Case Of Polymorphous Low-grade Adenocarcinoma Research Articles

A Case of Polymorphous Low-Grade Adenocarcinoma of the Nasopharynx

A Case of Polymorphous Low-Grade Adenocarcinoma of the Nasopharynx

Polymorphous low-grade adenocarcinoma of the epiglottis: A case report.

Polymorphous low-grade adenocarcinoma is an uncommon malignant tumor derived from the terminal duct cells of the salivary glands. The present study described a rare case of polymorphous low-grade adenocarcinoma, T2N0M0 stage 2, in a 65-year-old man, who presented with a sore throat and painful dysphagia. Computed tomography revealed an infiltrative heterogenous enhancing mass involving the left aryepiglottic fold. He underwent a tumor removal with frozen section for evaluating the surgical margin. Subsequent supraglottic laryngectomy was performed. Polymorphous low-grade adenocarcinoma was diagnosed histologically, characterized by cytologic uniformly, morphologic diversity and an infiltrative growth pattern. Epiglottic cartilaginous invasion by the tumor is demonstrated. Clinical, radiological, endoscopic and pathological features with briefly reviewed relevant literatures are discussed. This is the first reported description in the literature, to the best of our knowledge, of an epiglottic polymorphous low-grade adenocarcinoma receiving successful supraglottic laryngectomy with 7 year disease free survival.

A Case of Polymorphous Low-grade Adenocarcinoma of the Hard Palate

A Case of Polymorphous Low-grade Adenocarcinoma of the Hard Palate

臼後部に発生した多型低悪性度腺癌の1例

臼後部に発生した多型低悪性度腺癌の1例

Polymorphous low-grade adenocarcinoma of the tongue: a case report

IntroductionPolymorphous low-grade adenocarcinoma is a distinct neoplasm of the salivary gland composed of luminal and non-luminal tumor cells admixed in varying proportions. Its resemblance to lobular carcinoma of the breast had led to its earlier nomenclature of 'terminal duct carcinoma'. Most patients present with an asymptomatic mass in the hard palate. In rare cases, the mass can also occur in the tongue. We report an unusual case of polymorphous low-grade adenocarcinoma at the base of tongue.Case presentationA 47-year-old Asian Caucasian woman presented with a painless swelling at the right lateral border of the tongue with an intact overlying mucosa. There were no other associated complaints. The lesion was excised and subjected to histopathological examination that revealed an interesting and unusual morphology of polymorphous low-grade adenocarcinoma.ConclusionPolymorphous low-grade adenocarcinoma is a well-defined entity in the minor salivary glands. Its occurrence in the tongue is rare with very few cases reported in the literature. It is a malignant neoplasm with low aggressiveness and it is thus important to identify and treat it accordingly.

A case of polymorphous low-grade adenocarcinoma of the cheek

A case of polymorphous low-grade adenocarcinoma of the cheek

A case of polymorphous low-grade adenocarcinoma in the palate with similar features to adenoid cystic carcinoma

Background: We report a case of polymorphous low-grade adenocarcinoma (PLGA) of the palate showing features similar to adenoid cystic carcinoma (ACC) in smear cytology.Case and Conclusion: Imprint specimens from the cut surface of biopsied tissue in a 78-year-old woman with a painless mass in the palate contained many neoplastic cells arranged in tight clusters, and mucous ball-like structures, pseudopapillary, tubular, and solid patterns were observed. Cells forming these clusters varied in size and had abundant eosinophilic, granular cytoplasm. Nuclei were round to oval and had a relatively smooth configuration. Although ACC was suspected cytologically, PLGA was confirmed by histopathological section. As opposed to imprint specimens obtained from resected tumors, no indian file arrays or concentric targetoids were detected in the imprint from the biopsied specimen, which thus led to diagnostic failure.

Polymorphous low-grade adenocarcinoma of the tongue

Polymorphous low-grade adenocarcinoma has been recently recognized as a distinct entity with a predilection for minor salivary glands. We present an unusual case of polymorphous low-grade adenocarcinoma of the tongue. Only a few cases located at the tongue have been reported in the English literature. Current literature concerning the histopathological and clinical features of this tumor was discussed.

軟口蓋に発症したｐｏｌｙｍｏｒｐｈｏｕｓ ｌｏｗ‐ｇｒａｄｅ ａｄｅｎｏｃａｒｃｉｎｏｍａの１例

軟口蓋に発症したｐｏｌｙｍｏｒｐｈｏｕｓ ｌｏｗ‐ｇｒａｄｅ ａｄｅｎｏｃａｒｃｉｎｏｍａの１例

上唇に発生したｐｏｌｙｍｏｒｐｈｏｕｓ ｌｏｗ‐ｇｒａｄｅ ａｄｅｎｏｃａｒｃｉｎｏｍａの１例

We describe an unusual case of polymorphous low-grade adenocarcinoma arising from the inner side of the upper lip of a 48-year-old woman. This tumor was firstly reported by Evans and Batsakis (1984) and was adopted as a new entity in the subclassification of adenocarcinoma by the World Health Organization Classification (1991). The clinical course and histopathological and immunohistochemical characteristics are described with a literature review concerning this case. Histologic features include a variety of growth patterns, such as ductal, trabecular, and solid structures. Immunohistochemical analyses showed positive stainings for cytokeratin, vimentin, and S-100 protein. In addition, a few cells forming ductal structures also stained positively for epithelial membrane antigen.

再発と転移を示したＰｏｌｙｍｏｒｐｈｏｕｓ ｌｏｗ‐ｇｒａｄｅ ａｄｅｎｏｃａｒｃｉｎｏｍａの１例

再発と転移を示したＰｏｌｙｍｏｒｐｈｏｕｓ ｌｏｗ‐ｇｒａｄｅ ａｄｅｎｏｃａｒｃｉｎｏｍａの１例

Polymorphous low-grade adenocarcinoma of the sublingual gland

A case of polymorphous low-grade adenocarcinoma occurring in the sublingual gland is described, followed by a brief discussion on the differential diagnosis. This is the first case ever reported of this entity occurring in the sublingual gland. This paper brings into question the early belief that this tumor is restricted to intraoral minor salivary glands.

喉頭に発生したPLGAの1例

Polymorphous Low-Grade Adenocarcinolna (PLGA) は, 小唾液腺由来の低悪性度腺癌で, 病理学的には多彩な組織像を呈する.本腫瘍は肉眼的には境界は比較的明瞭だが, 病理組織学的には被膜形成は弱く周囲組織への浸潤を認める.根治的な摘出が行われれば一般に予後は良好で, 頸部リンパ節転移や遠隔転移を来すことは稀な腫瘍とされている.今回われわれは72歳女性の喉頭蓋に発生したPLGAの症例を経験したので報告した.PLGAは放射線, 化学療法に抵抗性であることから, 外科的切除が唯一の治療である.自験例ではendolaryngeal microsurgery下に, Nd-YAGレーザーを用いて切除を行い良好な経過を得た.

上顎洞に発生したPolymorphous Low-Grade Adenocarcinomaの1症例

上顎洞に発生したPolymorphous Low-Grade Adenocarcinomaの1症例

Polymorphous low‐grade adenocarcinoma of submandibular gland origin

A case of polymorphous low-grade adenocarcinoma (PLGA) in the submandibular gland is reported. A 72 year old woman presented with a 5 year history of a gradually expanding tumor in the submandibular region. The surgical specimen revealed a relatively well demarcated tumor, 35 x 35 x 20 mm in size. Macroscopically, necrosis and hemorrhage were not seen in the solid tumor. Histologically, the tumor growth pattern was variable, composed of tubular, papillary, solid, trabecular and cribriform structures. Immunohistochemically, some tumor cells were positive for epithelial membrane antigen (EMA), S-100 protein, keratin, and carcinoembryonic antigen (CEA). Electron microscopically, prominent microvilli projected into the luminal spaces, and basal lamina and hemidesmosomes were seen in the tumor cells adjacent to the connective tissues. The submandibular gland is an extremely rare location for PLGA. To the authors' knowledge, this is the first case of its kind reported in the English literature.