Cask storage method is the most preferable to store spent fuel at a reactor site. Since the cask is vertically oriented within the storage facility, it is necessary to investigate the tipping-over stability of the cask subjected to seismic load. In this paper, an evaluation method of the seismic response of the cask subjected to earthquake motions is proposed. Firstly, shaking table tests were conducted using a scaled cask model on a reinforced concrete base, considering a similarity law. According to these test results, the characteristics of the tipping-over response of the cask under sinusoidal waves and natural earthquake waves were investigated, and the tipping-over stability of the cask subjected to seismic load was confirmed. Secondly, based on the assumption that the tipping-over behavior could be treated as a two-dimensional problem, the numerical simulations were carried out by means of distinct element method and compared with the experimental results. As a result, the applicability of this code for seismic response of the cask was made clear.