August 7, 2020.Employing a research methodology that integrates the method Did You Feel It (DYFI USGS ) with a survey model used in Beirut, Lebanon.The findings offer notable insights for two principal reasons. Firstly, local perceptions of the seismic event's severity surpassed estimates by the US Geological Survey (USGS). Secondly, despite the relatively minor magnitude of seismic effects in the El Kherba neighborhood, the populace displayed inadequate preparedness for future earthquakes. Additionally, site-specific factors exerted substantial influence on crisis outcomes. In this context, the preparedness of Algerian society for seismic risks depends on understanding the phenomenon, recognizing associated hazards, and identifying available resources. Contribution: this study serves as a pivotal resource for fostering proactive local population preparedness and mitigating natural risks. Furthermore, it seeks to augment the efficacy of policies aimed at managing natural disaster risks in Algeria.

A Critical Analysis of Food in Health and Disease

The effect of food factors on health status has been recognized since antiquity.The human body cAmong Trayopsthambhas food plays a major role in health and disease. On critical analysis, it is observed that more than 50 percent of the causative factors related to food are responsible for the production of different disease conditions. Hence the authorities of Ayurveda have prescribed certain rules related to diet and dietetics. In view of the painful diseases with irregular dieting, a wise person who has control over his senses should take wholesome food in proper quantity and in proper time. This is a golden rule for all and ever. In all human beings in every stage i.e. for the maintenance of health, for manifestation of diseases, during treatment, during convalescence, in the preoperative and in post-operative stages food plays an important role. Keeping all these factors in view the present study has been taken up to bring out comprehensive information about food in health and disease

The Correlation Between Academic Performance in CELE-Related Subjects and CELE Performance Among Bachelor of Science in Civil Engineering Students at Nueva Ecija University of Science and Technology

This study investigated the relationship between academic performance in CELE-related subjects and CELE performance among Bachelor of Science in Civil Engineering (BSCE) students at Nueva Ecija University of Science and Technology (NEUST). A quantitative research design employing correlation analysis was utilized. The sample consisted of 322 random BSCE students who had taken CELE in the last five exam dates. The results revealed a significant positive correlation between students' performance in their Mathematics, Surveying, and Transportation Engineering (MSTE) and Structural Engineering and Construction (SEC) subjects during their BSCE program and their corresponding achievements on the PRC board exam. However, no significant correlation emerged between students' performance in their Hydraulics and Geotechnical Engineering (HGE) subjects during their BSCE program and their performance on the corresponding section of the PRC board exam. Additionally, the results indicated a significant positive correlation between students' weighted GPAs during their BSCE program and their performance on the PRC board exam.These findings suggest that strong academic performance in CELE-related subjects is associated with success on the CELE, highlighting the importance of a well-aligned curriculum and educational strategies. However, further research is needed to explore causative factors and provide a more comprehensive understanding of the dynamics influencing CELE performance.

Study on the Influencing Factors of Heart Disease

With the continuous development of technology and scientific research, people are constantly exploring the mysteries of the universe and human. Since ancient times, most people have died under various incurable diseases, which has led to a need for more knowledge about diseases to help humans resist diseases and help people explore the world to the next level. According to years of data statistics, cardiovascular and cerebrovascular diseases are one of the diseases with the highest mortality rate, and heart disease is included in it. According to statistics, around 695000 people died from heart disease in 2021, which is an extremely large number, so this paper needs to conduct research on heart disease more. This experiment aims to identify and analyze data related to heart disease, as well as use correlation methods to discover the impact of different factors that contribute to heart disease. By doing so, experimental results can be obtained and conclusions can be drawn regarding the research topic. Through experimental results, it can help people understand the different degrees of influence of the causative factors of heart disease on heart disease, maintain good lifestyle habits in daily life, and provide some tips and assistance for medical treatment. And this experiment can provide some reference for future research on heart disease and contribute to the development of drugs and medical technology.

Urinary Incontinence in Nulliparous Female Elite Athletes: A Mixed Methods Exploration.

Urinary incontinence (UI) occurs in 40-50% of nulliparous female elite athletes. However, causative factors, management, and perceptions of UI in this population are suboptimally understood. The objectives of this study were to (1) identify factors that precipitate UI in nulliparous female elite athletes and (2) explore management strategies for UI and its effect on sports performance and quality of life. This was a cross-sectional, mixed-methods study in Division 1, college-aged nulliparous female athletes. Surveys assessed demographics, sport characteristics, relevant medical history, bladder symptoms during exercise, and validated genitourinary symptom questionnaires (Lower Urinary Tract Dysfunction Network Symptom Index-29, Female Genitourinary Pain Index). Data were compared between symptomatic athletes (who had ever experienced urinary leakage during exercise) and asymptomatic athletes. Symptomatic athletes discussed their experiences with UI in focus groups. Symptomatic athletes (33/67, 49%) had more asthma (21% vs. 2.9%, P = 0.027) and constipation (15% vs. 0%, P = 0.025), were more sexually active (76% vs. 44%, P = 0.008), and had worse overall urinary symptoms and genitourinary pain than asymptomatic athletes. They described both stress and urgency incontinence precipitated by various factors, including running, jumping, sustained efforts, and stressful situations. Many described voiding frequently before and during exercise. Despite increasing normalization of UI in the female athlete population since the onset of adolescence and variable degrees of bother, interest in improving symptom management was common. Urinary incontinence in nulliparous female elite athletes may be multifactorial given its association with medical, behavioral, exercise-specific, and environmental conditions, which may be explored longitudinally to inform prevention and treatment strategies.

The Kids Heart BioBank: supporting 20 years of patient care and research into CHD.

The cause of most CHD is unknown and considered complex, implicating genetic and environmental factors in disease causation. The Kids Heart BioBank was established in 2003 to accelerate genetic investigations into CHD. Recruitment includes patients undergoing interventions for CHD at The Children's Hospital at Westmead. Informed consent is obtained from parents/guardians, and blood is collected at the time of cardiac intervention from which DNA is extracted and stored. Associated detailed clinical information and a family history are stored in the purpose-designed database. To date, the Kids Heart BioBank contains biospecimens and associated clinical information from over 4,900 patients with CHD and their families. Two-thirds (64.1%) of probands have been included in research studies with 28.9% of participants who underwent genomic sequencing receiving a molecular diagnosis with direct clinical utility. The value of this resource to patients and families is highlighted by the high consent rate (94.6%) and the low withdrawal of consent rate (0.4%). The Kids Heart BioBank has supported many large national and international collaborations and contributed significantly to CHD research. The Kids Heart BioBank is an invaluable resource and, together with other similar resources, the resulting research has paved the way for clinical genetic testing options for CHD patients, previously not possible. With research in the field moving away from diagnosing monogenic disease, the Kids Heart BioBank is ideally placed to support the next chapter of research efforts into complex disease mechanisms, requiring large patient cohorts with detailed phenotypic information.

Clinical characteristics and thrombophilia associated gene variants in Egyptians with unprovoked venous thromboembolism: three centers experience.

Thrombophilias are characterized by excessive venous and arterial thrombosis at regular or unusual sites. It may result from inherited, acquired, or a combination. Hereditary thrombophilia (HT) is detected in 30-40% of patients with thromboembolism. Venous/arterial thrombosis is considered a multifactorial disorder, some patients may have more than one risk factor which may be transient or permanent. Assess the clinical characteristics of patients with unprovoked thromboembolic events and the role of inherited thrombophilia as a causative or additive risk factor. 210 consecutive adult patients with unprovoked thromboembolic events were reviewed in hematology units at three tertiary Egyptian centers between September 2022 and September 2023. The diagnosis of thromboembolic events was confirmed by clinical and radiological findings. Laboratory screening for thrombophilia-associated. Among our patients, 53(25.2%) patients presented with isolated DVT, followed by portal vein thrombosis, 32(15.2%) had a pulmonary embolism, and sagittal sinus thrombosis was developed in 23(10.9%) patients. Younger people who experience spontaneous thromboembolism run the chance of having hereditary thrombophilia; the more mutations discovered, the higher the risk of thrombosis; the lower leg and deep vein thrombosis were the most common sites. Lastly, MTHFR C677T was the most common polymorphism in Egyptians, detected in almost half of the cases.

Analytic Hierarchy Process (AHP)-Based Evaluation of Extremely-Low-Frequency Magnetic Field Contribution Rates

The extremely-low-frequency (ELF) magnetic fields of submarines serve as key characteristics for target detection, with their formation mechanisms being complex and diverse. Effectively manipulating a submarine to reduce its magnetic signature is crucial for enhancing its magnetic stealth capabilities. However, current research on the impact of various causative factors is insufficient. This study proposes a contribution rate assessment method based on the Analytic Hierarchy Process (AHP) model, aiming to provide a theoretical basis for effective manipulation. Initially, a thorough analysis of the threat causes of a submarine’s ELF magnetic fields is conducted, and a corresponding hierarchical threat structure model is established. Subsequently, magnetic field signal characteristics generated by different causes are obtained through simulation, and threat matrices and characteristic matrices are constructed. Finally, the contribution rates of different causative magnetic fields to the total magnetic field are calculated, and the simulation results validate the effectiveness of the method. At the stern detection line, the contribution rate of the wake magnetic field is the highest, reaching 0.7649. Along the radial detection line, the contribution rate of the shaft frequency magnetic field is the highest and gradually decays, eventually falling below the wake magnetic field at 150 m and remaining at an approximately 0.5 contribution rate. This study calculates the contribution rates under different operational conditions and detection scenarios, laying a technical foundation for research on the comprehensive active control strategies of submarine ELF magnetic fields in different scenarios.

Allergy mapping in children with allergic rhinitis in different subjects of the Russian Federation

Given the climatic and geographical location and differences in the change of seasons in the Russian Federation, there is a marked heterogeneity in the representation of respiratory allergens. Obviously, in the case of double or triple sensitization, the diagnosis of its true picture is a difficult task. In such cases, allergy-component analysis is an extremely necessary stage of allergological examination. Purpose of the study: to assess the sensitization spectrum of AR patients in the age group from 3 to 17 years inclusive, living in different regions of the Russian Federation. Comparative analysis of differences in the sensitization spectrum of AR patients in the Republic of Ingushetia in different age groups. The study involved 47 patients, 36 of them were children under 18 years of age: Moscow n = 9 (Central Federal District), Samara n = 8 (Volga Federal District), Magas n = 19 (North Caucasus Federal District, Republic of Ingushetia). Also, 11 patients aged 18 years and older from Magas city took part in the study. The results obtained by ImmunoCAP ISAC and ALEX2 immune solid-phase allergy test were analyzed. The numerical values of the main respiratory allergens were evaluated, in patients with clinical signs of AR in the period from 01.01.2023 to 27.01.2024. The diagnosis of AR was made according to generally accepted criteria for diagnosis. The main causative factor of AR formation is the major allergen of birch pollen (Bet v1). However, for the Central Federal District, heterogeneity of representation in the group of buciferous trees was noted, which should be taken into account when planning allergen-specific immunotherapy. The spectrum of sensitization of children with AR in the North Caucasian Federal District (Magas) differs significantly from the Central and Volga Federal Districts, where the main major allergen of Amb a 1 ragweed pollen forms the etiological basis of AR formation. When comparing patients with AR of different age groups from Magas city, no differences in the sensitization spectrum were found. The results indicate a high degree of importance of allergy-component diagnostics to improve the effectiveness of allergen-specific immunotherapy.