Case Of Primary Intraosseous Carcinoma Research Articles

A rare case of primary intraosseous carcinoma of the mandible with perineural extension mimicking neurolymphomatosis on [18F]-FDG PET/CT.

A rare case of primary intraosseous carcinoma of the mandible with perineural extension mimicking neurolymphomatosis on [18F]-FDG PET/CT.

Primary intraosseous squamous cell carcinoma arising in odontogenic cysts: A report of five cases and a review of the literature

Primary intraosseous carcinoma (PIOC) is rare entity with an estimated incidence of 0.01-0.02% of all oral cancer. To date, 133 PIOC cases have been reported with most occurring in the setting of periapical/residual cysts. Distinc- tion from carcinomas arising from the oral or antral mucosa may be difficult, especially when the cortical plates have been destroyed. Therefore, signs of oral ulceration preclude the diagnosis of PIOC. Identification of a benign cystic structure exhibiting transition to a squamous cell carcinoma may be of help in establishing the diagnosis and etiology of the tumor. The aim of our study was to evaluate the cases of only primary intraosseous squamous cell carcinomas arising in odontogenic cysts diagnosed in the Oral Pathology Laboratory at New York Presbyterian Queens between 1995-2019 with the goal of adding valuable information to the literature for this uncommon en- tity. Five cases of PIOC were identified. For each case the histology, demographics, radiographic descriptions and radiographs when possible were reviewed. In all cases, transition from a cystic structure to infiltrating carcinoma was identified. In no case did the overlying surface mucosa exhibit dysplastic changes or transition to carcinoma. Four cases occurred in the maxilla and one in the mandible. The average age of patients in this study was 67.6 years with a range of 37 to 81. Three patients were males and two were female. Three cases presented as ill-defined radiolucencies and one was described as a cystic expansion. Two PIOCs arose in the setting of a periapical cyst, one in the setting of a residual cyst and one in the setting of a dentigerous cyst. Two cases had associated bone loss. While uncommon, the possibility of carcinoma arising in what appears clinically to be a cyst, supports the need to submit all tissue for microscopic examination.

Primary intraosseous squamous cell carcinoma arising in odontogenic cysts: a series of three cases with immunohistochemical analysis

<h3>Introduction</h3> Carcinomatous transformation in odontogenic cysts is rare, with few cases described in the literature. Squamous cell carcinoma (SCC) is the most common form of malignant transformation in odontogenic cysts. Radicular and dentigerous cysts are the most common odontogenic cysts to undergo malignant transformation. We present three cases of primary intraosseous carcinoma (PIOC) arising in odontogenic cysts. <h3>Method and Materials</h3> Following IRB approval, cases were identified from the University of Florida Biopsy Service archives (1994-2020). The clinical and demographic data was reviewed, along with radiographs and original slides. An immunohistochemistry (IHC) panel including CK19, p53, and Ki-67 was performed on all cases. <h3>Results</h3> The first case occurred in a 67-year-old male with a radiolucency around impacted #17. Microscopically, a verrucous carcinoma was diagnosed arising within a developmental odontogenic cyst, most likely an orthokeratinized odontogenic cyst. The second case involved a 59-year-old male with a lesion adjacent to tooth #15. Histologic examination revealed a well differentiated SCC arising from an odontogenic keratocyst (OKC). The final case involved a 13-year-old male with a radiolucency near teeth #6-7. A well differentiated SCC was diagnosed arising from an OKC. Further investigation to assess for Nevoid Basal Cell Carcinoma Syndrome was recommended for this case, but the outcome was unavailable. IHC analysis revealed P53 positivity for all cases. Ki67 showed 80-90% positivity in the basal layer of the odontogenic epithelium for cases 1 and 3, and 50% positivity for case two. Ck19 was only focal positivity in all cases. <h3>Conclusion</h3> We present three cases of squamous cell carcinoma arising within odontogenic cysts. P53 and Ki-67 positivity aid in confirmation of the aggressive nature of each tumor. CK19 staining was weak, despite the obvious odontogenic nature of the epithelium in all cases. Careful follow-up for odontogenic cysts demonstrating recurrence or progressive growth is imperative.

A case of primary intraosseous carcinoma of the mandible with functional restoration by dental implants after immediate reconstruction using sagittal split sliding osteotomy and coronoid process grafting

A case of primary intraosseous carcinoma of the mandible with functional restoration by dental implants after immediate reconstruction using sagittal split sliding osteotomy and coronoid process grafting

Primary Intraosseous Carcinoma of the Mandible: A Case Report

Primary intraosseous carcinoma (PIOC) is a rare tumor that has been infrequently reported. Carcinoma arising primarily from the jaw is a locally aggressive lesion with poor prognosis. Primary intraosseous carcinoma (PIOC) lesion develops either de novo remnants of odontogenic epithelium, odontogenic cyst/tumor, epithelium remnants, or/and salivary gland residues. This article describe a case of primary intraosseous carcinoma of mandible.

Primary Intraosseous Carcinoma of the Mandible: A Case Report

ABSTRACT&#x0D; Objective: To present a rare case of primary intraosseous carcinoma arising from the mandible and to discuss the ensuing course and the management of the patient.&#x0D; Methods: &#x0D; Design: Case Report&#x0D; Setting: General Tertiary Government Training Hospital&#x0D; Patient: One&#x0D; Result: A 56-year-old man consulted for a right mandibular mass of 4 months that started as a small bony swelling which gradually increased to its present size of 8 x 6 cm. Incisional biopsy revealed invasive squamous cell carcinoma and the patient underwent segmental mandibulectomy and bilateral selective neck dissection (levels 1 to 3). Final histopathologic findings revealed squamous cell carcinoma.&#x0D; Conclusion: Primary intraosseous carcinoma of the mandible was diagnosed since there was no overlying mucosal ulceration, other types of odontogenic carcinoma were ruled out, and no other distant primary tumor was noted from the time of examination until six months post-treatment.&#x0D; Keywords: primary intraosseous carcinoma; squamous cell carcinoma; odontogenic tumor; epithelial rest of Malassez; dental lamina

Techniques in the Safe Use of Polycaprolactone in Structural Rhinoplasty

ABSTRACT&#x0D; &#x0D; Objective: To present a rare case of primary intraosseous carcinoma arising from the mandible and to discuss the ensuing course and the management of the patient.&#x0D; &#x0D; Methods:&#x0D; Design: Case Report&#x0D; Setting: General Tertiary Government Training Hospital&#x0D; Patient: One&#x0D; &#x0D; Result: A 56-year-old man consulted for a right mandibular mass of 4 months that started&#x0D; as a small bony swelling which gradually increased to its present size of 8 x 6 cm. Incisional&#x0D; biopsy revealed invasive squamous cell carcinoma and the patient underwent segmental&#x0D; mandibulectomy and bilateral selective neck dissection (levels 1 to 3). Final histopathologic&#x0D; findings revealed squamous cell carcinoma.&#x0D; &#x0D; Conclusion: Primary intraosseous carcinoma of the mandible was diagnosed since there was no overlying mucosal ulceration, other types of odontogenic carcinoma were ruled out, and no other distant primary tumor was noted from the time of examination until six months post-treatment.&#x0D; &#x0D; Keywords: primary intraosseous carcinoma; squamous cell carcinoma; odontogenic tumor;&#x0D; epithelial rest of Malassez; dental lamina

Genetic and histopathological analysis of a case of primary intraosseous carcinoma, NOS with features of both ameloblastic carcinoma and squamous cell carcinoma

BackgroundPrimary intraosseous carcinoma (PIOC), NOS is an odontogenic carcinoma with unknown etiology. Its diagnosis may be used when central jaw carcinoma cannot be categorized as any other type of carcinoma. Further information on this extremely rare tumor is needed to improve our understanding and evaluate the classification of odontogenic carcinomas.Case presentationWe herein presented two patients with PIOC, NOS with different clinical and histopathological features and analyzed gene mutations in these patients using next-generation sequencing (NGS). The typical PIOC, NOS case had many histopathological similarities to oral squamous cell carcinoma (OSCC), including the missense point mutations of TP53 Glu285Val, KDR Gln472His, and APC Pro1433Leu, which are similar to those in other cancers; however, no mutations were detected in the other patient with an atypical presentation of PIOC, NOS, which was derived from a precursor cystic lesion with similarities to both ameloblastic carcinoma and OSCC.ConclusionsGenetic analysis suggested that these two PIOC, NOS cases have different features and can be subcategorized.

P1.31. Experience with 15 cases of primary intraosseous carcinoma of the jaws

P1.31. Experience with 15 cases of primary intraosseous carcinoma of the jaws

Primary Intraosseous Carcinomaの1例

Primary Intraosseous Carcinomaの1例

P12 Experience with 13 cases of primary intraosseous carcinoma of the jaws

P12 Experience with 13 cases of primary intraosseous carcinoma of the jaws

CT imaging and clinic-pathologic study on primary intraosseous carcinoma of the jaws

目的 提高对原发性颌骨骨内癌的认识.方法搜集临床、手术、病理证实的原发性颌骨骨内癌6例,回顾性分析其CT、临床和病理表现.结果5例发生于下颌骨,1例位于上颌骨.3例CT表现为筛孔状骨质破坏,周围形成软组织肿块.3例表现为大块溶骨性骨质破坏,在一侧形成巨大软组织肿块.2例为鳞癌,4例为腺癌,包括1例乳头状腺癌,1例黏液性乳头状腺癌;2例腺样囊腺癌.结论原发性颌骨骨内癌好发于下颌骨,CT表现为骨恶性肿瘤征象,在颌骨恶性肿瘤中应作为鉴别诊断考虑。

Primary intraosseous carcinoma arising from an odontogenic cyst: A case report and review of the Japanese cases.

A rare case of primary intraosseous carcinoma (PIOC) arising from an odontogenic cyst in a 58-year-old man is reported. Clinical and radiological examinations revealed an odontogenic cyst of the maxilla. Histopathologically, the lesion was composed of a cyst with a parakeratotic epithelial lining and well-differentiated squamous cell carcinoma, showing continuity between them without a connection to the oral mucosa. Twenty-eight well-documented Japanese cases of Type-1 PIOC, including the present case, were reviewed. The mean age of the 28 patients was 56.1 years, and the male to female ratio was 1.8:1.0. Compared with currently reported Japanese reviews of Type-3, foreign Type-1 and Type-3, there were no significant differences in mean patient age and sexual predominance, and no racial difference. The pathogenesis of Type-1 PIOC is also discussed.

A case of primary intraosseous carcinoma of the mandible

A case of primary intraosseous carcinoma of the mandible

顎骨中心性癌の２例

Two cases of primary intraosseous carcinoma (PIOC) are reported. One PIOC developed in the anterior maxilla of a 44-year-old man and appeared as carcinoma arising in a radicular cyst. The other PIOC appeared in the mandible of a 41-year-old man and was diagnosed as a PIOC arising from an odontogenic cyst. The first tumor subsequently metastasized to the regional lymph nodes. However, the second tumor did not metastasize to any regional lymph nodes. These patients are free of the disease as of two years and six months and one year and seven months, respectively, after treatment.

Primary intraosseous carcinoma of the jaws. Three new cases and a review of the literature

Three new cases of primary intraosseous carcinoma are presented. The clinical features of these cancers often mimics odontogenic cysts, dental abscesses or periodontal disease; all benign dental conditions. This may delay the diagnosis and probably accounts for the poor prognosis associated with these tumours of 30–40% 5-year survival. A total of 24 cases of primary intraosseous carcinomas have been analysed, which includes reports collected from the literature and the three new cases presented in this paper.