Case Of Uterine Adenosarcoma Research Articles

Imaging findings of uterine adenosarcoma with sarcomatous overgrowth: two case reports, emphasizing restricted diffusion on diffusion weighted imaging

BackgroundAdenosarcoma is classified as a mixed epithelial and mesenchymal tumor composed of a benign epithelial component and a malignant stromal component. The stromal component in adenosarcoma is usually low grade, and consequently the prognosis is relatively favorable. While, adenosarcoma with sarcomatous overgrowth (SO) is defined as an adenosarcoma in which the sarcomatous component constitutes more than 25% of the tumor. The stromal component is also high-grade sarcoma showing greater nuclear pleomorphism and mitotic activity, thus, it is associated with worse prognosis. MRI findings of adenosarcoma without SO have been described in previous literatures but the imaging findings in adenosarcoma with SO may be poorly defined. Therefore we present two cases of uterine adenosarcoma with SO.Case presentationPatient 1 was a 76-year-old woman referred to our hospital with complaint of abdominal distension and postmenopausal bleeding. Patient 2 was a 57-year-old woman with complaint of lower abdominal pain and abnormal uterine bleeding. On magnetic resonance imaging (MRI), T2 weighted imaging showed a large, heterogeneous high-intensity mass with hyperintense tiny cysts that expanded the uterine cavity and extended into the cervical canal for both patients. On diffusion-weighted imaging (DWI), both masses appeared as high signal intensity. Patient 2 also had a right ovarian adult granulosa cell tumor that may have contributed to development of the adenosarcoma. Patient 1 recurred with peritoneal sarcomatosis 6 months after surgery and died of the disease. Patient 2 also recurred with a left upper lung metastasis 3 months after surgery.ConclusionsDWI may depict pathological changes produced by SO of adenosarcoma as high signal intensity, even though SO does not seem to change MRI findings of adenosarcoma on other sequences. Therefore, DWI could potentially predict SO in presumptive adenosarcoma on MRI and the patient’s prognosis. It is also important for pathologists to know if SO can arise in adenosarcoma because they need to examine the tumor thoroughly to determine the percentage of SO component in the tumor volume when SO is present.

Uterine Adenosarcoma in Obese/Overweight Patients; A Report of Two Cases

Uterine adenosarcomas are an uncommon gynecological neoplasm consisting of benign epithelial and malignant mesenchymal components and usually presenting as a polypoid mass. We report herein two cases of uterine adenosarcoma. Both of the patients were obese/overweight (body mass index 32 kg/m2 and 27 kg/m2, respectively), and controlling obesity and metabolic disorders seemed to be the key to prevent their post-operative tumor recurrence. You can submit your Manuscripts at: https://symbiosisonlinepublishing.com/submitManuscript.php

A Rare Case of Mullerian Adenosarcoma of Uterus in a 14-year-old Girl

Background: Mullerian Adenosarcoma, a rare tumor, is composed of mixed mesenchymal and epithelial elements. The epithelial component is typically benign and admixed with malignant Sarcomatous Stroma. This tumor can be distinguished in approximately 8% of all uterus sarcomas and commonly originates in the endometrium as a growing polypoid mass in the uterine cavity. All age groups are affected but the average age of uterine Adenosarcoma is about 58. Case report: We aim to introduce a 14-year-old case of uterine Adenosarcoma as a rare occurrence, presenting with menometrorrhagia and formation of uterine fragile polypoid mass which extends into vagina. Total Abdominal Hysterectomy (TAH) and staging were performed. She had been clinically disease-free in a 40-month post operation follow-up. Distant metastasis is a very rare phenomenon, albeit the necessity of long-term follow-up seems necessary.Conclusion: Data accumulation of individual cases with such unusual neoplasm is essential for further experience provision.[GMJ.2014;3(4):256-9]

Uterine adenosarcoma associated to lymphovascular emboli: a case report

IntroductionUterine adenosarcoma is a rarely observed polypoid tumor with a mixed benign epithelial element and malignant stromal component. The treatment is total hysterectomy with bilateral salpingo-oophorectomy. It could be difficult to diagnose and associated to lymphovascular invasion.Case presentationA 45-year-old caucasian uniparous woman presented with uterine bleeding. She had several surgical procedures and pathology of removed recurrent polyps showed no malignancy. Finally, a total abdominal hysterectomy was performed because of atypical cells and suspected uterine adenosarcoma. The hysterectomy specimen confirmed the presence of uterine adenosarcoma associated with lymphatic and vascular tumor emboli. Surgery was completed with a second bilateral salpingo-oophorectomy and pelvic lymphadenectomy.ConclusionIn our report, we present a case of uterine adenosarcoma which was diagnosed after multiple surgical procedures and associated to lymphovascular emboli known to have a significant impact on overall survival and distant metastasis-free survival.

L’adénosarcome utérin: À propos d’un cas

Adenosarcoma of the uterus has two components: a benign epithelial proliferation and a stromal sarcoma. The purpose of this work was to report the clinical aspects and therapeutic modalities of an exceptional case of uterine adenosarcoma in a 15-year-old girl revealed by pelvic pain. Physical examination disclosed a polypoid formation protruding through the hymenal orifice. Histology of the mass confirmed the diagnosis of adenosarcoma of the uterus. The patient underwent hysterectomy and was given chemotherapy. This rare tumor (8% of uterine sarcomas) generally requires hysterectomy. Prognosis is relatively favorable.