The temperature dependence of mechanical strength including yield strength (YS) and ultimate tensile strength (UTS) in HPDC WZA631 alloy is investigated in a wide temperature range from room temperature (RT) to 350 °C. It is found that at 25–300 °C, YS and UTS do not drop markedly, from 173 MPa and 274 MPa at RT to 113 MPa and 170 MPa at 300 °C, respectively. While above 300 °C the flow stress falls rather rapidly, to 74 MPa for YS and to 108 MPa UTS at 350 °C. The (Al,Zn)2Y phase exhibits similar behavior between 150 °C and 350 °C, breaking up under stress and becoming the relatively stable crack source without catastrophic cracking. The LPSO phase, keeping steady and excellent critical resolved shear stress (CRSS) below 250 °C, remains unchanged with complete network structure at 150 °C and 250 °C. Therefore, the LPSO phase reinforces the alloy with slow flow stress reduction at RT-300 °C for WZA631 alloy. The tensile property deteriorates above 300 °C due to the destruction of the network structure as well as the reduction of CRSS for the prismatic slip of LPSO under tensile loading. Thus, the LPSO phase determines the mechanical strength evolution of WZA631 alloy, which is similar to the behavior of γ’ phase in the Ni-based superalloys. Besides, the relationship between strength and temperature is described by the Arrhenius equation, which may be reduced to an exponential model in the form of σ=a+bT for HPDC WZA631 alloy.