The process of preliminary cleaning is a determining factor affecting the standard qualities of the seeds. The grain mass that undergoes primary processing contains significant amounts of impurities, the amount of which is strictly regulated by standards. Sieves with rectangular and round openings are the most widely used for separating maize seeds. In this study, the feasibility and efficiency of using sieves with openings in the Cassini oval shape were proposed and substantiated. Three factors subject to variation during the experiments were selected, each having a crucial influence on the process parameters: rotational speed (n, rpm), specific material feed (Q, kg), and angle of sieve inclination (α, deg.). A regression equation was developed, and the response surfaces of the dependencies of defining characteristics of the process of separation of maize seeds on sieves with openings in the Cassini oval shape were compiled and analyzed. The study showed that the rotational speed has a less significant influence on the mass of the undersize of sieved maize than the inclination angle and feeding rate. A maximum grain passage (2.9 kg) into the openings in the Cassini oval shape is obtained at a rotational speed of 290.35 min-1 and a grain feed rate of 3.06 kg min-1.