This paper proposes a new class of novel 2D layered structured materials, such as MXene (MX), for the synthesis of innovative nanofluids as coolants to evaluate the convective heat transfer performance of a double-pipe heat exchanger (DPHE). Convective heat transfer experiments were successfully conducted in lab-scale fabricated DPHE using low-concentration MXene nanofluids by varying the volume concentration of MXene nanoparticles (0.01-0.05 vol %) in different base fluids. The influence of the MXene nanofluids on various convective heat transfer parameters, such as LMTD, Nusselt number, heat transfer coefficient, and heat transfer rate without using any inserts in the DPHE was experimentally investigated. The results of the experiments revealed that the heat transfer coefficient and Nusselt number increase with increasing Reynolds number (Re) and concentration of MXene nanoparticles in the base fluids. Maximum enhancement in heat transfer coefficient (126%) was achieved for methanol-based MXene nanofluids at 0.05 vol %. Moreover, the Nusselt number exhibits a maximum enhancement of ∼50% for methanol- and water-based MXene nanofluids. In contrast, the thermal performance factor was also estimated, and it was observed that water- and methanol- based MXene nanofluids showed higher values than castor oil- and silicone oil-based MXene nanofluids. Finally, the LMTD and heat transfer coefficients were successfully validated using Aspen HYSYS 12.1 software.