Cases Of Diffuse Pulmonary Ossification Research Articles

A Case of Diffuse Pulmonary Ossification Diagnosed by Bronchoscopy

A Case of Diffuse Pulmonary Ossification Diagnosed by Bronchoscopy

DIFFUSE PULMONARY OSSIFICATION

Diffuse pulmonary ossification is a rare form of interstitial lung disease. Specific symptoms are often lacking. The present article describes a case of diffuse pulmonary ossification in an elderly person.

Diffuse Pulmonary Ossification Developing in Patients with End-stage Renal Disease

Diffuse pulmonary ossification (DPO) is a rare condition characterized by chronic metaplastic ossification of the lung parenchyma. DPO is associated with various underlying pulmonary, cardiac, and systemic diseases. However, to our knowledge, DPO has rarely been described in patients with end-stage renal disease undergoing hemodialysis. We describe two cases of DPO diagnosed in long-term hemodialysis patients. Awareness of this rare disorder is required for a better differential diagnosis of cases presenting with bilateral diffuse micronodular lesions, including calcific opacities. (Korean J Med 2016;90:346-350)

Diffuse Pulmonary Ossification as a Rare Cause of Interstitial Lung Disease

Diffuse pulmonary ossification (DPO) is a rare form of interstitial lung disease. The present article describes a case of DPO in an elderly man who presented with progressive dyspnea on exertion and an isolated reduction in diffusing capacity for carbon monoxide. DPO may occur as sequelae of mitral stenosis, left heart failure, idiopathic pulmonary fibrosis, recurrent aspiration pneumonia, solid organ transplant, adult respiratory distress syndrome or may arise idiopathically. In the absence of other findings of interstitial lung disease, a lung biopsy is unlikely to be helpful in the management of these patients.

DIFFUSE ALVEOLAR HEMORRHAGE ASSOCIATED WITH DENDRIFORM PULMONARY OSSIFICATION

INTRODUCTION: Diffuse pulmonary ossification is a rare entity that presents with bone formation within the lung parenchyma. Patients are generally asymptomatic and diagnosis is usually made at autopsy, but patients can rarely present with dyspnea, cough, and hemoptysis. Although a specific etiology has not been established, it has been associated with acute and chronic lung disease, heart disease and other systemic disorders. Diffuse alveolar hemorrhage (DAH) can complicate a large number of clinical conditions and has not previously been associated with pulmonary ossification. We describe a case of diffuse pulmonary ossification in association with diffuse alveolar hemorrhage in a man with significant occupational metal exposure.

Histochemical demonstration of aluminum and iron deposition in pulmonary bony tissues in three cases of diffuse pulmonary ossification.

Diffuse pulmonary ossification is a rare condition. We examined three cases of it in Japan, and attempted histochemically to stain for deposition of aluminum and iron in bony tissues. The patients were all female, and in their mid-twenties, mid- eighties, and later teen years. One of the patients had been exposed to heavy metals in her work involving heavy-metal analyses for 18 months. Aluminum staining and Berlin blue staining for iron were performed with dewaxed, undecalcified sections of pulmonary tissues from these three cases. Interestingly, all pulmonary bony tissues from the three cases examined exhibited linear regions of both aluminum and iron deposition in the calcifying fronts or the cement lines of bones. The patient exposed to heavy metals exhibited the most severe aluminum and iron deposition, and also exhibited positive reaction for both aluminum and iron in elastic fibers of blood vessels. Foreign body granulomas with multinucleated giant cells exhibiting elastophagia were also found in this case. This phenomenon, "endogenous pneumoconiosis", appeared to have been the cause of pulmonary hemorrhage in this case, resulting in focal heavy hemosiderosis. It is of great interest that identical patterns of aluminum and iron deposition in hemodialysis patients were found in these three cases, This is the first report on histochemical demonstration of aluminum and iron deposition in diffuse pulmonary ossification, and detailed analysis of additional cases is needed.

Diffuse pulmonary ossification: an uncommon incidental autopsy finding

To determine the incidence of diffuse pulmonary ossification (DPO) and its subtypes at autopsy and correlation with clinical and histological features. Autopsy reports from our institution over a 64-month period were reviewed for findings of DPO. The pattern of ossification, demographics and clinical data were obtained from both paraffin sections and final autopsy reports. In a selected case, chest radiograph and wet tissue were obtained. Seventeen histologically confirmed cases of DPO were found in 10,426 autopsy cases, representing an incidence of 1.63 cases/1000 autopsies. There was a predilection in males (88%) and underlying pulmonary disease (88%). In contrast to published studies, dendriform DPO was more common than the nodular type in our cohort (11 and 6 cases, respectively). The dendriform type was more commonly associated with marrow elements. Diffuse pulmonary ossification is uncommon and rarely diagnosed during life, but can easily be identified when sectioning the lungs at autopsy. There is recent renewed interest in diagnosing and determining the significance of DPO using high resolution computed tomography and thoracoscopic biopsy.