Case Of Multiple Primary Cancer Research Articles

下顎歯肉と直腸の重複癌にさい原嚢胞を伴った１例

下顎歯肉と直腸の重複癌にさい原嚢胞を伴った１例

日本病理剖検輯報に基づく舌癌剖検症例の統計的検討 ＩＩＩ

In order to investigate the real condition of tongue cancer in Japan, a statistical survey was made on autopsied cases of tongue cancer, listed during 5 years (1982-1986) in the Annual of the Pathological Autopsy Cases in Japan. The following results were obtained:1. A total number of 545 cases (Male 409, Female 133, Unknown 3) of tongue cancer were revealed. The average age at death was 59.2 ± 13.2 years in male, and 64.8 ± 14.1 years in female.2. The autopsy rate of the cases with tongue cancer in Japan was 18.4 percent.3. Tongue cancer was found most frequently in the 50-59 year age group (144 cases), followed by 60-69 year age group (142 cases) and 70-79 year age group (123 cases). These age groups totaled 75.0 percent of all cases of tongue cancer.4. As to tongue cancer location, the lateral border was the most frequently affected site, and root of the tongue (30.5%) followed. The average age of cases dying from tongue cancer, originating from the lateral borders, was 61.8 ± 15.0 years; that from the tongue root was 62.2 ± 11.6 years, and that of the anterior site of the tongue was a comparatively advanced age (67.1 ± 11.6).5. Histologically, 98.1 percent of the tongue cancer was squamous cell carcinoma.6. In 43.4 percent of the cases with tongue cancer there was metastases both in the organ and lymph nodes; 33.8 percent of the cases had metastasis only to the organs, and 3.0 percent had metastasis only to the lymph nodes. Concerning the organs, the lung was the most common site (46.7%), followed by cervical soft tissue (22.0%), thyroid (14.6%), pharynx (14.6%), liver (13.8%), pleura (13.8%) and kidney (12.1%). The cervical lymph nodes were most frequently invaded (28.1%), followed by pulmonary hilur (13.3%), paratracheal (8.1%), supraclavicular (6.4%) and mediastinal (4.9%).7. Of all tongue cancers, 117 cases of multiple primary cancers affected both the tongue and other organs were found (double cancer: 96, triplem cancer: 20, quintuple cancer: 1). Common organs with cancer which were combined with tongue cancer were stomach, esophagus, lung, colon, bone marrow, lymphatic tissue, and liver.8. The causes of death not associated with tongue cancer were pneumonia, rupture of vessel, ulcer (perforation) and hemmorrhage in the digestive tract, hemmorrhage by tumor and fungal infection etc.

MULTIPLE PRIMARY CANCERS ASSOCIATED WITH ESOPHAGEAL CANCER

Twelve cases of multiple primary cancer associated with esophageal cancer were registered at Osaka Koseinenkin Hospital from 1968 to 1985. The frequency was 8.7% of all esophageal cancers treated within the same period. Synchronous cancers numbered nine, metachronous cancers three. Eight cases were opearted on for both esophageal and another cancer. The operative results were not satisfactory, including two operative deaths and one hospital death, and a mean survival for the other five cases of 8.4 months. The prognosis of multiple cancers associated with esophageal cancer is extremely poor due to the difficulty of treating esophageal cancer compounded by cancer of other organs, particularly in synchronous cases. A one-stage radical operation for both cancers should be strictly decided upon in consideration of the patient's age, choice of organ for reconstruction, and cardiorespiratory reserve. A two-stage operation may be desirable for reducing the operative burden.

Minimal Genetic Findings and Their Cancer Control Implications

A kindred in which five first-degree relatives were initially known to exhibit colorectal, endometrial, and unspecified carcinoma for two generations, occurring at an early age and including three cases of multiple primary cancer, is consistent with criteria for the cancer family syndrome. Follow-up included a diligent surveillance program that led to the early diagnosis of colon cancer in a young member of the third generation who had been considered at high risk for this lesion. Manifestly, hereditary cancer syndrome identification may be expedited through longitudinal study of apparently cancer-prone kindreds, given limited historical information about tumor expression. However, cancer surveillance measures can and should be instituted early and predicated on clues that suggest, but need not be diagnostic of, such a hereditary cancer predisposing disorder.

A Case of Multiple Primary Cancer of the Larynx and the Stomach

A Case of Multiple Primary Cancer of the Larynx and the Stomach