The study aims to investigate the role of family such as lack of parental supervision, lack of connection with childrens, multiple mothering and single parent in student’s drug abuse and its effects on their academic performance in District Mardan of Khyber Pakhtunkhwa, Pakistan. The population of the study comprised of 375 students of University of Engineering & Technology Mardan and Abdul Wali Khan University Mardan. Sample size was drawn with the help of Sekaran’s Magic table. Quota sampling technique was used for distribution of sample size among the selected categories of respondents. The Problem- behavior theory presented by Richard Jessor in 1960s for alcohol abuse and other problem behaviors among students is adopted as a theoretical framework for this study. The primary data was collected with the help ofa three point likert scale, close ended structured questionnaire. Data was analyzed and presented at bi-variate levels using Chi-Square test in order to determine relationship between dependent and independent variables. Among the linked factors: drug abusing parents, high socio-economic status of family, broken family structure, multiple mothering in early age, single parents, lack of family supervision, lack of familial support and lack of family interest in children’s decisions were significantly associated with student’s drug abuse and had a harmful effect on their academic performance. Parents should take keen interest in the activities of their children’swhich will be having fruitful outcomes for children’s. Parents should also monitor the routine activities of their children’s which will result in prevention of deviant behaviors among students. Henceforth, close communication among parents and children’s is required to identify and resolve issues pertaining to social life as a result children’s will feel home which will prevent them from drug abuse and other severe negative tendencies.