Abstract
Carcinosarcoma is an uncommon mixed tumor of the lung. It is composed of a mixture of carcinoma and sarcoma elements. We present a case of 64-year-old male with carcinosarcoma of the lung associated with tuberculosis involvement of the same site. The patient was admitted for cough, malaise and fever. Bronchial lavage culture revealed M. tuberculosis. Six months after completion of tuberculosis treatment, the patient was admitted for hemoptysis and headache. CT revealed a solid lesion at the left upper lobe anterior bronchus. Histopathologic examination of the bronchial biopsy specimen revealed carcinosarcoma. Cranial MRI showed a metastatic lesion in the cerebellum which was removed surgically. Four months later, the patient developed bilateral malignant pleural effusions, recurrent cerebellar and skeletal metastases and died in the intensive care unit following intubation for respiratory failure. We describe a case of pulmonary carcinosarcoma occurring at the same localization shortly after successful treatment of tuberculosis with reference to relevant literature.
Highlights
Pulmonary carcinosarcoma is an exceedingly rare tumor of the lung, comprising approximately for only 0.2% 0.3% of all lung malignancies [1] [2]
We report a case of pulmonary carcinosarcoma occurring shortly after successful treatment of pulmonary endobronchial tuberculosis
We believe that our case is unique that previous old or recent tuberculosis infection may be associated with pulmonary carcinosarcoma
Summary
Pulmonary carcinosarcoma is an exceedingly rare tumor of the lung, comprising approximately for only 0.2% 0.3% of all lung malignancies [1] [2]. (2015) Carcinosarcoma of the Lung Associated with Tuberculosis. Case Reports in Clinical Medicine, 4, 321-326. Lung cancer risk has been reported to be increased among persons with a history of tuberculosis, pulmonary fibrosis and chronic obstructive pulmonary diseases [5]-[7]. Malignancies especially adenocarcinomas are well documented complications of chronic inflamatory states and association between pulmonary tuberculosis with consequent development of lung cancer has been reported, pulmonary carcinosarcoma occurring at the same site occurring shortly after successful treatment of pulmonary tuberculosis has not been described previously. We report a case of pulmonary carcinosarcoma occurring shortly after successful treatment of pulmonary endobronchial tuberculosis
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