ASEPARATE term, pituitary myxedema, has been used to describe the condition of hypothyroidism caused by pituitary insufficiency (1, 2). This name has been used, not only because the etiology is different from that of primary hypothyroidism, but because the clinical syndromes appear to differ. In most instances pituitary myxedema is the result of destructive lesions of the anterior lobe of the hypophysis, either from tumors or infarction. Usually it is complicated by loss of adrenocorticotropic and gonadotropic hormone secretions. From a,unctional standpoint, it is often difficult to determine whether or not complete destruction of the pituitary has occurred. Furthermore, the rapidity of alteration of thyroid function following ablation of all functioning anterior pituitary tissue, and the sequential relationship to the development of clinical hypothyroidism have not been clarified. This report deals with the effect of surgical hypophysectomy in 35 cases of metastatic cancer, both on the clinical status of...