Water quality condition and trend are important indicators of the impact of land use on the environment, as degraded water quality causes unwelcome changes to ecosystem composition and health. These concerns extend to the sea, where discharges of nutrients, sediments and toxicants above natural levels are unwelcome, particularly when they drain to the Great Barrier Reef World Heritage Area and other coastal waters of Queensland. Sugarcane is grown in 26 major river catchments in Queensland, most in environmentally sensitive areas. This puts pressure on the Queensland Sugar Industry to manage the land in ways that have minimum adverse off-site impacts. Sugar researchers including CRC Sugar have been associated with water quality studies in North Queensland. These include investigations and reviews to assess the role of groundwater as a pathway for nitrate loss from canelands in the Herbert Catchment, to find causes of oxygen depletion in water (including irrigation runoff) from Ingham to Mackay, to use residues of superseded pesticides as indicators of sediment loss to the sea, and to assemble information on water quality pressure and status in sugar catchments. Key findings, plus information on input pressures are described in this paper, and areas of concern and opportunities discussed.