Case Of Mucinous Cystadenoma Research Articles

A Huge Ovarian Mucinous Cystadenoma in a 14-Year-Old Premenarchal Girl: Review on Ovarian Mucinous Tumor in Premenarchal Girls

Superficial epithelial ovarian tumors are unusual in adolescent girls (when compared with adult women) and extremely rare before menarche. Mucinous cystadenoma (MCA) in children that is a rare form of epithelial tumor is a benign cystic ovarian neoplasm. To our knowledge, there are only eight cases of mucinous cystadenoma, three of borderline mucinous cystadenoma, and three of mucinous cystadenocarcinoma reported in the English-language literature. We present a 14-year-old premenarchal girl with a giant ovarian mucinous cystadenoma. This review is supported by the finding that epithelial ovarian neoplasms are extremely rare prior to puberty and that only 14 mucinous tumors have been reported prior to menarche.

Mucinous Cystadenoma Arising in an Isolated Ileal Duplication Cyst

A 64-year-old woman with a 2-year history of bilateral breast carcinoma with axillary node metastasis and chemotherapy was admitted to our hospital due to tumor attached to the ileum, discovered during the routine control examination. Computerized axial tomography showed oval cystic tumor in terminal ileum that measured 7 cm in the largest diameter and shared peritoneal coat with small intestine and was filled with dense fluid. Tumor abutted intestine but did not communicate with intestinal lumen. The surgical procedure was simple because cyst was attached to the antimesenteric side of the terminal ileum and did not communicate with the adjacent intestine. Pathohistological examination showed mucinous cystadenoma with high-grade epithelial dysplasia in the isolated ileal duplication cyst. The presence of epithelial dysplasia found in duplication cyst suggested potential to undergo malignant transformation. In conclusion, we report a unique case of mucinous cystadenoma arising in isolated ileal duplication cyst. This case report expands the potential range of clinical variability of alimentary tract duplications. Surgical removal of alimentary tract duplication in patients without symptoms is also recommended because many potential complications or even malignant transformation may result from these anomalies.

ＭＤＣＴが術前診断に有用であった腸重積合併虫垂粘液嚢胞腺腫の１例

腸重積にて発症した虫垂粘液嚢胞腺腫の1 例を経験した. 症例は46歳の女性で, 腹痛, 水様便を主訴に来院した. 腹部超音波検査, multidetector CT (以下, MDCTと略記) にて, 横行結腸に嚢胞性腫瘤を先進部とする腸重積の所見を認めた. 注腸にて整復を行ったが, 上行結腸下部に円筒状の腫瘤像が残り, 造影剤の回腸への流入は不能で, 整復は不完全であった. 当日開腹手術を行ったが, 虫垂は7.5×3.0cmと腫大し, 根部が盲腸内へ陥入していたため, 回盲部切除術を行った. 病理組織学的には単胞性の粘液嚢胞腺腫であり, 粘膜上皮および内容物質内には悪性細胞は認めなかった. 冠状断MDCTは, 腸重積の診断において有用であった.

Expression and Mutational Analysis of c-kit in Ovarian Surface Epithelial Tumors

Coexpression of Kit ligand and c-kit has been reported in some gynecologic tumors. To determine whether imatinib mesylate is useful in ovarian epithelial tumors, we performed immunohistochemical and mutational analysis. The cases consisted of 33 cases, which included 13 serous cystadenocarcinomas, 1 borderline serous tumor, 8 mucinous cystadenocarcinomas, 6 borderline mucinous tumors and 5 clear cell carcinomas. Five cases of serous cystadenoma and 5 cases of mucinous cystadenoma were also included. In the immunohistochemical study, 3 cases (3/6, 50%) of borderline mucinous cystic tumor and two cases (2/8, 25%) of mucinous cystadenocarcinoma show positive staining for KIT protein. Only one case (1/13, 7.7%) of serous cystadenocarcinoma had positive staining. On mutational analysis, no mutation was identified at exon 11. However, two cases of borderline mucinous tumors and one case of mucinous cystadenocarcinoma had mutations at exon 17. In these cases, the immunohistochemistry also shows focal positive staining at epithelial component. Although, KIT protein expression showed higher incidence in mucinous tumors than serous tumors, they lack KIT-activating mutations in exon 11. Thus, ovarian surface epithelial tumors are unlikely to respond to imatinib mesylate.

口蓋部に発生した粘液性嚢腺腫の１例

口蓋部に発生した粘液性嚢腺腫の１例

S状結腸へ癒着した虫垂粘液嚢胞腺腫の1例

S状結腸へ癒着した虫垂粘液嚢胞腺腫の1例

Two cases of mucinous cystadenoma in appendix

Two cases of mucinous cystadenoma in appendix

Expression of clusterin in human pancreatic cancer.

Clusterin, also known as apolipoprotein J, has been implicated in numerous processes, including active cell death. Clusterin is reported to be overexpressed in breast and prostate cancers. However, its expression in pancreatic cancer is yet to be reported. To examine clusterin expression and apoptosis in 52 pancreatic tissues, including specimens from 33 cases of pancreatic cancer, by immunohistochemistry. Clusterin was expressed in 49% (16) of 33 cases of pancreatic cancer, 50% (13) of 26 cases of chronic pancreatitis, and 67% (4) of 6 cases of mucinous cystadenoma. It was not expressed in normal pancreas. Clusterin mRNA was also expressed in the pancreatic cancer cell lines. Clusterin was significantly more highly expressed at stage I and II (well-differentiated and moderately differentiated cancers). Clusterin and apoptosis were localized in the same cells in pancreatic cancer. However, clusterin expression was not significantly associated with apoptosis in any pancreatic disease. Clusterin-positive patients with pancreatic cancer survived significantly longer. These results suggest that clusterin expression is induced in pancreatic cancer as well as chronic pancreatitis and that downregulation of clusterin may be involved in the progression of pancreatic cancer.

虫垂粘液嚢胞腺腫の3例

虫垂粘液嚢胞腺腫の3例

Cistoadenoma mucinoso do apêndice: relato de caso

O cistoadenoma mucinoso do apêndice ceca l, um tipo de mucocele do apêndice, é uma neoplasia benigna caracterizada pela metaplasia focal ou difusa do epitélio superficial da mucosa, associada à dilatação do apêndice e produção de muco para a luz apendicular. No presente estudo os autores relatam um caso de cistoadenoma mucinoso do apêndice observado em uma mulher de 65 anos de idade, com dor e massa palpável no quadrante inferior direito do abdome, cujo quadro teve início há 1 ano. O diagnóstico de cistoadenoma do apêndice foi suspeitado através da ultrassonografia e tomografia computadorizada do abdome, e confirmado pelo exame histopatológico. A paciente também apresentava cálculos na vesícula biliar e um cisto renal à direita. A laparotomia foi indicada sendo realizada a apendicectomia, a colecistectomia e a exérese do cisto renal. Na presente discussão esperamos contribuir para o diagnóstico precoce dessa doença e a melhor compreensão de sua classificação e patogenia.

Ｓ状結腸癌に併存した虫垂粘液嚢胞腺腫の１例

症例は56歳, 男性。便潜血陽性のため精査した結果, S状結腸癌を認めた。術前に虫垂病変は明らかでなかったが, 開腹時に7×3×3cmに棍棒状に腫大した虫垂腫瘍を認めた。盲腸への連続性はなく虫垂切除を施行し, S状結腸癌に対しては, S状結腸切除を施行した。摘出した虫垂腫瘍は, 割面が単房性で黄白色ゼリー様物質で充満していた。病理組織学的検査の結果, 虫垂粘液嚢胞腺腫と診断された. 本症例のような大腸癌に併存して認める虫垂嚢腫は, 本邦では過去に10例の報告であるにすぎずきわめて稀である。しかし欧米ではそれほど頻度が低くはなく, 今後, 虫垂粘液嚢腫の症例に対しては, 大腸癌の併存も考慮して診断, 治療にあたるべきと思われた.

A RESECTED CASE OF MUCINOUS CYSTADENOMA OF THE PANCREAS WITH ABNORMALLY ELEVATED LEVELS OF CEA AND CA19-9 IN THE CYSTIC FLUID

Recent experience with a resected case of mucinous cystadenoma of the pancreas with abnormally elevated levels of CEA and CA19-9 in the cystic fluid is presented here. A 51-year-old woman was seen at the hospital because of an abdominal tumor and was admitted for close examination and treatment. Abdominal ultrasonography, abdominal CT, endoscopic retrograde pancreatography, and abdominal angiography were done, and pancreatic mucinous cystadenoma was most probable diagnosis. Resection of the body and tail of the pancreas with splenectomy was carried out. Histopathological diagnosis was made with mucinous cystadenoma of the pancreas. CEA and CA19-9 levels in the cystic fluid were 3930.3ng/ml and 150, 000U/ml, respectively. It is generally thought that pancreatic mucinous cystadenoma has a malignant potential. Further careful observation of the clinical course is necessary in this case.

A case of mucinous cystadenoma in the tail of the pancreas accompanied with tubular adenocarcinoma in the head

A case of mucinous cystadenoma in the tail of the pancreas accompanied with tubular adenocarcinoma in the head

虫垂の粘液嚢胞腺腫（ｍｕｃｉｎｏｕｓ ｃｙｓｔａｄｅｎｏｍａ）の１例 粘液嚢胞腺癌との核ＤＮＡ ｐｌｏｉｄｙの比較

68歳の女性で右下腹部腫瘤で紹介入院腫瘤は手挙大で表面平滑,弾性硬で可動性に乏しく,USおよびCTでは石灰化を伴う嚢胞性腫瘤の形態を呈していた.切除腫瘤は13×5×3cmで,ゼリー様粘液を充満していた.組織学的に上皮細胞の異型性を有する粘液嚢胞腺腫で,pseudomyxoma様像とpsammoma bodyを伴っていた.粘液組織検査では酸性粘液で主としてsialomucinであり,核DNA ploidyはdiploidであった.対照の粘液嚢胞腺癌は腺腫と同様な粘液染色態度をしめしたが,核DNAploidyはaneuploidであった.