Case Of Spindle Cell Carcinoma Research Articles

A CASE OF SPINDLE CELL CARCINOMA OF THE BREAST WITH MULTINUCLEATED GIANT CELLS

Spindle cell carcinomas of the breast are relatively rare and represent 0.12-0.15% of all breast cancers. This paper describes a case of spindle cell carcinoma of the breast with multinucleated giant cells. A 58-year-old woman had noticed a nodule in the right breast 17 years before. Recently, the nodule showed a very rapid growth and she was referred to the hospital. A malignant breast tumor, probably non-epithelial tumor, was diagnosed by aspiration biopsy cytology. Standard radical mastectomy was carried out. Histopathologically, the tumor consisted of parts of sarcomatoid and invasive intraductal carcinoma, and multinucleated giant cells were scattered on the former part. A diagnosis of spindle cell carcinoma was made. She died of pulmonary embolism due to fracture 8 months following the mastectomy. Immunohistochemically, Keratin, EMA and Vimentin were positive in both parts of sarcomatoid and intraductal carcinoma. ER was positive in only intraductal carcinoma part. It was, therefore, supposed that some intraductal carcinoma cells in this tumor were transformed into sarcomatoid cells. Multinucleated giant cell was suggested to derive from phagocyte, because CD68 recognizing macrophage was positive in multinucleated giant cells.

A Case of Spindle Cell Carcinoma of the Mandible

A Case of Spindle Cell Carcinoma of the Mandible

Head and neck spindle cell carcinoma: an evaluation of current management.

Spindle cell carcinoma is an unusual variant of squamous cell carcinoma. The histogenesis of these tumors is controversial, as is the prognosis for patients with spindle cell carcinoma of the head and neck when compared with all squamous cell carcinomas of these sites. Fifteen consecutive nondermal cases of spindle cell carcinoma of the head and neck were reviewed. Six patients had spindle cell carcinoma either in recurrent tumor or in neck metastases following treatment for squamous cell carcinoma where a spindle cell component was not initially noted. Despite aggressive management, 13 patients have died from their disease. The histogenesis and management of spindle cell carcinoma of the head and neck are discussed.

Spindle cell carcinoma of the breast

A case of spindle cell carcinoma of the breast in association with myoepithelial cell hyperplasia is presented. Immunocytochemistry demonstrated labelling of tumour cells for cytokeratin, vimentin and S-100 protein. Electronmicroscopy showed desmosomes and bundles of tonofilaments as well as fine filaments in the cytoplasm. The findings in the present case point to the metaplastic spindle cell nature of squamous carcinoma of the breast. The possible role of myoepithelial cells in the origin of the spindle cell component is discussed.

Spindle cell carcinoma of oral mucosa: Case report with immunoperoxidase and electron microscopic studies

Spindle cell carcinoma is a relatively rare tumor occurring often in the oral cavity, upper respiratory tract, and less frequently in the esophagus and skin. Recently, we encountered a case of spindle cell carcinoma of the oral mucosa. This paper reports this unusual case that presented as a diagnostic problem and illustrates the role of immunohistochemistry as an adjunct to the diagnosis of spindle cell carcinoma.

Spindle cell carcinoma of the nasopharynx

Two cases of spindle cell carcinoma of the nasophrynx are reported. The pathological features are bfiefly discussed, and the common clinical presentations, along with the current management, are reviewed.

Spindle cell carcinoma of the breast: Four cases and review of the literature

The clinical and morphologic features of four cases of spindle cell carcinoma of the breast are presented, and the comparable features of 35 previously reported cases are reviewed. All tumors contained histologically malignant squamous carcinoma that tended to blend with a spindle cell "pseudosarcomatous" stroma. Patients with this rare tumor tend to present at the same age as patients with other histologic types of breast carcinoma, but the spindle cell tumors are somewhat larger. Although the number of reported patients is too small to serve as a basis for firm conclusions, the prognosis appears similar to that for patients with conventional infiltrating duct carcinoma of the breast.

Spindle cell carcinoma of the breast: A clinocopathologic and ultrastructural study

The clinical and pathologic features in six cases of spindle cell carcinoma of the breast were reviewed. Histologically this tumor is characterized by sheets of spindle cells often containing squamous epithelial islands and numerous cystic spaces lined by epidermoid carcinoma or benign appearing squamous epithelium. Areas of transition from the squamous epithelium or epidermoid carcinoma to malignant spindle cells were seen in all cases. Features of squamous epithelial differentiation were found in the spindle areas of the one tumor examined by electron microscopy. The prognosis in this neoplasm is similar to that in the more common breast carcinomas. Spindle cell carcinoma therefore should be distinguished from broader category of “metaplastic carcinoma”, since this term includes a heterogeneous group of tumors of uncertain histogenesis and prognosis.

Spindle cell carcinoma of the oral cavity: A clinicopathologic assessment of fifty-nine cases

The clinical features, histomorphologic characteristics, therapeutic results, and follow-up data for fifty-nine cases of spindle cell carcinoma of the oral cavity were analyzed. Circumstantial evidence favors a pathogenesis from metaplastic malignant epithelial cells for the spindle cell proliferation. These neoplasms occurred most frequently on the lower lip, tongue, and alveolar ridge in either polypoid, exophytic, or endophytic configurations. A male predominance was attributed to a military and veteran bias. Mean age at occurrence was 51 years for men and 67 years for women. Symptoms were infrequently reported. Histomorphologically, fasciculated, myxomatous, and streaming patterns of the spindle cells were observed, with variable mitotic activity, pleomorphism, benign and atypical giant cells, inflammation, vascularity, and infiltration. Follow-up data on forty-five patients revealed that only fourteen were alive and well, whereas twenty-five were dead of their disease. Mean survival time for those dead of the disease was under 2 years. Five-year survival was a significant indicator of cure. No clinical or histomorphologic characteristic other than distant metastasis was found to be a reliable prognostic indicator. Wide surgical excision, alone or with radical neck dissection, was the most successful therapeutic modality. Radiation was ineffective.

A Case of Spindle Cell Carcinoma of the Urinary Bladder

A Case of Spindle Cell Carcinoma of the Urinary Bladder

Polypoid spindle-cell carcinoma (pleomorphic carcinoma): Report of a case occurring on tongue and review of the literature

A case of spindle-cell carcinoma (pleomorphic carcinoma), a rare polypoid tumor of the tongue, is reported. The characteristic clinical, gross, and microscopic features of this peculiar lesion and its common sites of location are presented. Origin and pathogenesis of the sarcoma-like elements of the lesion are discussed and the literature on the subject is reviewed. Sites of apparent transition between the spindle-cell elements of the tumor and the overlying epithelium were observed in light microscopic sections, and the electron micrographs of the spindle-cell portion of the lesion demonstrated the presence of tonofilaments and desmosomes in many tumor cells. These findings support the concept that this group of lesions are pleomorphic variants of squamous-cell carcinoma with predominantly spindle-cell pattern. Current evidence in the literature also suggests that metaplastic transformation of the tumor cells into mesenchymal elements may take place in some of these lesions, and that “metaplastic carcinoma” may probably be a more proper designation for them.

Spindle cell carcinoma: ultrastructural evidence of squamous origin and collagen production by the tumor cells.

Two cases of spindle cell carcinoma (SCC) of the esophagus and skin, respectively, were studied by transmission electron microscopy. The tumor cells were closely associated with collagen fibrils and had abundant rough endoplasmic reticulum with dilated cisternae. Except for their irregular shape and atypical nuclei they resembled actively synthesizing fibroblasts. In addition to these features, some cells contained numerous tonofibrils and occasional well-developed desmosomes. A gradual transition to typical squamous cells was noted in the skin tumor. These findings suggest that the pseudosarcomatous component of SCC originates from mesenchymal metaplasia of squamous cells and that collagen is produced by these metaplastic cells.

Spindle cell carcinoma (pseudosarcoma) of the larynx.

"Pseudosarcoma", initially considered a benign response of connective tissue to an adjacent squamous carcinoma, is now regarded as a spindle cell variant of epidermoid carcinoma. Nine cases of spindle cell carcinoma of the larynx are presented. Characteristically, the lesion appears as a large, gray, polypoid tumor. In contrast to other reports, a correlation between gross morphology and prognosis could not be made. The prognosis is more closely related to the size and location of the tumor. Biopsy specimens of the tumors in seven of the nine cases showed only the spindle cell pattern. This may be confused with granulation tissue. Spindle cell carcinoma was metastatic to the neck and lungs in three patients. Our average follow-up time was 3.8 years with two of the nine patients dying of recurrent disease. Most of our patients were successfully treated with conservation surgery.