The contemporary study’s goal is to investigate the role of the Casson hybrid nanofluid on boundary layer flow and heat transfer over a vertical rotating cone using various base fluids. The dynamic effects of the magnetic field and heat generation/absorption are taken into account in the modeling of hybrid nanofluids. Flow-related PDEs are remodeled to ODEs through use of similarity transmutations. Furthermore, the numerical results are explained using the fourth order Runge-Kutta scheme in conjunction with the shooting technique. The solution depends on a Lorentz force, Casson parameter, heat generation/absorption and spin parameter. The dependency of the skin friction coefficient and local Nusselt number on these four parameters is numerically explored. To the best of the author’s knowledge, the presence of three types of hybrid nanoparticles (Al2O3– TiO2, TiO2–Cu and Al2O3–Cu) with Newtonian/non-Newtonian base fluids has not yet been examined. The findings of the study reveal that increasing the magnetic parameter values reduces flow velocities (tangential and swirl) and increases the tangential velocity profile of Newtonian based hybrid nanofluid. Additionally, the thermal profile and non-Newtonian based hybrid nanofluid indicate a rising trend in heat generation/absorption parameter. Furthermore, the thermal transfer rate of water-based hybrid nanofluid is increased, while the skin friction coefficient reverses.