Objective To observe and compare the clinical effect of traditional Chinese medicine (TCM)combined with transurethral resection of prostate(TURP) and simple TURP in treating benign prostatic hyperplasia (BPH). Methods 60 patients with BPH were randomly divided into two groups. The treatment group(n=30) was given the TCM combined TURP and the control group(n = 30) was given TURP alone. The effects were observed.Results Improvement of lower urinary tract symptoms(LUTS), the international prostate symptom score (I-PSS) of the treatment group was better than that of the control group with significant difference (P < 0.01). The time and quantity of bladder irrigation, incidence of bladder spasm, incidence of constipation after operation of the treatment group were less than that of the control group with significant difference(all P <0.05). Catheter retention time,postoperative bleeding, urinary retention were less and had no significant difference between the two groups (all P >0. 05). Conclusion The effect of TCM combined with TURP was significantly superior to that of simple TURP; and adverse reaction after treatment was less than that in the control group. Key words: Benign prostatic hyperplasia; Traditional Chinese medicine; Transurethral resection of prostate