Cases Of Malignant Lymphoma Research Articles

A Case of Malignant Lymphoma with Subglottic Stenosis

A Case of Malignant Lymphoma with Subglottic Stenosis

Spectrum of Malignant Lymphoma in a Tertiary Care Hospital of North Eastern India

Background: The term malignant Lymphomas embrace a variable group of Proliferative diseases that originate in the Lymph node or extra nodal Lymphatic Tissue. It constitutes 3.69% of all Malignancies World Wide. The incidence of Lymphoma exhibits a marked Geographic variation in the World.Methods: The study included58 patients who were histologically diagnosed as Malignant lymphomas in our hospital, the paraffin embedded blocks of these cases were evaluated by a panel of immunohistochemistry markers by taking proper controls and using the standard protocol. Statistical analysis were performed by SPSS software.Results: Out of the 58 cases of Malignant Lymphoma 47 were diagnosed as Non Hodgkins Lymphoma and 11 cases (19%) as Hodgkins Lymphoma. Of these 58 cases of Malignant Lymphoma, adults were 51 and paediatric cases were 7, male female ratio was 2.6:1 and Non Hodgkins Lymphoma was Commoner. B cell Lymphomas were the predominant type accounts for 74.5% of all Non Hodgkins Lymphoma cases of these B cell Lymphomas Diffuse large B cell Lymphoma was the Predominant type.Among the T cell Lymphomas Anaplastic large cell Lymphoma was the commonest subtype. Nodular Sclerosis Cases were seen most commonly in the Hodgkins Category. Extra nodal Lymphomas were also seen in 35.6% cases with Tonsil being the commonest site.Conclusion: Non Hodgkins Lymphoma was significantly more common in this region and diffuse large B cell Lymphoma was the predominant type. A combination of Histopathology and a Meticulous Immunohistochemistry helps in properly solving the diagnostic challenges.DOI:10.21276/APALM.1631

A Case of Malignant Lymphoma of the Thyroid Presenting with Dyspnea Caused by Swelling of the Hypopharynx

A Case of Malignant Lymphoma of the Thyroid Presenting with Dyspnea Caused by Swelling of the Hypopharynx

Two Cases of Malignant Lymphoma Associated with Methotrexate Diagnosed by Transbronchial Biopsy

Two Cases of Malignant Lymphoma Associated with Methotrexate Diagnosed by Transbronchial Biopsy

A Case of Malignant Lymphoma of the Ileum Resected with Laparoscopy-assisted Surgery: A Strategy for Intussusception of Small Intestine

A Case of Malignant Lymphoma of the Ileum Resected with Laparoscopy-assisted Surgery: A Strategy for Intussusception of Small Intestine

Clinical utility of 18 F-fluorodeoxyglucose/positron emission tomography in diagnosis of immunoglobulin G4-related sclerosing sialadenitis.

The aim of this study was to evaluate the utility of 18 F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) for accurately diagnosing immunoglobulin G4-related sclerosing sialadenitis (IgG4-SS). Retrospective cohort study. We reviewed the records of 64 patients with IgG4-SS (35 male and 29 female patients) and 10 patients with clinically suspected IgG4-SS. Pathological diagnoses of patients clinically suspected with IgG4-SS included four cases of malignant lymphoma, one case of multicentric Castleman disease, one case of Sjögren's syndrome, and four cases of sialadenitis. All patients underwent submandibular gland (SMG) biopsies and baseline FDG-PET/CT evaluation. Clinical, serological, pathological, and PET/CT findings were analyzed. We also investigated maximum standardized uptake values (SUVmax) in the salivary glands of 15 patients with malignant disease of the salivary glands during the same period. Increased FDG uptake in the SMG and parotid gland was found in 63 (98%) and 23 (35%) patients with IgG4-SS, respectively. FDG uptake of the bilateral SMG and unilateral SMG was recorded in 57 patients (89%) and six patients (9%), respectively. Mean SUVmax in patients with malignant disease of the salivary glands was significantly higher than that in patients with IgG4-SS (P = .035). We defined a positive test for IgG4-SS diagnosis as high SMG FDG uptake and serum IgG4 level ≥135 mg/dL, resulting in a sensitivity, specificity, and accuracy of 96.9%, 90.0%, and 86.4%, respectively. FDG-PET/CT findings in combination with serological and clinical findings may have the capacity to diagnose IgG4-SS and lead to less-invasive biopsy procedures. 4. Laryngoscope, 128:1120-1125, 2018.

Coffee and Green Tea Consumption and Subsequent Risk of Malignant Lymphoma and Multiple Myeloma in Japan: The Japan Public Health Center-based Prospective Study.

Background: The aim of this study was to investigate the association of coffee and green tea consumption and the risk of malignant lymphoma and multiple myeloma in a large-scale population-based cohort study in Japan.Methods: In this analysis, a total of 95,807 Japanese subjects (45,937 men and 49,870 women; ages 40-69 years at baseline) of the Japan Public Health Center-based Prospective Study who completed a questionnaire about their coffee and green tea consumption were followed up until December 31, 2012, for an average of 18 years. HRs and 95% confidence intervals were estimated using a Cox regression model adjusted for potential confounders as a measure of association between the risk of malignant lymphoma and multiple myeloma associated with coffee and green tea consumption at baseline.Results: During the follow-up period, a total of 411 malignant lymphoma cases and 138 multiple myeloma cases were identified. Overall, our findings showed no significant association between coffee or green tea consumption and the risk of malignant lymphoma or multiple myeloma for both sexes.Conclusions: In this study, we observed no significant association between coffee or green tea consumption and the risk of malignant lymphoma or multiple myeloma.Impact: Our results do not support an association between coffee or green tea consumption and the risk of malignant lymphoma or multiple myeloma. Cancer Epidemiol Biomarkers Prev; 26(8); 1352-6. ©2017 AACR.

Cytogenetics with flow cytometry in lymph node/extranodal tissue biopsies is sensitive to assist the early diagnosis of suspected lymphomas.

Few studies have examined the value of cytogenetic studies with flow cytometry (FC) in lymph node/extranodal tissue biopsies with suspected lymphoma. To evaluate this, G-banded karyotyping and/or fluorescence in situ hybridization (FISH) with FC immunophenotyping were performed on 185 lymph node or extranodal tissue biopsy specimens with suspected lymphoma. Complete cytogenetic analysis of lymph node/extranodal tissue was successful in 174 cases (94.1%) and 57.5% demonstrated chromosomal abnormalities. In 116 malignant lymphoma cases, 83.8% showed abnormalities. In 74 B cell lymphomas (B-NHL), abnormalities were more frequent in lymph node/extranodal tissues than in bone marrow by conventional cytogenetics (CC, 97.2 vs 26.1%), FISH (70.6 vs 17.6%), and FC (98.6 vs 28.4%). Three B-NHL diagnoses were confirmed by re-biopsy of lymph nodes due to the presence of abnormalities in the first biopsy, but no evidence of malignancy in pathological, FC, or IgH/TCR gene rearrangement analyses. In 29 T cell lymphomas (T-NHL), abnormalities were more frequent in lymph nodes than in bone marrow by CC (67.9 vs 21.4%) and FC (75.9 vs 27.6%) analyses. As expected, in 13 Hodgkin lymphoma cases, abnormalities were more frequent in lymph nodes than bone marrow by CC (41.7 vs 16.7%) and FC (30.8 vs 7.7%) analyses. In 56 reactive lymphoid hyperplasias (RLH), 7.1% had conventional clonal cytogenetic abnormalities. Two of these patients died of disease progression and two had their pathological diagnosis revised after the second review. These findings indicate that cytogenetic analysis combined with FC in lymph node/extranodal tissue biopsies can provide critical information in the auxiliary diagnosis of lymphoma.

Development of malignant lymphoma after metal-on-metal hip replacement: a case report and review of the literature

A number of previous studies have reported a potential risk of malignancy, particularly hematological malignancy, developing in patients receiving a metal-on-metal (MoM) hip replacement. We report a case of malignant lymphoma that arose in a patient who had an MoM hip arthroplasty complicated by development of a pseudotumour. The tumour was a B cell follicular lymphoma that involved lymph nodes and bone. Metal ions are known to have a genotoxic effect on lymphoid cells. Although epidemiological studies have not established that there is an increased risk of lymphoma associated with MoM implants, only a relatively short time period has elapsed since re-introduction of this type of implant and long-term follow-up of patients with MoM implants is indicated.

A retrospective analysis of clinical characteristics, diagnosis in patients with unilateral sinus disease

Objective:The aim of this study is to investigate the clinical features in patients with unilateral sinus disease.Method:A retrospective review of 2 480 patients who had undergone sinus surgery was performed. The clinical data were gathered and analyzed to investigate the features of the unilateral sinus disease. Descriptive and inferential statistics were computed.Result:1 350 patients (54.4%) who had bilateral sinus disease were all diagnosed as chronic rhinosinusitis pathologically confirmed after surgery. Unilateral sinus disease was identified in 1 130 patients (45.6%) and the disease entities were categorized as chronic rhinosinusitis (589 patients, 52.1%), fungal rhinosinusitis (312 patients, 27.6%), inverted papilloma (95 patients, 8.4%), sinus cyst (78 patients, 6.9%), malignant tumor (34 patients, 3%), osteoma including osteodysplasia fibrosa (11 patients, 1%) and others (11 patients, 1%) . Among the patients of malignant tumor, there were 13 cases of squamous cell carcinoma, 6 cases of malignant lymphoma, 4 cases of sarcoma, 4 cases of melanoma, 3 cases of adenocystic carcinoma, 1 case of verrucous carcinoma, 1 case of metastases from liver, 1 case of plasmacytoma,and 1 case of hemangiopericytoma. The number of fungal rhinosinusitis patient increased year by year. The common major presenting symptom for fungal rhinosinusitis was headache (46.8%) and bloody discharge (31.1%). Male accounted for a large part of both inverted papilloma and malignant tumor patients, both of which CT findings that correlated with the presence was the absorption and destruction of the sinus wall. Thirty-one cases (32.6%) of inverted papilloma patients recurred. Bloody discharge (58.8%) was major symptom of the malignant tumor.Conclusion:There were almost a half of unilateral sinus diseases that were not common chronic rhinosinusitis, in which the incidence of fungal rhinosinusitis, inverted papilloma, squamous cell carcinoma and other kinds of benign and malignant tumor was high. A careful history taking and endoscopic examination play a key role as well as imaging examination in identifying unilateral sinus disease, which is important for reaching a correct diagnosis and treatment.

三叉神経の単神経障害を初発症状とした悪性リンパ腫例

悪性リンパ腫は全身疾患であり様々な初発症状を生じるが，脳神経の単神経障害を初発症状とすることは稀である。しかし蝶形骨洞や翼口蓋窩周囲に病変が存在する場合には動眼神経や三叉神経障害を呈することがあり，鑑別疾患の一つとして留意しておく必要がある。今回，頭蓋内に明らかな病変がないにもかかわらず三叉神経の単神経障害を初発症状とした非常に稀な悪性リンパ腫症例を経験したので報告する。

A Case of Malignant Lymphoma Discovered During Treatment of Superior Mesenteric Vein Thrombosis

A Case of Malignant Lymphoma Discovered During Treatment of Superior Mesenteric Vein Thrombosis

EUS-FNAにより診断し得た腹腔内悪性リンパ腫の1例

EUS-FNAにより診断し得た腹腔内悪性リンパ腫の1例

HDliveFlow with HDlive Silhouette Mode for Diagnosis of Malignant Tumors of Uterine Cervix

ABSTRACT Objective To present our experience of using HDliveFlow with the HDlive silhouette mode to assess malignant tumors of the uterine cervix. Materials and methods Five women with malignant tumors of the uterine cervix (one case each of malignant lymphoma, cervical cancer stage IIA, and three of cervical cancer stage IVb) were studied using HDliveFlow with the HDlive silhouette mode. Results In a case of malignant lymphoma of the cervix, HDliveFlow with the HDlive silhouette mode demonstrated a markedly hyper-vascularized uterus with numerous vessels radiating out from the periphery of the uterus to its center (radialvascular pattern). In four cases of advanced cervical cancer (one case each of stage IIA, and three of stage IVb), HDliveFlow with the HDlive silhouette mode revealed a central hyper-vascular tumor within the peripheral vascular-ring appearance of the cervix, and clearly demonstrated the configuration of the tumor. Conclusion HDliveFlow with the HDlive silhouette mode may provide useful information on the diagnosis of malignant tumors of the uterine cervix. How to cite this article Tanaka T, AboEllail MAM, Ishimura M, Yamamoto K, Ishibashi M, Mori N, Kanenishi K, Hata T. HDliveFlow with HDlive Silhouette Mode for Diagnosis of Malignant Tumors of Uterine Cervix. Donald School J Ultrasound Obstet Gynecol 2016;10(4):409-412.

Dumbbell Scoring System: A New Method for the Differential Diagnosis of Malignant and Benign Spinal Dumbbell Tumors.

Retrospective diagnostic analysis. The aim of the study was to establish a new scoring system, the dumbbell scoring system (DSS), for preoperative evaluation of the malignant potential of spinal dumbbell tumors (SDTs). Among SDTs, benign tumors such as schwannomas occur frequently, whereas malignant SDTs, including malignant peripheral nerve sheath tumors, are uncommon. No scoring system has been developed to preoperatively diagnose the malignant potential of SDTs. We retrospectively reviewed the records of 59 consecutive patients with SDTs. The following imaging features were recorded: tumor size, tumor shape, tumor boundary, pattern of enhancement of intratumoral lesions (homogeneous or heterogeneous), cyst formation in the tumors on magnetic resonance imaging, and enlargement of neural foramina and scalloping or osteolytic destruction of surrounding bones on computed tomography. The prevalence of characteristic imaging features in malignant and benign SDTs were evaluated, and appropriate cut-off points for the DSS score were obtained using receiver operating characteristics. Twenty cases were confirmed to be malignant tumors. Pathological diagnoses of the malignant SDTs were as follows: 11 cases of malignant peripheral nerve sheath tumor; 3 cases of malignant lymphoma; and 1 case each of extraskeletal Ewing sarcoma, hemangiopericytoma, hemangioendothelioma, malignant myoepithelioma, neuroblastoma, and plasmacytoma. The DSS was based on four characteristic imaging features confirmed as significant predictors of malignant SDTs, namely, maximal diameter greater than 5 cm, irregularly lobulated tumor, tumor boundary indistinguishable from surrounding tissues, and osteolytic bone destruction. Malignant SDTs showed a higher DSS score (median 5.5 points) than did benign SDTs (median 0 point). The optimum cut-off value for the DSS score was 3 points, and the sensitivity and specificity for the diagnosis of malignant SDTs were 90% and 84.6%, respectively. This scoring system may be helpful for preoperative decision making. If the DSS score is equal to or higher than 3, biopsies was recommended to confirm the histological diagnosis. 4.

Clinicopathological Study of Malignant Lymphomas

Background: Lymphoma is the most common form of haematological malignancy in the developed and developing countries. There is a remarkable increase in the incidence of lymphomas worldwide. Lymphomas are divided as Hodgkin lymphoma (HL) andnon-Hodgkin lymphoma (NHL). Aims and objectives of the study:To determine the incidence and to study the clinical and pathological patterns of lymphoma (Hodgkin and non-Hodgkin lymphoma). Materials and methods: A total of 50 cases were studied from June 2013 to June 2015 prospectively at a tertiary health care centre, Mangalore. Patient’s data were retrieved from hospital records. The histopathological examination of lymph node and/or other involved organ was done and diagnosis was made. Immunohistochemical analysis was done for all the cases. Statistical analysis: Chi-square test was used to find association between the different subtypes and SPSS version 16 was used for statistical analysis. Results: The study group consisted of 50 cases of malignant lymphomas. Among all 50 cases of lymphomas, NHL comprised of 84%, while HL comprised of 16%. The age distribution of the patients ranged from 9 to 76 years with a mean age of 51.3 years. Both NHL and HL had a male preponderance with 66.7% and 62.5% respectively. The most common symptoms encountered in the study was lymph node enlargement in 64%. Both nodal and extranodal lymphomas accounted for 50% of cases each. Among NHL, 59.5% had extranodal involvement and 40.5% had nodal involvement. All the cases of HL were of nodal type. Most common site of extranodal lymphoma was gastrointestinal tract (24%). The most common group of lymph nodes involved was cervical group followed by axillary group in both HL and NHL. In NHL, Bcell type was 71.4% and T-cell type was 28.6%. Among B-cell lymphoma, diffuse large B cell lymphoma (DLBCL) was the most common histological subtype (66.7%). Among T-cell, extranodal NK/T cell lymphoma was most common (25.1%) type. MCCHL (50%) was the most common in HL. Conclusion: Lymphomas are potentially curable malignancies with the help of proper subtyping based on

悪性リンパ腫肝浸潤により急性肝障害を呈した2例

悪性リンパ腫肝浸潤により急性肝障害を呈した2例

Characterization of Endoscopic Findings of Small Bowel Tumors and Clinical Usefulness of Double-Balloon Endoscopy

Introduction: While 35 cases of small bowel tumor have been diagnosed since introduction of double balloon endoscopy (DBE) in our hospital, most cases of the disease were diagnosed at advanced stage with remarkable ulcerous lesion. To characterize endoscopic findings, we retrospectively analyzed endoscopic images of small bowel tumor cases diagnosed in our hospital. Methods: Based on the medical records, we retrospectively analyzed endoscopic images and patients' characteristics of 35 small bowel tumor cases diagnosed at Kyorin University hospital from 2005 to 2014. Results: In 35 cases, male-to-female ratio was 17:18 and mean age was 65.4 years. The reason for taking DBE was 21 of gastrointestinal bleeding of obscure origin (OGIB), 5 of ileus, 5 of tumorous lesions detected by other modalities, 2 of vomiting, and 2 of others. In the cases of OGIB, 15 cases were malignant tumors, and all of them were advanced stage. There was none of malignant tumor at earlier stage. Final diagnosis of 25 small bowel tumor cases were malignant tumors including 9 of GIST, 7 of adenocarcinoma, 4 of malignant lymphoma, 3 of metastatic small intestinal cancer, 2 of neuroendocrine tumor (NET). Other 10 cases were benign tumors. In the endoscopic images, submucosal tumor-like ridges with redness were observed in all 9 GIST cases including 6 cases with ulcer. All of the 7 adenocarcinoma cases were found as protruded lesions with ulcers. Irregular protruded lesions with ulcers were observed in all 4 malignant lymphoma cases. In a NET case, a protruded lesion with narrow-shaped ulcer was observed. As described above, ulcerous lesions with deep and wide range were concurrently observed in 22 of 35 small-bowel tumor cases, particularly, in malignant lymphoma, adenoma, and metastatic small-bowel tumor. About safety of DBE, perforation as complication was occurred only in a case of metastatic small bowel tumor. Conclusion: Although the majority of reason for DBE was OGIB, many cases were found at advanced stage in malignant cases. These lesions were often appeared as tumor with a wide range of ulcerous lesions. DBE is useful for pathological diagnosis of small bowel tumors, but further improvement is necessary for diagnosis of malignant tumor at earlier stage.

Lymphoma of Ovary: A Primary Extra-nodal Manifestation

Involvement of the ovary by malignant lymphoma is a well-known manifestation of disseminated nodal disease. But, lymphoma as primary manifestation is extremely rare. Here, we report a case of malignant lymphoma which presented as ovarian cancer and managed with surgery and subsequent chemotherapy. A lady of thirty two years presented with features of malignant ovarian tumor. The diagnosis of malignant ovarian lymphoma was made after surgery and histological and immunohistochemical study of the excised tumor. The tumor was classified as diffuse large B-cell lymphoma. The patient was put on chemotherapy and she is on follow-up in disease free-state for last two years.

Diffuse large B cell lymphoma of the cranial vault: two case reports

Malignant lymphoma of the cranial vault is a rare entity and the tumor growth patterns are not well understood. Here we report two cases of malignant lymphoma involving the scalp and epidural space with slight changes in the intervening skull. A 63-year-old woman presented with a scalp mass in her right frontal area. Computed tomography (CT) and magnetic resonance (MR) imaging demonstrated mass lesions in the scalp and epidural space with slight osteolytic changes in the intervening skull. She underwent resection of the lesions. A 53-year-old man presented with a mass in his right frontal area. CT and MR imaging showed mass lesions in the scalp and epidural space without changes in the skull. He underwent resection of the lesions. The histopathological diagnosis was diffuse large B cell lymphoma in both cases. Microscopic examination of the intervening skull found that the bone marrow was diffusely replaced by lymphoma cells, and lymphoma cells extended to the extra- or intra-cranial space along the emissary veins without destruction of the cortical or trabecular bone. These histopathological findings explain the radiological findings and provide the clues to elucidate the mechanism of extension of cranial vault lymphoma.