Cases Of Malignant Tumors Research Articles

A case of recurrent malignant phyllodes tumor undergoing nipple-sparing mastectomy with immediate breast reconstruction

BackgroundAlthough the primary treatment for malignant phyllodes tumor (PT) is complete surgical excision with either breast-conserving surgery or total mastectomy, recent technical advances have led to the adoption of nipple-sparing mastectomy (NSM) with immediate breast reconstruction (IBR).Case presentationA 28-year-old woman noticed a mass in her left breast that was rapidly increasing in size. She underwent tumor excision and a histological diagnosis of marked degenerative and necrotic induration suggested benign PT. One year later, however, she was found to have recurrent masses in the left breast on follow-up mammography and sonography. Needle biopsy was performed and the tumor was diagnosed as borderline or malignant PT. She underwent NSM and sentinel lymph-node biopsy with IBR using a tissue expander. Histological examination of the mastectomy specimen showed multiple fibroepithelial tumors with marked stromal overgrowth, focal necrosis, and hemorrhage. Stromal cells showed pleomorphism and a maximal mitotic rate of approximately 25 per 10 high-power fields. The tumor was diagnosed as malignant PT. She did not receive adjuvant chemotherapy or radiation treatment. At 3-year follow-up, the patient remains free of disease and highly satisfied with the cosmetic results.ConclusionsNSM with IBR is not a contraindication for malignant PT. It is both curative and can offer an appealing cosmetic option for localized malignant PT.

Irreversible electroporation in patients with liver tumours: treated-area patterns with contrast-enhanced ultrasound

BackgroundFamiliarity with post-IRE imaging interpretation is of considerable importance in determining ablation success and detecting recurrence. CEUS can be used to assess the tumour response and characteristics of the ablation zone. It is of clinical interest to describe the ultrasonographic findings of liver tumours after irreversible electroporation (IRE) percutaneous ablation.MethodsA prospective study of 24 cases of malignant liver tumours (22 cases of primary liver tumours and 2 cases of liver metastases) treated by IRE ablation was conducted. Two inspectors evaluated the ablation zone in a consensus reading performed immediately, 1 day, and 1 month after IRE ablation. The gold standard method, magnetic resonance imaging (MRI), was used to evaluate the effectiveness of the treatment at 1 month.ResultsImmediately after IRE ablation and up to 1 month later, the ablation zones gradually changed from hypo-echogenicity to hyper-echogenicity on conventional ultrasound and showed non-enhancement on contrast-enhanced ultrasound (CEUS). One month after IRE ablation, CEUS and MRI results were highly consistent (κ = 0.78, p < 0.05).ConclusionsWe conclude that CEUS may be an effective tool for assessing post-IRE ablation changes after 1 month. CEUS enables the depiction of tumour vascularity in real time and serves as an easy, repeatable method.

Incidence of occult uterine sarcoma and other unexpected pathologies in patients having surgery for presumed myomas: A retrospective observational study

ObjectiveTo determine the incidence of occult uterine sarcomas and other unexpected pathologies in patients undergoing hysterectomies or myomectomies with a pre-operative diagnosis of uterine leiomyomas. Study designRetrospective study. SettingTertiary hospital in Santiago, Chile. Population921 women who underwent surgery for presumed myomas.Database analysis of surgical and pathological notes, from January 2007 to December 2017 with a preoperative diagnosis of uterine leiomyoma. Main outcome measuresnumber of patients with uterine sarcoma confirmed on histology. ResultsDuring this period, a total of 921 gynecological surgeries were performed for benign uterine fibroids of which 787 were hysterectomies and 134 were myomectomies. We found four cases of malignant neoplasms (0,43 %). Two were uterine leiomyosarcoma (LMS), one mixed epithelial and mesenchymal tumor, and one case of incidental cervical cancer. This gives an LMS incidence of 1 in 460 and 1 in 921 of mixed epithelial and mesenchymal tumor. There were seven cases of unexpected benign pathology. This included six atypical myomas and one leiomyoblastoma epithelioid myoma. If we combine the malignant and benign cases, we would have an incidence of 1.2 % of unexpected pathology. ConclusionIn our series of patients undergoing myomectomies or hysterectomies for presumed myomas the incidence of LMS was 1 in 460. The incidence of any unexpected pathology including benign ones in presumed myomas was 1 in 83 (six atypical myomas, one leiomyoblastoma epithelioid myoma, two LMS, one mixed epithelial and mesenchymal tumor, one incidental cervical cancer).

Vacuum-assisted aspiration biopsy in mammology practice. Analysis of 3-year experience

Objective: to analyze the 3-year experience of vacuum-assisted aspiration biopsy under ultrasound guidance in patients with focal mammary neoplasms in categories BIRADS 2–5.Materials and methods. The totals of 121 interventions were performed in 121 patients. In 9 (7.4 %) cases there were more than 1 node in the mammary gland.Results. In 97.7 % cases the removed formations were benign. The breast cancer was detected in 5 (2.3 %) cases; there were cases of malignant tumors in each category according to the BIRADS scale. The complications were registered in 15 (12.3 %) cases and did not require surgical treatment. In 77 (63.3 %) cases the results of ultrasound monitoring were obtained in 6 months after the removal of formations, residual tissue was detected in 6 (4.9 %) patients.Conclusions. The vacuum-assisted aspiration biopsy, thus, has a high diagnostic accuracy; the number of completely removed benign formations allows us to consider the method as an alternative to sectoral resection. It is worth saying that a high percentage of complications is associated with the stage of mastering the method; all complications were resolved conservatively.

Histopathological study of ovarian tumours in a tertiary healthcare centre of southern Rajasthan

Ovarian tumors are an increasing cause for morbidity and mortality worldwide. The present study was conducted in a tertiary healthcare centre of southern Rajasthan to determine the incidence of various histological and morphological variants of ovarian tumour, their clinical presentation and age distribution. : The study was performed in two tertiary healthcare centre of southern Rajasthan and included 130 specimens of ovary received in the pathology department of two centers. The specimens were subjected to critical gross as well as histopathological study. Routine paraffin sections with H &amp; E staining were seen. The clinical as well as histological findings were compiled on proforma and then subjected to analysis. Total 130 patients were included in the study with the age range from 10 years to 90 years. Maximum patients were from age group 41-50 years (24.61%). In the present study, abdominal pain (46.1%) was the most common presenting complaint followed by mass per abdomen with irregular periods (10.7%). Majority of the ovarian tumours belonged to benign tumours (66.92%) followed by malignant tumours (28.46%). As per WHO classification, surface epithelium tumours were found to be the commonest variety (76.12%), followed by Germ cell tumour (18.46%). Three cases of metastatic tumours to ovaries were also diagnosed in the present study. Among the various known subtypes of ovarian tumours, serous cystadenoma (30.77%) was found to be the most common subtype followed by benign cystic teratoma (16.92%) and then serous cystadenocarcinoma (13.85%). Benign ovarian tumours are more common than malignant or borderline tumours. Among the histopathological subtypes of ovarian tumours, surface epithelial tumours are the commonest type followed by germ cell tumours. Differentiation between benign and malignant tumours is important to assure proper management and recovery. Similar studies with greater sample size are advisable in future.

Malignant Perivascular Epithelioid Cell Tumor Mimicking Renal Cell Carcinoma: A Diagnostic Pitfall

Abstract We describe a case of metastatic malignant renal perivascular epithelioid cell tumor in a 56-year-old male. Computed tomography initially revealed bilateral heterogeneous enhancing kidney masses, the right one significantly larger than the left. The patient underwent a right radical nephrectomy. Upon gross examination, the mass was infiltrating into the surrounding fat and had a heterogeneous cut surface with multiple hemorrhagic foci. Histologically, majority of cells were highly atypical with abundant clear cytoplasm, pleomorphic nuclei, and enlarged prominent nucleoli. Extensive lymphovascular invasion was noted. Based on morphology, the diagnosis of renal cell carcinoma, Fuhrman grade 4, with extensive rhabdoid and focal sarcomatoid features was rendered. Follow-up computed tomography demonstrated a hypodense area within the right hepatic lobe, which upon resection showed identical morphology to the renal mass, except for focal areas of prominent epithelioid cells with abundant eosinophilic cytoplasm. Immunohistochemistry of both resection specimens (kidney and liver) demonstrated positive staining for Melan-A, HMB-45, and epithelial membrane antigen, focal positive staining for TFE3, and negative staining for PAX8 and cytokeratin. The initial diagnosis of renal cell carcinoma was amended to malignant epithelioid angiomyolipoma with hepatic metastasis. The diagnosis of angiomyolipoma/perivascular epithelioid cell tumor is particularly problematic owing to the large number of potential mimics. Immunohistochemistry for myomelanocytic differentiation should be considered in the context of kidney lesions with epithelioid and spindled cell morphology.

A Rare Case of Malignant Peripheral Nerve Sheath Tumor of Larynx.

Malignant peripheral nerve sheath tumors are highly aggressive tumors and they arise either de novo or from preexisting benign schwannoma or neurofibromatosis. Malignant peripheral nerve sheath tumor of the larynx is an extremely rare neoplasm, for which accurate diagnosis is difficult and the therapy is usually delayed. Although wide surgical excision is the mainstay of treatment, radiation therapy also plays an important role in the control and treatment of locally recurrent disease and non resectable cases. Here we are reporting a case of malignant peripheral nerve sheath tumor of the larynx without definite evidences of von Recklinghausen's disease or preexisting benign peripheral nerve sheath tumor.

Primary De novo ductal adenocarcinoma of the lacrimal gland

BackgroundPrimary ductal adenocarcinoma of the lacrimal gland is a rare and aggressive malignant epithelial lacrimal gland neoplasm, morphologically and phenotypically resembles salivary duct carcinoma, and both strongly resemble infiltrating ductal carcinoma of breast. MethodRetrospective Chart review of cases of malignant lacrimal gland tumors from 2013 July to 2020 July. Authors describe the clinico radiological, morphological and immunohistochemical features of primary ductal adenocarcinoma (PDA) of lacrimal gland. Extensive review of literature of PDA of lacrimal gland and salivary gland ductal carcinoma has been performed. ResultsRetrospective chart review of the last 7 years yielded 22 malignant lacrimal gland neoplasms of which 4 cases demonstrated features of primary ductal adenocarcinoma of lacrimal gland, 2/4 cases showed an evidence of a pre existing pleomorphic adenoma and 2 were found to be de novo ductal adenocarcinomas. PDA of lacrimal gland showed expression of CK7, CK19, AR, HER2, cyclin D1 and were negative for CK5/14, CK 20, ER, PR, PSA, TTF-1, S-100 and SMA. Expression of GCDFP-15 was noted in one case. The presence of multiple events of loco-regional recurrences and/or distant metastasis necessitated a multidisciplinary approach. ConclusionsAuthors have expressed the need of clinical correlation; thorough tissue sampling and extensive immunohistochemical work up in identification of de novo PDA's and their molecular subtypes. A multi-institutional study might help in formulating the diagnostic criteria, identification of actionable targets, and thus study the role of targeted therapy in this rare and aggressive tumor which may result in better patient outcomes.

Sarcomatous tumor of the right ovary, removed by laparotomy in the gynecological department at the Mogilev obstetric institution

Unfortunately, we do not yet have accurate statistics of malignant neoplasms of the ovaries. Virkhov, for example, of the opinion that they are quite rare. In Schroeder's 600 cases of neoplasms of the ovaries, there are only 10 cases of malignant, consequently somewhat more than 1%. Wert in relation to ovarian cysts determines the frequency of dense neoplasms in 5%. Spencer Wells initially rose 1.72%, followed by even less 1.2%. Leopold), from a more distant time, there are only 8 cases of malignant neoplasms of the ovaries: 4 cases of Spencer Wlls, of which two were fatal, two cases of Spiegelberg, both were fatal, one case of Buren and one recovered a rural doctor whose patient died of a collapse shortly after the operation. Even if we assume that cases of malignant neoplasms of the ovaries are quite rare, then all the same, judging by the latest reports, it cannot be argued that this rarity would be in such a scale as the authors just cited for a longer time estimate it.

Machine and Deep Learning Based Radiomics Models for Preoperative Prediction of Benign and Malignant Sacral Tumors.

PurposeTo assess the performance of deep neural network (DNN) and machine learning based radiomics on 3D computed tomography (CT) and clinical characteristics to predict benign or malignant sacral tumors.Materials and methodsThis single-center retrospective analysis included 459 patients with pathologically proven sacral tumors. After semi-automatic segmentation, 1,316 hand-crafted radiomics features of each patient were extracted. All models were built on training set (321 patients) and tested on validation set (138 patients). A DNN model and four machine learning classifiers (logistic regression [LR], random forest [RF], support vector machine [SVM] and k-nearest neighbor [KNN]) based on CT features and clinical characteristics were built, respectively. The area under the receiver operating characteristic curve (AUC) and accuracy (ACC) were used to evaluate different models.ResultsIn total, 459 patients (255 males, 204 females; mean age of 42.1 ± 17.8 years, range 4–82 years) were enrolled in this study, including 206 cases of benign tumor and 253 cases of malignant tumor. The sex, age and tumor size had significant differences between the benign tumors and malignant tumors (χ2sex = 10.854, Zage = −6.616, Zsize = 2.843, P < 0.05). The radscore, sex, and age were important indicators for differentiating benign and malignant sacral tumors (odds ratio [OR]1 = 2.492, OR2 = 2.236, OR3 = 1.037, P < 0.01). Among the four clinical-radiomics models (RMs), clinical-LR had the best performance in the validation set (AUC = 0.84, ACC = 0.81). The clinical-DNN model also achieved a high performance (an AUC of 0.83 and an ACC of 0.76 in the validation set) in identifying benign and malignant sacral tumors.ConclusionsBoth the clinical-LR and clinical-DNN models would have a high impact on assisting radiologists in their clinical diagnosis of sacral tumors.

Clinical features of bone and soft tissue tumors of the foot and ankle: Results from a retrospective single-center case-series

BackgroundThe malignant potential of the musculoskeletal tumors of the foot and ankle has often been underestimated because of their rarity. The current study reviewed the clinical features of the tumors of the foot and ankle, and evaluated the tumor size via imaging-based analysis to distinguish between benign and malignant lesions. MethodsA retrospective review was performed using the clinical records of all patients with histologically confirmed musculoskeletal tumors of the foot and ankle, treated between 1998 and 2020 at our institution. We examined the distribution of tumors, rate of unplanned excision for primary surgery, and subsequent outcomes. In addition, the tumor size was examined via magnetic resonance imaging, and the cut-off value was determined via receiver operating characteristic (ROC) curve. ResultsA total of 103 bone and soft tissue tumors of the foot and ankle were included, of which 78 were soft tissue tumors and 25 were bone tumors. Of the 14 cases of malignant bone and soft tissue tumors, 6 (42.9%) received unplanned excision in the primary surgery, followed by amputation in 3 cases. Tumor size of malignant soft tissue tumors was significantly larger than that of benign soft tissue tumors (47.6 mm vs. 31.0 mm, respectively, P < .001). However, the difference between benign and malignant bone tumors was not statistically significant with the numbers available. ROC curve determined that the optimum diagnostic cutoff value for soft tissue tumor size was 40 mm, with a high area under the ROC curve 0.816 (95% CI: 0.711–0.921, sensitivity 91.7%, specificity 70.5%) ConclusionsWe highlighted that bone and soft tissue tumors of the foot and ankle were often misdiagnosed and initially inadequately treated. We suggest that a cutoff value of 40 mm may be a useful index for prediction of malignancy in soft tissue tumors of the foot and ankle. Level of evidenceⅢ

Computed Tomography Image Analysis and Clinical Diagnosis Value of Nasal Olfactory Neuroblastoma

This article retrospectively analyzed the data of all patients diagnosed with malignant tumors of the nasal cavity and sinuses by pathologic section in all patients (including outpatients and inpatients) in our hospital from January 2008 to December 2017 (10 years) to discuss the nasal cavity The clinical characteristics of sinus malignant tumors and the clinical characteristics (symptoms, signs, imaging examinations) of 35 cases of olfactory neuroblastoma with high incidence were analyzed, and their treatment methods and prognosis were summarized for future nasal tumors. In our department, 300 cases of malignant tumors of nasal cavity and sinuses were treated within 10 years. AGE: Eighty-six cases (28.6%) were in the age group 50-59 years old, occupying first place, and 55 cases (18.3%) were in the age group 60-69 years old, occupying second place. By comparing groups A and B with malignant tumors of the nasal cavity and sinuses, the difference in age distribution of olfactory neuroblastoma is statistically significant. Of the 35 cases of olfactory neuroblastoma, 23 cases were diagnosed with nasal tumors on admission, 12 cases were initially diagnosed with nasal polyps (including 7 cases with hemorrhagic and necrotic nasal polyps), and 20 cases underwent rapid pathologic definite diagnosis during the operation. On the basis of our analysis, the following conclusions can be drawn: Of the 300 cases of malignant tumors of the nasal cavity and paranasal sinuses, age distribution tends to be younger, the overall incidence of males is higher than that of females, but the proportion of male and female olfactory neuroblastoma is equal, and the incidence of adenoid cystic carcinoma and sarcoma. The morphology of cancer can be divided as follows: the tissue source is epithelial tissue, the cancer is harder, paler, drier, and often forms cancer nests, the parenchymal and interstitial boundaries are clear, and the fibrous tissue is hyperplastic. The incidence rate of females is higher than that of males, with the primary origin in the sinuses. Among them, the maxillary sinus is more common. Olfactory neuroblastoma, lymphoma, and sarcoma are gradually increasing in malignant tumors of the nasal cavity and sinuses.

The Prevalence of Malignant Tumors of the Eye and Adnexa (C69)

Malignant tumors of the eye and its adnexa (C69) relates to rare tumors. Until 2011, this group of tumors was not included to the official cancer report in Russia.Purpose: to investigate the incidence of malignant tumors of eye and its adnexa (C69) in the population of St. Petersburg, to consider the dynamics of a complex of analytical indicators. Standard methods of statistical analysis, state reporting materials and data from the St. Petersburg Population Cancer Register were used. Malignant tumors of the eye and its adnexa (С69) were started to be officially registered only from 2011 onwards, however not in full as only Form 7 that allows to calculate morbidity was filled in. Other information could be obtained from the databases of the Population Cancer Registers (PRR), organized in the country in the late 90’s. Each year, more than 1,000 thousand (e.g.1977–2017 year) cases of malignant tumors of eye and its adnexa (С69) are detected in the whole country. In 2011, 925 cases were diagnosed. In Russia, the crude rate of malignant tumors of the eye and its adnexa (С69) has increased from 2011 to 2017 years from 0.65/100,000 in 2011 to 0.73/100,000 in 2017, respectively, +12.3 % (both sexes), standardized, eliminating the difference in the age composition of the population, remained almost unchanged –0.54 0/0000 and 0.53 0/0000. The standardized incidence rate in men of malignant tumors of eye and its adnexa (С69) in 2017 was 0.58 0/0000, women –0.49 0/0000. The state reporting for malignant tumors of eye and its adnexa (С69) does not provide for the distribution of these patients by age, stage and other parameters. State mortality statistics do not provide for the review of the C-69 heading ICD-10. All of this led us to conduct in-depth analysis of the dynamics of morbidity and mortality of eye cancer on the basis of the PRR database of SaintPetersburg. An insignificant increase in the incidence rate of the Russian population of the eye cancer, completely associated with the aging of the population, has been established. Positive increase in the observed and relative survival of patients has been also revealed.

STATISTICAL ANALYSIS AND COMPARISON OF DATA ON PATIENTS WITH THYROID CANCER IN THE REPUBLIC OF NORTH MACEDONIA AND THE REPUBLIC OF CROATIA IN THE PERIOD FROM 2014 TO 2018

Thyroid cancers have been on the rise in recent years. One of the direct causes is the increase in ionizing radiation. The incidence is three times higher in women than in men. Most of the patients are over 50 years old. There is also a genetic predisposition. The aim of the paper is to differentiate between the results obtained for patients with thyroid cancer in Republic of North Macedonia and Republic of Croatia and to see if this type of cancer is on the rise in both countries and if the numbers are approximate in a period of 6 years from 2013 to 2018. The total number of newly diagnosed cases of malignant neoplasm of the thyroid gland in R.N. Macedonia in the period from 2014 to 2017 is 315, while in the Republic of Croatia in the same period the number of newly discovered cases is 8 times higher than in RN Macedonia and has a total of 2796 newly diagnosed patients. In RN Macedonia the incidence or the number of new patients with thyroid cancer for both sexes is increasing. The increased incidence is probably due to the increased increase in diagnosis of the disease in the early, subclinical stages (small papillary carcinoma). Survival from thyroid cancer depends on the stage at which it is detected, generally the percentage of survivors is high. Due to the possibility of recurrence, regular check-ups are required.

Identification of miRNA signatures for kidney renal clear cell carcinoma using the tensor-decomposition method

Cancer is a highly complex disease caused by multiple genetic factors. MicroRNA (miRNA) and mRNA expression profiles are useful for identifying prognostic biomarkers for cancer. Kidney renal clear cell carcinoma (KIRC), which accounts for more than 70% of all renal malignant tumour cases, was selected for our analysis. Traditional methods of identifying cancer prognostic markers may not be accurate. Tensor decomposition (TD) is a useful method uncovering the underlying low-dimensional structures in the tensor. The TD-based unsupervised feature extraction method was applied to analyse mRNA and miRNA expression profiles. Biological annotations of the prognostic miRNAs and mRNAs were examined utilizing the pathway and oncogenic signature databases DIANA-miRPath and MSigDB. TD identified the miRNA signatures and the associated genes. These genes were found to be involved in cancer-related pathways, and 23 genes were significantly correlated with the survival of KIRC patients. We demonstrated that the results are robust and not highly dependent upon the databases we selected. Compared with traditional supervised methods tested, TD achieves much better performance in selecting prognostic miRNAs and mRNAs. These results suggest that integrated analysis using the TD-based unsupervised feature extraction technique is an effective strategy for identifying prognostic signatures in cancer studies.

Endoscope-assisted transoral resection of parapharyngeal space tumors: a retrospective study

Objective:To evaluate the feasibility and safety of the endoscope-assisted transoral approach for the parapharyngeal space（PPS） tumors. Method:This retrospective study included 22 patients who were diagnosed with PPS tumors and treated with the endoscope-assisted transoral approach. Result:The postoperative pathological diagnosis included 10 cases of schwannoma, 7 cases of pleomorphic adenoma, 1 case of paraganglioma, 1 case of branchial cleft cyst, and 3 cases of malignant tumors for a diagnostic purpose. The surgical duration was between 15 minutes and 430 minutes（median duration 105 minutes）, and the intraoperative bleeding was between 10ml to 500ml（median bleeding 20 mL）. Complete resection with minor complication was performed in 21 cases, 1 case of recurrent schwannoma was done in an incomplete style because of intraoperative massive bleeding. With a 12-to-72-months follow up, there was no relapse on the 18 cases of benign tumor which were completely resected. Conclusion:Endoscope-assisted transoral resection provide cosmetic, micro-invasive and increased operative exposure to the PPS, especially for the benign tumors that medial to the carotid sheath. But is not recommend for relapsed cases and lesions that encompassing or lying posterolateral to the carotid sheath.

Epidemiology of brain tumors in the United Arab Emirates: a National Registry Cross-sectional Study

BackgroundCancer is the third leading cause of death in the United Arab Emirates (UAE); brain cancer ranks 10th among the cancers, with 2.9% of the primary cancers originating from the nervous system. The epidemiology of brain cancers has not been explored. The unique population dynamics of UAE make it a fertile ground for analyzing the epidemiology of brain cancer. In this study, we aim to look at the frequency patterns and distribution of malignant primary brain tumors in the UAE.MethodsA cross sectional study was carried out using data obtained from the Tawam Hospital Cancer Registry for the years 1984–2017. The sample size included 756 diagnosed cases of malignant primary brain tumors in the UAE. Using SPSS and Excel software, frequencies, mean ages, histological type frequencies, average annual crude incidence rates and average annual age adjusted incidence rates were analyzed.ResultsThe expatriate population had higher percentage of brain tumors (72%) than the locals. The mean age at diagnosis was 33.48 years (± 21.14 years) with a male to female ratio of 1.69. Diffuse astrocytic and oligodendroglial tumors were the most commonly diagnosed tumors overall. Older adults had more cases of lymphoma while embryonal and ependymal tumors were most commonly seen in younger age groups. The overall average annual crude incidence rate for 2013–2016 for all primary brain tumors was 0.56 per 100,000 population.ConclusionThis is the first cancer registry study in the UAE that describes histological types of primary brain tumors based on the WHO 2016 classification of brain tumors and highlights their incidence rates. Through this study, several patterns of incidence trends for brain tumors in the UAE, according to histological types, sex and age groups have been recognized. Comparative studies would help identify the influence of potential changes in lifestyle, environmental or occupational risk factors on primary brain tumors.

Malignant tumours of the parotid gland: management of the neck (including the clinically negative neck) and a literature review

Major salivary gland malignancies are rare, constituting 1%-3% of head-neck tumours. The surgical management of the clinically negative neck (cN0) does not have a univocal consensus yet. We have carried out a retrospective study on 119 cases of malignant parotid tumours that were surgically treated between January 1999 and January 2014. Our aim was to analyse preoperative findings (cytotype, cTNM) and to correlate these with postoperative results (grading, histotype, occult neck metastasis) in patients with parotid tumours to obtain an appropriate indication for neck management. In cN0 patients with a T1, T2 low-grade cancer a wait-and-see approach is preferred. Instead, in cNO patients with high-grade or low-grade T3, T4 tumours an elective neck dissection (END) is always planned. Levels II, III and IV, at least, must be dissected. The decision to dissect level V or I depends on the location of the primary tumour. In the cN0 group 19 of 58 (32.7%) patients who underwent an END had occult metastases. In clinically positive neck (cN+) patients a Modified Radical Neck Dissection (MRND), at least, must be performed. The criteria to add adjuvant radiotherapy (PORT) include deep lobe parotid tumours, advanced lesions (T3-T4), microscopic (R2) or macroscopic (R1) residual disease after surgery, high grade tumours, perineural diffusion, lymph node metastasis, capsular rupture, and local recurrence after previous surgery. Kaplan-Meier analyses have shown a reduction in the overall survival (OS) from 100% to 91% and in disease-free survival (DFS) from 100% to 95.5% for the NO-PORT and PORT group, respectively. In our study, the cN0 pN+ patients had a higher degree of DFS compared to the cN+.

Trends in cancer incidence and survival in the Augsburg study region—results from the Augsburg cancer registry

ObjectivesKnowledge about time trends of cancer incidence and cancer survival in a defined region is an essential prerequisite for the planning of regional healthcare infrastructure. The aim of the study...

Creation of an architectural space in oncological rehabilitation centers

In the modern world, individual space features in architectural design are becoming a priority. A crucial task is the creation of clinical rehabilitation centers (CRCR), capable of providing high value care to oncological diseased (OD) children in remission [1]. According to the Ministry of Health of the Russian Federation for the last period, the disease incidence of children and adolescents with oncology diseases is 15 cases per 100,000 children. Over the past decade, the number of OD children, registered annually, has increased by 12 %. According to the State Statistics Committee data, published in 2019 in the Russian Federation, about 4,000 new cases of malignant neoplasms in children are registered. The study found the emergence of qualitatively new structural units in medical institutions, the activities of which are aimed at the partial rehabilitation of oncological diseased children [2, 3]. The absence of a complex approach in the rehabilitation of oncological diseased children is also noted.