Downloaded from www.ajronline.org by UCLA Digital Coll SVCS on 05/06/15 from IP address 149.142.243.67. Copyright ARRS. For personal use only; all rights reserved PictorialEssay Custom Endoprostheses for Limb Salvage: A Historical Perspectiveand ImagingEvaluation Leanne L. Seeger1, Sheila Farooki1, Lawrence Yao1'2, J. Michael Kabo3, Jeffrey J. Eckardt3 H istorically, primary bone malig nancies were treated with amputa tion. Since the mid l970s, several limb salvage reconstruction techniques have cast steel alloys. Early titanium single-piece components were machined (Fig. 2). Early knee devices were rigid hinges [1] (Fig. 2). Since the late l980s, the single-component endoprosthesis has been replaced by modular systems that use a rotating-hinge knee joint been developed, including resection arthrode sis, allografts and allograft composites, en doprostheses, and rotationplasty [1—3].These have evolved in conjunction with radiation therapy and adjuvant chemotherapy protocols that have dramatically improved patient sur vival [3, 41. Limb salvage reconstruction has three goals: The local recurrence rate should be no greater than that with amputation, the procedure should not delay the administrationof adjuvantor neo adjuvant therapy, and the reconstruction should be enduring and not associated with many local complications I [ I , 2]. Endoprosthetic limb salvage is most often undertaken for primary bone sarcomas. Less frequent indications include aggressive or multiply recurrent benign bone tumors; bone metastases; soft-tissue sarcoma involving bone; failed primary joint replacement; and recalcitrant, chronic nonunions [2—4](Fig. I). Evolution of Prosthetic Design The first endoprosthesis was implanted in I940. but this technique was not used routinely until the late I 970s. Original custom-designed single-piece Fig.1.—Indications fortotalfernoralendoprosthesisin Fig.2.—Evolution ofdistalfernoralendoprostheses.From 73-year-oldwomanwho had previouslyundergonesix procedures for arthroplasty fixation. Although en doprosthetic reconstruction is usually performed for primarybonetumors,other indicationsinclude chronic nonunionsthat are recalcitrant to conventionaltreat ment.Anteroposterior radiograph offemurshowsnon leftto right Waldius(Howmedica,Rutherford,NJ) distal fernoral replacementmadewith cast cobalt chromium alloy and rigid metal-on-metalhinge knee mechanism (thisdeviceis nolongerused);cast cobaltchromiumdis tal fernoralreplacementwith KinematicRotatingHinge Knee(Howrnedica)mechanism;Lewis ExpandableAd unionat level of midshaft. justableProsthesis distalfernoralreplacement (Wright Medical,Arlington,TN);modulardistalfemoralreplace rnentwithforgedcobaltchromiumfemoralstem,360° po rous ingrowth material,modulartitanium segment,and cobalt chromium condylar component using rotating hingekneemechanism(Howmedica). prostheses were components of ReceivedMarch17,1998;acceptedafterrevisionApril20,i998. t Department of Radiological Sciences, UCLA School of Medicine, 200 UCLA Medical Plaza, Ste. i65-57, Los Angeles, CA 90095-6952. Address correspondence to L L Seeger. 2Presentaddress:Departmentof Radiology,GeorgetownUniversityMedicalCenter,3800ReservoirRd.,NW.,2ndFloor,CCC,Washington,DC20007-2197. 3Departmentof OrthopaedicSurgery,UCLASchoolof Medicine,10833LeConteAve.,76-i16CHS,LosAngeles,CA90095-6902. AJR1998;ili:1525—1529 036i—803X/98/i7i6—1525 ©AmericanRoentgenRaySociety AJR:i71, December 1998