Case Of Primary Adenosquamous Carcinoma Research Articles

Adenosquamous carcinoma of the right colon with diffuse signet-ring mucinous component

Colorectal carcinoma is one of the most frequent human malignant neoplasms. Besides the most common histological types, colorectal adenosquamous carcinoma is very rare, being microscopically constituted by tumoural glandular and squamous components. The diagnosis of primary colon adenosquamous carcinoma requires the exclusion of a metastatic squamous cell carcinoma and the extension of a primary squamous cell carcinoma from the anal-rectum junction. We report a case of primary adenosquamous carcinoma of the ascending colon in a 62-year-old Caucasian man affected by long-standing ulcerative colitis. Peritumoural lymph nodes and distant metastasis were present. We reported also a diffuse signet-ring mucinous component, which has not been previously observed. Moreover, we investigated microsatellite and all-RAS/B-RAF status, p16 and p53 protein expression, and the molecular presence of human papillomavirus DNA in all the morphologically distinct components, in order to suggest pathogenetic factors influencing the aggressive prognosis of colon adenosquamous carcinoma.

A Case of Primary Adenosquamous Carcinoma of the True Vocal Fold Mimicking Atypical Squamous Cell Proliferation

A Case of Primary Adenosquamous Carcinoma of the True Vocal Fold Mimicking Atypical Squamous Cell Proliferation

著明な骨形成を伴った原発性肺腺扁平上皮癌の1例

著明な骨形成を伴う原発性肺癌の1例を経験したので報告する．症例は75歳，女性で，CTにて左上葉に著明な石灰化を伴う腫瘤影を認めていた．経過観察にて増大傾向であったため手術を施行した．病理検査では腫瘍内部に著明な骨形成を伴う腺扁平上皮癌の診断であった．骨形成を伴う原発性肺癌の報告は非常に稀であり，これまで本症例を含めて13例の報告しかなく，腺扁平上皮癌は本症例だけであった．組織所見は症例により様々であり，骨形成の機序についてもBMP2やTGF-βの関与も示唆されているが，不明な点も多い．今後さらなる症例の蓄積により，機序や特徴，予後といった様々な点において検討，解明されることが期待される．

A Case of Adenosquamous Carcinoma of the Cecum

Adenosquamous carcinoma of the colon is rare, accounting for approximately 0.1% of all colon cancers. We present a case of primary adenosquamous carcinoma of the cecum treated with resection. A 73-year-old woman was admitted to the hospital because of abdominal pain and vomiting, and ileus was diagnosed on the basis of colonic obstruction suggested by abdominal X-ray examination. Colonoscopy revealed type 2 advanced cancer of the cecum, and a biopsy confirmed adenocarcinoma. Computed tomography (CT) of the chest and abdomen revealed no distant metastases. The levels of carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) before the operation were 17ng/ml and 101U/ml, respectively. Ileocecal resection (D3) was performed, and the clinical stage of the tumor was IIIb (T3N2H0P0). Pathological examination showed adenosquamous carcinoma (moderately differentiated adenocarcinoma and well-differentiated squamous cell carcinoma) and regional lymph node metastases (No. 201 and 202, positive; No. 203, negative). Adjuvant chemotherapy with 5-fluorouracil (5-FU)/leucovorin (LV) was performed, and the patient was disease-free for 15 months after the operation. However, metastasis to the para-aorta lymph nodes was detected with CT examination 16 months after the operation. The patient received best supportive care and died 22 months after surgery.

A rare case of primary adenosquamous carcinoma arising from ovary

Primary adenosquamous carcinoma of ovary is extremely rare malignancy. We report a case of primary adenosquamous carcinoma of the ovary which has not been reported in Korea before. The case of a 32 year old woman, evaluated for palpable abdominal mass is presented. Ultrasonography, abdomino-pelvic MRI, PET-CT were suggestive of a malignant neoplastic process. Surgical debulking operation including total abdominal hysterectomy, bilateral salpingo-oophorectomy, bilateral pelvic lymph node dissection, para-aortic lymph node biopsy, total omentectomy, incidental appendectomy and low anterior resection of rectum were performed. Histopathology demonstrated primary adenosquamous carcinoma arising from the left ovary to the myometrium, serosa, rectal wall mass and omentum. The staging for ovarian tumor was consistent with FIGO stage IV. We present a case of this rare malignancy

Adenosquamous Carcinoma of the Liver: A Case Report

A case of primary adenosquamous carcinoma of the liver is reported. A large cystic mass with irregrlar enhancing wall was seen in the left lobe of the liver ; multiple hepatic cysts and metastatic nodules were scattered in both lobes. Sonoguided needle biopsy was performed and onhistopathology, adenosquamous carcinoma was diagnosed. The radiologic and pathologic relationships of this unusual neoplasm are discussed.

PRIMARY ADENOSQUAMOUS CARCINOMA OF THE LIVER

A case of primary adenosquamous carcinoma of the liver, a rare type of tumour, is reported. The aetiology and histopathology of this tumour are discussed.

A CASE OF PRIMARY ADENOSQUAMOUS CARCINOMA OF THE RECTOSIGMOIDAL COLON

A case of primary adenosquamous carcinoma of the rectosigmoidal colon is reported and discussed clinicopathologically.A 83-year-old male, who has been visiting a his near practitioner with the chief complaint of diarrhea, admitted to our hospital, because poor appetite and weight-decrease were also gradually developed. Radiological and endoscopic examinations of the lower gastrointestinal tract indicated carcinoma of the rectosigmodial colon. The patient underwent sigmoidoproctostomy. The resected tumor belonged to whole around Borrmann type I with 8.0×10.0 cm in size. Histopathologically it belonged to adenosquamous carcinoma mixdely consisting of well differenciated adenocarcinoma and moderately differenciated squamous cell carcinoma.Adenosquamous carcinoma of the colon occurs so rarely that only 28 cases including this case have been reported in Japan up to now. Our review resulted in that the carcinoma tended to be developed more frequently in youngers, females, and ascending colon, Borrmann type II, and ss or s (+) cases; moreover, that it occurred with squamous cell carcinoma mainly. No theory has been established for mechanism of occurrence, but we support a theory that adenocarcinoma cells are converted to squamous cells.

An adenosquamous carcinoma of the male urethra with hypercalcemia

A case of primary adenosquamous carcinoma of the urethra observed in a 52 year old man is described. The patient had a history of recurrent scrotal abscess for seven and one-half months following trauma to the region. The serum calcium level was found to be elevated when carcinoma was diagnosed. The calcium level returned to normal after resection of the lesion but rose again when local recurrence and metastasis developed. He died three and one-half months after the surgery.

A case of Primary Adenosquamous Carcinoma in the Pancreas

A case of Primary Adenosquamous Carcinoma in the Pancreas