Objectives: Current manuscript focuses on examination of chemical reaction and heat generation impacts on 3D MHD non-Newtonian nanofluid flow with convective boundary conditions induced by permeable sheet. Additionally, Brownian motion, non-Newtonian heating and thermophoretic processes as used for this study. Methods: A computational programme, MATLAB has been used for solving the system of O.D.Es with the help of ODE45 solver. The Runge Kutta Fehlberg approach is implemented to calculate the answer to the expression for temperature, velocity, and nanoparticle concentration after the shooting process. Findings: For a variety of fluid parameters, the temperature, concentration of nanoparticles, and dimensionless velocities are shown and examined, including permeability parameter , magnetic , stretching ratio parameter , Lewis number , Brownian motion and Prandtl number , thermal Biot number , Casson fluid parameter , chemical reaction parameter . The temperature is found to increase with an enhance in the thermal Biot number and to reduce with a greater Prandtl number and stretching ratio parameter. Novelty: Although the immense significance and frequent use of nanofluids in industries and technology, no effort has been made to explore the chemical influence on MHD Casson fluid flow using a three-dimensional permeable sheet. Through similarity transformations, the Runge-Kutta Fehlberg technique converts mass, momentum, and energy conservation equations into ODEs and incorporates boundary conditions. Skin friction and the heat transmission rate past an extending surface, which have an impact on technology and production, can be predicted using the results of this study. Keywords: Chemical reaction, Buongiorno's model, Nanofluid, Biot numbers, 3D permeable sheet