Pneumomediastinum is an entity with diverse underlying etiologies and variable clinical presentations. We present a case of pneumomediastinum that on initial presentation appeared to be an upper airway emergency most consistent with adult epiglottitis. The pathophysiology of pneumomediastinum involves extravasation of air through perivascular interstitial tissues. Once air has gained access into the soft tissues, it may dissect upward into the neck and distend upper airway structures. This may cause patients with pneumomediastinum to have symptoms such as a sore throat or dysphagia. The patient we describe had such dramatic upper airway symptomatology that adult epiglottitis was the initial suspected diagnosis, and acute airway intervention was required. The various etiologies, presentations, and pathophysiology of pneumomediastinum are discussed.
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