Cassava is easily cultivated and very tolerant of various soil conditions. It can be planted almost anywhere, in various types of soil, even in marginal soil where other food crops are difficult to growproperly. However, imposing higher productivity for two decades clearly reduced the quality of the soil. The aim of this study is to determine the influence of long-term cassava planting (> 20 years) on the morphology and properties of the soil, compared to mixed gardens which were rarely tilled, at 14 test sites in 10 locationsin Lampung, South Sumatra, Indonesia. Cassava cultivation over a period of more than 20 years was seen to make the soil color brighter in both layers of soil which, in turn, affected the other soil properties. Cassava cultivation for more than 20 years caused the surface horizons at half of the test sites to change from crumbs to angular blocky and granular. The physical properties of the soil that was cultivated with cassava plantations for more than 20 years did not differ significantly from those of the mixed garden soil which wasrarely tilled. However, a tendency was seen for the water available pores (WAPs) to decline. Cassava cultivation for more than 20 years greatly reduced the soil organic carbon (at a critical value of 0.01) and significantly reduced the soil pH, soil-CEC, and exchangeable bases (at a critical value of 0.1). However, the long-term cultivation of cassava did not affect the base saturation, although there was a change in the numberof exchangeable bases and the CEC of the soil.