Cases Of Benign Prostatic Hypertrophy Research Articles

Evaluation of the role of injection therapy for benign prostatic hypertrophy.

Intraprostatic phenol injection treatment was given to 13 cases of benign prostatic hypertrophy (BPH) without urinary retention. Symptomatic improvement was significant, although objective assessment showed neither significant alteration in the size of the prostate nor in the urinary flow rate. Injection therapy is considered inadequate in the relief of prostatic obstruction.

Clinical studies on serum lipids in the patients with tumor of the prostate gland. 1st Report: Serum lipids and lipoprotein fraction levels in the patients with benign prostatic hypertrophy and prostatic cancer (author's transl)

We studied the distribution of serum cholesterol, triglycerides, phospholipids, free fatty acid and serum lipoprotein fraction levels after more than 12 hours' fasting in 189 cases of benign prostatic hypertrophy and 29 cases of untreated prostatic cancer, who were not complicated with cardiovascular disturbances, and additionally in 17 cases of the benign prostatic hypertrophy complicated with cardiovascular disease and 28 cases of other non-advanced urogenital tumors (23 cases of bladder tumor, 3 cases of kidney cancer and 2 cases of testicular tumor). All the patients were over 50 years old. Lipoprotein fractions were measured by agarose-gel-electrophoresis. The results were as follows;1) The serum lipid values of the group of benign prostatic hypertrophy without cardiovascular disturbances did not show any significant differences from the values of 43 cases of the control group. In lipoprotein fractions, β-lipoprotein fraction values were found to be lower than those of the control group, but within the normal range.2) The fluctuations of serum lipids and lipoprotein fractions with age were observed in the group of benign prostatic hypertrophy without cardiovascular disturbances as well as those in 447 cases of Japanese healthy elder males.3) In the prostatic cancer group, the serum lipids levels were not particularly different from the other groups except for the group of benign prostatic hypertrophy complicated with cardiovascular disturbances, while in lipoprotein fractions, some significant increase of β+Pre-β/α lipoprotein fraction ratio was observed. Also, there was observed a high frequency of hyperlipoproteinemia, actually as high as in the group of benign prostatic hypertrophy complicated with cardiovascular disturbances.In view of the above results, differences of β+Pre-β/α lipoprotein fraction ratio between the group of benign prostatic hypertrophy without cardiovascular disturbances and the group of prostatic cancer was clearly observed. The fact that there were many cases who already had hyperlipoproteinemia in the prostatic cancer group was an interesting finding, when this is considered together with the fact that cardiovascular complications are caused by estrogen treatment to the patients with carcinoma of the prostate.

Tissue culture of benign and malignant human prostatic tumors. I. Morphological observation on cultured cells (author's transl)

Prostatic tissues from 34 patients who were suspected to suffer from prostatic cancer were obtained by either rectal or perineal needle biopsy. The tissues were minced into small explants and were placed in T-D 15 flasks and were immersed in a culture medium consisting of Eagle's MEM supplemented with 10% calf serum or bovine serum and were placed in an incubator at 37°C. Outgrowth of monolayer cells was observed morphologically by means of an inverted phase-contrast microscope and photographed. Some tissues were fixed and stained for histopathological observation.Histopathological diagnosises of 34 cases were benign prostatic hypertrophy in 14 cases prostatic adenocarcinoma in 16 cases, suspected carcinoma in 2 cases, reticulum cell sarcoma in 1 case and chronic prostatitis in 1 case.As the results of tissue culture, 4 cases of benign hypertrophy, 11 cases of prostatic adenocarcinoma and 1 case of reticulum cell sarcoma formed monolayer cell sheet over 2 weeks. Therefore, the successful rate was statistically higher in prostatic carcinoma (68.8%) than in hypertrophy (28.6%).In phase contrast microscopy, both the polygonal epithelial cells and the spindle-shaped fibroblastic cells were observed in all the cases of benign prostatic hypertrophy. On the contrary, epithelial cells were dominant in 6 cases of prostatic adenocarcinoma while both the epithelial and the fibroblastic cells were equivalent in other 5 cases of adenocarcinoma. The rate of appearance of the epithelial cells tended to be higher in the adenocarcinoma than in the hypertrophy. All cells in reticulum cell sarcoma were epithelial cells.Although no established cell line was obtained due to infection, many cell strains were obtained from both the biopsied tissues of benign prostatic hypertrophy and prostatic adenocarcinoma, which were maintained in vitro for more than 2 weeks. These cell strains can be used as the experimental models to study the effects of sex hormones upon the prostatic cells.

Clinical study of urethral pressure profile (author's transl)

Pre-and post-operative urethral pressure profile in various lower uropathies, obtained by Brown's method was analyzed for urethral length and pressure in the external sphincteric area.1) The posterior urethral length in normal male was 3.6cm (2.0-4.5cm) on the average, and pressure in the external sphincteric area was 30mmHg (20-42mmHg).2) The average posterior urethra was lengthened to 4.3cm (3.0-7.0cm) and the average pressure at the external sphincteric area increased to 39mmHg (20-50mmHg) in 16 cases of benign prostatic hypertrophy and 3 cases of prostatic carcinoma. There was a marked reduction in both length and pressure in postoperative profile.3) In vesical neck contracture, preoperative urethral length was 4.0cm (3.0-4.5cm) and pressure was 35mmHg (28-50mmHg). The postoperative reduction in length and pressure was less marked comparing to the prostatic hypertrophy group.4) In chronic paraplegic patients the length was 1.8cm (1.3-2.5cm) and the pressure was 23.9 (10-36mmHg). The profile was independent of the level of cord lesion and the duration after injury. No difference in profile was observed between the groups with or without subarachnoidal phenol block. The wave and the spike in anterior urethral profile, which were scarecely found in nonparaplegics, were frequently observed.5) The urethral pressure profile offered valuable clues to the identification of the position and the size of anterior urethral diverticulum and urethral stricture, which helped the diagnosis, selection of operative approach and evaluation of postoperative result.6) Pressure at the external sphincteric area of patients with post-prostatectomy incontinence is lower than 10mmHg. No patient with pressure above 14mmHg at this area was incontinent.This is on easily performable method even in the outpatient clinic, and yet the careful analysis of the curvature gives valuable informations as to the management of various lower uropathies.

Nutritional substitution therapy; a new method which prevents prostatic surgery in benign physiological hypertrophy; a preliminary report.

1. From a preliminary series of 100 cases of benign prostatic hypertrophy, 4 cases have been selected for detailed discussion, representing age groups from 20–71 years. 2. In 2 of these cases prostatic hypertrophy, itself, was prevented; in the third case surgery had previously been recommended as urgent, but was averted by massages plus complete replacement therapy with vitamins, hormones and amino acids; in contrast, the fourth case refused replacement therapy until too late to prevent surgery. 3. Detailed successful therapeutic measures are described in the first three cases. 4. A control group of 107 cases in a similar age group were followed. Of this group 58 per cent required surgery for acute obstruction due to benign prostatic hypertrophy. Another 8 per cent having acute obstruction were carried along by frequent catheterization. 5. The absolute necessity for restoring physiological balance by nutritional replacement therapy, the importance of eradicating all infectious foci in order to maintain a good nutritional level, and the advisability of follow up examinations with booster courses of parenteral therapy in conjunction with prostatic massage is urgently recommended. 6. By this therapeutic approach a method for prevention of all surgery for simple hypertrophied benign prostatitis is demonstrated and presented for consideration.

THE NAUSEA AND VOMITING FOLLOWING ADMINISTRATION OF DIETHYLSTILBESTROL

My purpose in this paper is twofold: First, a definite relation is shown to exist between the nausea and vomiting of early pregnancy and the nausea and vomiting which frequently follows the administration of diethylstilbestrol. Second, a method is described by which diethylstilbestrol may be administered with elimination of side effects in those patients who do not tolerate the drug. RELATION OF NAUSEA OF PREGNANCY TO NAUSEA FOLLOWING DIETHYLSTILBESTROL The clinical material used for this report consists of 95 patients given diethylstilbestrol for periods ranging from three months to two years. Diagnoses include the menopause (natural, surgical and irradiation), hypo-ovarianism, dysmenorrhea, vulvovaginitis of young girls, senile vaginitis, inhibition of lactation (postpartum), menometrorrhagia and 9 cases of benign prostatic hypertrophy. As the investigation progressed it was observed repeatedly that patients who previously had experienced nausea and vomiting in excessive degrees during pregnancy also had nausea and vomiting following