Case Of Extramedullary Plasmacytoma Research Articles

陰嚢穿刺細胞診にて診断し得たこう丸形質細胞腫の１例

陰嚢穿刺細胞診にて診断し得たこう丸形質細胞腫の１例

Fine-needle aspiration of plasma cell disorders: special emphasis on plasma cell subtype.

Fine-needle aspiration cytology and clinical presentations of 16 cases of plasma cell dyscrasias (PCD) have been studied in a period of 6 yr. There were seven cases of solitary plasmacytomas of bones, two cases of extramedullary plasmacytomas, and seven cases of multiple myelomas. Differential counts of mature and immature plasma cells along with presence of cell clumps, mitosis, and bi/multinucleations were studied. The cytological findings revealed no correlation with the different subtypes of PCDs; however, it was helpful in the differential diagnosis. Bone marrowing findings, immunological parameters, available histopathology, and X-ray appearances were analysed. Clinical diagnosis of PCDs were made in only three cases. Thus fine-needle aspiration biopsy was considered as an important diagnostic modality in tissue diagnosis of plasma cell tumors, particularly in solitary plasmacytoma of bone and extramedullary plasmacytoma.

Extramedullary nasal plasmacytoma

An extremely rare case of Extramedullary Plasmacytoma of nose is reported. The pathogenesis and management discussed.

Unusual Case of Plasma Cell Tumor with Monoclonal Gammopathy of the Sino-Nasal Cavity and Clavicular Bone

A rare case of extramedullary plasmacytoma in the sino-nasal cavity is presented. During a prolonged clinical course, the tumor has recurred several times after irradiation, chemotherapy and surgery, and presented in the clavicular bone as well. Immunohistochemical staining of each tumor showed IgA kappa phenotype, and immunoelectrophoresis of the serum showed overproduction of IgA with kappa light chains. Although an elevation of serum IgA persists, the patient has remained well without evidence of overt multiple myeloma.

上咽頭原発の髄外性形質細胞腫の一症例

上咽頭原発の髄外性形質細胞腫の一症例

Solitary plasmacytomas of bone and extramedullary plasmacytomas. A clinicopathologic and immunohistochemical study.

Twenty-two patients with solitary plasmacytoma of bone (SPB) and 13 with extramedullary plasmacytomas (EMP) were studied. The average follow-up period for SPB was 90 months and 86 months for EMP. Thirty-six percent of patients with SPB developed multiple myeloma (MM) in an average of 39 months, and 23% of patients with EMP developed MM in an average of 23 months. No significant differences in survival, incidence of MM, or interval to the development of MM were found between the two groups. The 11 cases of EMP with evaluable tissue for immunohistochemical study were either monotypic kappa or lambda, as were 9 of 10 SPB. Presence of monoclonality did not predict the development of MM. The histologic parameters of nuclear immaturity and presence of prominent nucleoli seem to be the best indicators of which patients will develop MM. Solitary plasmacytoma of bone and EMP appear to be more closely related than has been previously recognized.

Extramedullary Plasmacytoma of the Mediastinum

A case of extramedullary plasmacytoma originating from the upper mediastinum is described. Its pathologic, cytologic and immunohistopathologic findings were distinctive. The neoplastic cells had dense bodies in the cytoplasm. Neither M-protein in the serum nor Bence Jones protein in the urine was detected. However, cellular IgG, having a lambda-type light chain was shown, by immunohistochemical staining following trypsin digestion, to be present in the tissue sections.

Extramedullary Plasmacytoma of the Oropharynx Producing κ-Type Bence-Jones Protein

A case of extramedullary plasmacytoma in the oropharynx of a 41 year-old woman is reported. Histologically, the tumor was plasmacytoma consisting mainly of matured plasma cells and showing a deposit of amyloid in the interstitial structure. Immunoelectrophoretic studies of the concentrated urine specimen revealed a kappa-type Bence-Jones protein even though there was no increase in blood M-protein. Lineac electron radiation of 5,100 rad was given over a period of eight weeks but no effect was noted. After the tumor was surgically removed, follow up of the patient was made for 2 years without evidence of recurrence or metastasis.

Plasmacytoma of Lymph Nodes

MULTIPLE MYELOMA is a neoplastic disease of unknown origin, usually associated with the proliferation of abnormal plasma cells. It is characterized by multiple involvement of the skeletal system. Tissue other than the skeletal system may also be involved in multiple myeloma. Extraosseous involvement of lymph nodes, spleen, kidneys, tonsils, and other tissue has been described. Extraosseous myelomatous involvement may take the form of extramedullary plasma cells histologically indistinguishable from myeloma cells of the bone marrow. These occur most often in the upper respiratory tract or oral cavity. In a review of 127 published cases of extramedullary plasmacytoma, Hellwig1found that 63 originated in the air passages. Recently Dolin and Dewar2reviewed 161 reported cases. Excluding lesions of conjunctiva, 78% occurred in the upper air passages and oral cavity. Occasionally myeloma may be found in only a single focus such as a rib, mandible, spine, or lymph node. These