Purpose: Speech-language pathologists (SLPs) are tasked with integrating the principles of evidence-based practice (EBP) to provide effective and efficient assessment and intervention services that best support clients and their families. As new research, technologies, and perspectives emerge, SLPs are required to adapt their clinical practices to meet these changes while maintaining high-quality evidence-based services. Through an illustrative case study, we aim to demonstrate the process of applying EBP principles—including research evidence, client and family perspectives, and clinical expertise—to a complexity-based speech sound intervention delivered via telepractice. Conclusions: Results of the case study suggest that utilizing the principles of EBP to transition an evidence-based complexity intervention to telepractice was successful. Additionally, the EBP framework provided opportunities for reflection and continued adaptation throughout the intervention. The process of applying an EBP framework to a quickly evolving clinical practice environment provides SLPs with essential tools that ensure their services meet the needs of the clients they serve.