This research intends to investigate the entropy generation on the magnetized double diffusive heat and mass transfer flow of the Casson nanofluid under the influence of an inclined magnetic field in a porous medium. Additionally, the combined impact of heat absorption, chemical reaction, Brownian diffusion, source/sink, and thermophoresis phenomena is also taken care of. The fluid flow involves convective boundary conditions for both temperature and concentration instead of a constant value at the surface. The flow-regulating system involved nonlinear PDEs that are turned into nonlinear systems of ODEs by using scaling variables and then solved this system numerically in Matlab using the bvp4c strategy, which is a collocation technique based on the Lobatto 3-stage FDM algorithm. Graphical representations illustrate the behavior of fluid velocity, entropy generation, concentration, and temperature in response to changes in flow parameters. Physical quantities like skin friction coefficient, Nusselt number, and Sherwood number have been investigated using 2D and 3D plots. Here, we concluded that the inclined magnetic field decimates the flow velocity gradually and greater values of the magnetic field lead to an increased rate of entropy generation. Furthermore, it has been noted that the temperature profile improves as the Brownian motion of particles increases, and the distribution of energy also enhances with larger values of the thermophoresis. The obtained key findings are discussed in a physical manner using graphic representation.