Case Of Pulmonary Carcinosarcoma Research Articles

Pulmonary Carcinosarcoma: A Rare Disease With Challenging Diagnosis and Treatment

Pulmonary carcinosarcoma (PCS) is a rare type of non-small cell cancer. Overall, middle-aged and older smokers are the most affected age and sex groups. The diagnosis of PCS is difficult due to the absence of characteristic imaging findings. Additionally, preoperative biopsies do not usually reflect the heterologous nature of this tumor. Given the rarity of such tumors and the challenging diagnosis, the prognostic factors have not been established, and the overall prognosis remains poor. The valid therapeutic options are still limited. Here, we report a rare case of metastatic PCS that was accidentally discovered by imaging and properly diagnosed after surgical resection. The clinicopathological features, diagnostic tools, genetic theories, prognosis, and therapeutic options of this rare cancer are also discussed.

A Case of Pulmonary Carcinosarcoma in a Never-Smoking Elderly Woman

A Case of Pulmonary Carcinosarcoma in a Never-Smoking Elderly Woman

18FDG PET/CT in pulmonary arcinosarcoma and rain etastasis.

Carcinosarcoma is a rare type of cancer that is composed of a mixture of sarcomatous and carcinomatous elements. Pulmonary carcinosarcoma has a 25% five-year survival rate with a prognosis poorer than other non-small cell lung carcinomas. Herein, we report a case of pulmonary carcinosarcoma and its 18F-FDG PET/CT findings. A 61-year-old male patient presented with brain symptoms, including headache, nausea, right hemiplegia, and few attacks of seizures. He underwent brain computed tomography (CT) scan showing a brain lesion in the left parietal lobe. The patient underwent excisional biopsy, and brain lesion was removed. The results of tissue sampling were indicative of carcinosarcoma. Based on anatomical imaging and evidence of pulmonary lesion, the patient underwent 18FDG PET/CT that revealed a heterogeneous mass on the upper lobe of the left lung. An intense FDG uptake was observed along the rim of the mass; however, no FDG uptake was observed in the center of the mass. There were multiple mediastinal lymph nodes with a high FDG uptake. Pulmonary carcinosarcoma was confirmed by tissue sampling.

Significant benefit of Nivolumab treating PD-L1 positive metastatic pulmonary carcinosarcoma: a case report and literature review.

Immunotherapy has recently become a new focus for the treatment of malignant tumors following the surgery, chemotherapy, radiotherapy, and molecular targeted therapy. Nivolumab, a human monoclonal antibody, is the first programmed cell death protein-1 (PD-1) inhibitor, which can prohibit the interaction of its ligand (PD-L1), restoring the immune response of T cells, and enhancing the recognition of tumor cells by the immune system. Pulmonary carcinosarcoma is an uncommon but highly aggressive tumor type with a poor prognosis. We described a case of pulmonary carcinosarcoma, with the positive expression of PD-L1, obtained a significant benefit from Nivolumab treatment in a 64-year-old Chinese man, which give us a clue that patients with pulmonary carcinosarcoma may benefit fromanti-PD-1 immunotherapy.

Carcinosarcoma of the Lung Associated with Tuberculosis

Carcinosarcoma is an uncommon mixed tumor of the lung. It is composed of a mixture of carcinoma and sarcoma elements. We present a case of 64-year-old male with carcinosarcoma of the lung associated with tuberculosis involvement of the same site. The patient was admitted for cough, malaise and fever. Bronchial lavage culture revealed M. tuberculosis. Six months after completion of tuberculosis treatment, the patient was admitted for hemoptysis and headache. CT revealed a solid lesion at the left upper lobe anterior bronchus. Histopathologic examination of the bronchial biopsy specimen revealed carcinosarcoma. Cranial MRI showed a metastatic lesion in the cerebellum which was removed surgically. Four months later, the patient developed bilateral malignant pleural effusions, recurrent cerebellar and skeletal metastases and died in the intensive care unit following intubation for respiratory failure. We describe a case of pulmonary carcinosarcoma occurring at the same localization shortly after successful treatment of tuberculosis with reference to relevant literature.

Carcinosarcoma of lung

Primary carcinosarcoma of the lung is exceedingly rare. It is described as malignancy composed of a mixture of carcinoma and sarcoma elements. The sarcomatous element is usually spindle cell but may contain cartilage, bone or skeletal muscle. We report a case of pulmonary carcinosarcoma in a 66 years male who presented with cough, chest pain on exertion, anorexia and weight loss. Brush cytology revealed poorly differentiated non-small cell carcinoma. Histopathological examination showed proliferation of malignant spindle cells containing bone and malignant cartilage admixed with areas of keratinized squamous cells with few foci of ill-defined glandular structure. On immunohistochemistry, carcinomatous component of tumor showed positivity for cytokeratin AE1/AE3 and spindle cell component were positive for vimentin. These findings led to diagnosis of carcinosarcoma. Journal of Pathology of Nepal (2013) Vol. 3, No.1, Issue 5, 419-421 DOI: http://dx.doi.org/10.3126/jpn.v3i5.7873

A Case of Pulmonary Carcinosarcoma with Polypoid Tumor into Bronchus Diagnosed by Transbronchial Lung Biopsy

A Case of Pulmonary Carcinosarcoma with Polypoid Tumor into Bronchus Diagnosed by Transbronchial Lung Biopsy

Pulmonary Carcinosarcoma

We present a case of pulmonary carcinosarcoma. The patient is a 31-year-old man with a history of infectious mononucleosis in whom a right lung mass was found. His age is lower than the mean age at which pulmonary carcinosarcoma is usually reported. Chest CT scan showed a lobulated 29-mm mass in the right upper lung and multiple hypervascular liver nodules. FDG PET/CT showed increased FDG uptake in the right upper lung nodule (SUVmax, 4.1). However, the hepatic radiouptake showed only background activity. The liver nodules were stable at the 1-year follow-up period and were suggestive of hemangiomas.

A Case of Pulmonary Carcinosarcoma with Calcification in the Tumor Observed on Computed Tomography

背景．肺癌肉腫は癌腫と異所性成分を含む肉腫の混在からなる比較的稀な腫瘍であり，その画像診断に関する報告は少ない．症例．66歳，男性．右肩痛，労作時呼吸困難を主訴に来院した．胸部X線写真にて右大量胸水を認めた．胸部CTでは右胸水および右下肺に空洞を伴う巨大な腫瘤を認めた．胸水細胞診にて悪性細胞を認め，cT3N0M1a，stage IVの肺癌と診断した．化学療法（CBDCA+GEM）を開始したが，初診時より6か月目に施行した胸部CTでは腫瘤は急速に増大し，新たに腫瘤内部に石灰化の出現を認めた．その後，全身状態の悪化に伴い7か月目に永眠された．剖検では最大径25 cmの巨大充実性腫瘤が右胸腔内全体を占拠していた．組織では扁平上皮癌成分，線維肉腫成分，軟骨肉腫成分，骨肉腫成分，横紋筋肉腫成分を認め，肺癌肉腫と診断した．CT上，石灰化を示す部位には腫瘍性類骨および骨形成を示す骨肉腫成分を認めたことから，この石灰化は骨肉腫成分の腫瘍骨に相当した．結論．経過中に腫瘤内部に石灰化の出現を観察し得た肺癌肉腫の1例を経験した．癌肉腫では，骨肉腫成分により，画像上，石灰化を示す場合がある．

A Case of Pulmonary Carcinosarcoma with Multiple Carcinomatous and Sarcomatous Components

A Case of Pulmonary Carcinosarcoma with Multiple Carcinomatous and Sarcomatous Components

A Case of Pulmonary Carcinosarcoma After Surgery for Breast Cancer

背景．肺癌肉腫は肺悪性腫瘍の中でも稀な疾患であり，手術以外に有効とされている治療法も確立されておらず，予後不良である．症例．65歳，女性．61歳時，右乳癌にて非定型乳房切除術を施行された．3年11ヵ月後，経過観察のための胸部CTにて右肺S3領域に約3 cmの腫瘤を認めた．気管支鏡検査では原発性肺腺癌が疑われ，右肺上中葉切除，ND2aを施行した．病理組織診断では低分化腺癌に軟骨肉腫の混在する肺癌肉腫，T2N1M0 p-stage IIBと診断された．術後gemcitabineによる補助化学療法を施行した．同手術の2年1ヵ月後，乳癌大腿骨転移と両側多発肺腫瘤影を認めた．一元的に考え乳癌の肺転移と判断し，TS-1®，carboplatin，paclitaxel，docetaxelによる化学療法を追加したが，肺癌肉腫術後，3年6ヵ月に呼吸不全となり死亡した．結論．乳癌術後に認めた肺癌肉腫の1例を経験し，報告した．

Retrospective analysis of pulmonary sarcoma and blastoma with review of literatures

Objective: To explore the clinical characteristics, diagnosis and treatment of pulmonary sarcoma and blastoma. Methods: Seven cases of pulmonary sarcoma (including 1 case of pulmonary carcinosarcoma, 1 case of pulmonary malignant fibroneuroma, 1 case of pulmonary malignant fibrous tissue tumor and 1 case of pulmonary blastoma from August 1995 to June 2002 in our hospital) were retrospectively summarized the histological characteristics, clinical features, diagnosis and treatment. Results: Pulmonary sarcoma and blastoma both are rare malignant tumors and can be easily misdiagnosed or mistreated. The main symptoms of both diseases are cough and expectoration. X ray or CT shows node or focus in lung. They both are diagnosed by histological pathology. Because the symptoms of these diseases are not typical, it is difficult for patients to be diagnosed without pathology. Conclusion: These two kinds of diseases are often easy to be misdiagnosed. Early diagnosis and treatment are important to improve the efficiency of treatment. Surgical resection is the best method of treatment, and it is important to combine with chemotherapy and radiation treatment.

A Case of Pulmonary Carcinosarcoma which Metastasize to Pelvic Cavity After Left Pneumonectomy

Pulmonary carcinosarcoma(Sarcomatoid carcinoma of the lung) is a rare pulmonary malignancy, which is defined as having an admixture of both carcinomatous and sarcomatous components. Pulmonary carcinosarcoma occurs most frequently in males between 50 and 80 years of age. It predominantly affects the upper lobe and/or the principal bronchi, and is associated with a history of smoking. Here, we report a case of pulmonary carcinosarcoma with a left lobe atelectasis due to an endobronchial mass in a 56-year-old male. After a left pneumonectomy, the pathologic stage was IIb (). Four months later, an abdominal mass was observed and exploratory laparotomy revealed metastases of the pulmonary carcinosarcoma to the pelvic cavity.

A Case of Pulmonary Carcinosarcoma Associated with Alternate Atelectasis

Carcinosarcoma is an uncommon pulmonary malignancy characterized by carcinomatous parenchyma and sarcomatous stroma. Pulmonary carcinosarcoma represented about 1% of the resected lung tumors. The predominant clinical features are productive cough, chest pain, dyspnea, hemoptysis, bronchiectasis, and atelectasis, but alternate atelectasis is rare. We report a case of pulmonary carcinosarcoma associated with alternate atelectasis of the right upper and lower lobe.