Case Of Candida Endocarditis Research Articles

Candida endocarditis: systematic literature review from 1997 to 2014 and analysis of 29 cases from the Italian Study of Endocarditis

ABSTRACTIntroduction: Candida Endocarditis (CE) is a deadly disease. It is of paramount importance to assess risk factors for acquisition of both Candida native (NVE) and prosthetic (PVE) valve endocarditis and relate clinical features and treatment strategies with the outcome of the disease.Areas covered: We searched the literature using the Pubmed database. Cases of CE from the Italian Study on Endocarditis (SEI) were also included. Overall, 140 cases of CE were analyzed. Patients with a history of abdominal surgery and antibiotic exposure had higher probability of developing NVE than PVE. In the PVE group, time to onset of CE was significantly lower for biological prosthesis compared to mechanical prosthesis. In the whole population, greater age and longer time to diagnosis were associated with increased likelihood of death. Patients with effective anti-biofilm treatment, patients who underwent cardiac surgery and patients who were administered chronic suppressive antifungal treatment showed increased survival. For PVE, moderate active anti-biofilm and highly active anti-biofilm treatment were associated with lower mortality.Expert commentary: Both NVE and PVE could be considered biofilm-related diseases, pathogenetically characterized by Candida intestinal translocation and initial transient candidemia. Cardiac surgery, EAB treatment and chronic suppressive therapy might be crucial in increasing patient survival.

A case of candida endocarditis, successfully treated with mitral valve replacement and fluconazole.

A case of candida endocarditis, successfully treated with mitral valve replacement and fluconazole.

Candida Endocarditis Of the Tricuspid Valve

To the Editor.— It has been suggested that Candida organisms are ordinarily incapable of initiating infection on a normal valve. 1 Review of the literature revealed five cases of Candida endocarditis that appeared to have solely involved the tricuspid valve. 2-6 An underlying endocardial lesion invariably preceded these fungal infections. In this respect, our own case was exceptional. Report of a Case.— Endocarditis was discovered postmortem in a 77-year-old man with chronic obstructive lung disease of 15 years' duration. There was no past history of congenital heart disease, rheumatic fever, cardiac catheterization, trauma, or surgery of the heart, bacterial endocarditis, diabetes mellitus, or steroid treatment—all known to be predisposing factors in Candida endocarditis. However, recurrent pulmonary infections with a variety of bacterial organisms required treatment with multiple antibiotics, including penicillin, streptomycin, ampicillin, and cephalothin sodium. His terminal admission was prompted by an acute cardiorespiratory decompensation of five days' duration. Cyanosis,

Candida endocarditis after heart surgery.

Four new cases of Candida endocarditis after heart surgery are described and predisposing factors are discussed. Details are given of the one patient diagnosed in life and treated successfully with amphotericin B.

Candida infection as a complication of heart surgery. Review of literature and report of two cases.

Bacterial endocarditis following cardiac surgery is a well-known clinical entity. Recent reports indicate a number of Candida endocarditis cases have been seen as a complication of cardiac surgery. The literature is reviewed, and 2 additional cases of Candida endocarditis are reported. One patient developed a mycotic aneurysm of the aorta following open operation for correction of aortic stenosis. This patient had widespread mycotic emboli and died suddenly following rupture of the mycotic aneurysm of the aorta. The second patient developed a Candida blood stream infection following repair of a ventricular septal defect. This patient recovered after treatment with amphotericin-B. Possible portals of entry of the infection are cardiac catheterization, cardiopulmonary by-pass, and prolonged intravenous fluids.