Case Of Spontaneous Remission Research Articles

A Case of Hashimoto’s Encephalopathy Presenting with Extrapyramidal Symptoms and Spontaneous Remissions

Hashimoto’s encephalopathy is a rare disease which is attributed to be related with Hashimoto’s thyroiditis and characterized by neurological and psychiatric symptoms, high levels of anti-thyroid antibodies, abnormal electroencephalography, and non-specific imaging findings with good response to corticosteroid therapy. In this article, we report a 72-years-old male case who experienced acute neurologic episodes including extrapyramidal findings, diplopia, dysarthria, ataxia and mild impairment in cognitive functions, followed by spontaneous remissions and was diagnosed as Hashimoto’s encephalopathy in his last episode. We present this case both to emphasize this rare neurological case and the unusual case of spontaneous remission reported in Hashimoto’s encephalopathy.

The development remission of acromegaly in the outcome of intraoperative bleeding in somatoprolactinomas

In this article we describe a rare case of spontaneous remission of acromegaly as a consequence of hemorrhage to pituitary adenoma and subarachnoid space, followed after intraoperative bleeding during transnasal removal of somatoprolactinomas.

A Case of Spontaneous Remission of Acute Pulmonary Embolism

Acute pulmonary embolism (PE) ranges from asymptomatic to often fatal, incidentally discovered emboli to massive embolism causing immediate death. Acute PE may occur rapidly and unpredictably and may be difficult to diagnose. Mortality and complications can be reduced by prompt diagnosis and therapy. Untreated PE is associated with a mortality rate of approximately 30 percents. Most patients with PE have endogenous fibrinolysis, although it is not effective enough to prevent PE. A case of spontaneous remission of untreated acute PE has not previously been reported. Here we present a case of spontaneously resolved acute PE without any treatment.

Nodal Anaplastic Large-Cell Lymphoma ALK-1− with CD30+ Cutaneous Lymphoproliferation Treated with Mistletoe: Spontaneous Remission or Treatment Response?

A 12-year old girl presented with general weakness and weight loss, a localised cervical lymph node enlargement and cutaneous lesions compatible with lymphomatoid papulosis (LyP). Biopsies from lymph node and skin revealed a histological diagnosis of nodal large cell ALK-1- anaplastic lymphoma (ALCL) with a synchronous CD30+ cutaneous lymphoproliferation consistent with lymphomatoid papulosis (LyP). The girl was treated with mistletoe (MT) as monotherapy. Within 1 week after initiation of MT-treatment the skin lesions and lymph node enlargement improved. Under continuing MT-therapy 30 months after diagnosis the patient is still in complete remission. It is not possible to know whether this was a rare case of spontaneous remission of the nodal and skin-manifestations of this CD30+ T-cell lymphoproliferation or whether the observed effect was a specific therapeutic response to MT-treatment.

The Schnitzler syndrome

The Schnitzler syndrome is a rare and underdiagnosed entity which is considered today as being a paradigm of an acquired/late onset auto-inflammatory disease. It associates a chronic urticarial skin rash, corresponding from the clinico-pathological viewpoint to a neutrophilic urticarial dermatosis, a monoclonal IgM component and at least 2 of the following signs: fever, joint and/or bone pain, enlarged lymph nodes, spleen and/or liver, increased ESR, increased neutrophil count, abnormal bone imaging findings. It is a chronic disease with only one known case of spontaneous remission. Except of the severe alteration of quality of life related mainly to the rash, fever and pain, complications include severe inflammatory anemia and AA amyloidosis. About 20% of patients will develop a lymphoproliferative disorder, mainly Waldenström disease and lymphoma, a percentage close to other patients with IgM MGUS. It was exceedingly difficult to treat patients with this syndrome until the IL-1 receptor antagonist anakinra became available. Anakinra allows a complete control of all signs within hours after the first injection, but patients need continuous treatment with daily injections.In many aspects, the Schnitzler syndrome resembles the genetically determined auto-inflammatory syndromes involving activating mutations of the NLRP3 inflammasome. This latter point and its consequences will be addressed.

Improvement of non-paraneoplastic voltage-gated potassium channel antibody-associated limbic encephalitis without immunosuppressive therapy

We describe a 61-year-old patient with clinical evidence of limbic encephalitis who improved with anticonvulsant treatment only, that is, without the use of immunosuppressive agents. Three years following occurrence of anosmia, increasing memory deficits, and emotional disturbances, he presented with new-onset temporal lobe epilepsy, with antibodies binding to neuronal voltage-gated potassium channels and bitemporal hypometabolism on FDG-PET scan; the MRI scan was normal. This is most likely a case of spontaneous remission, illustrating that immunosuppressive therapy might be suspended in milder courses of limbic encephalitis. It remains open whether treatment with anticonvulsant drugs played an additional beneficiary role through the direct suppression of seizures or, additionally, through indirect immunomodulatory side effects.

Bilateral nodular pulmonary granulomas and retroperitoneal fibrosis. Simulated metastatic malignant neoplasm and spontaneous remission of ureteral obstruction.

AN APPARENTLY HOPELESS SITUATION L thought to be due to malignant neoplasm occasionally is deceiving and, therefore, irrefutable pathologic evidence of malignancy is sought before one is resigned to therapeutic nihilism. The following report of a case supports this principle, as the patient was admitted to the University of Chicago Hospitals almost 3 years ago, anuric and with bilateral pulmonary masses presumed to be metastases. She is alive and well today without evidence of malignant disease and represents, to our knowledge, the first case of spontaneous remission in proved retroperitoneal fibrosis as well as an example of unusual, multiple, bilateral, nodular, pulmonary granulomas. Report of a Case First Hospital Admission, Sept. 21, 1959.—A 51-year-old white woman with anuria of 2 days' duration was well until 5 months prior to admission, when she noted bilateral low back pain which became progressively worse but was not associated with dysuria, hematuria, or fever.