Case Of Mature Cystic Teratoma Research Articles

A Rare Case of Mature Cystic Teratoma with Infantile Hemangioma and Pericardial Invasion

A Rare Case of Mature Cystic Teratoma with Infantile Hemangioma and Pericardial Invasion

Exploring the role of SOX 2 and OCT 4 in the pathogenesis of gliomatosis peritonei: the clinicopathological profile of eleven cases.

Gliomatosis peritonei (GP) is a rare entity characterized by multiple mature glial tissue implants in association with ovarian teratomas in the peritoneum and omentum. To date, only 100 cases have been published. Not much is known about the origin, clinicopathological profile or prognosis of GP. SOX2 and OCT4 are recently recognized markers of embryonic stem cell differentiation. Here, the role of SOX2 and OCT4 in the pathogenesis of 11 cases of GP are reported and clinicopathological factors are described. This was a retrospective study of six years duration (2017-2022). All the cases of GP were retrieved from archives, the diagnosis was confirmed and clinicopathological factors were noted. Immunohistochemical (IHC) investigation for glial fibrillary acid protein (GFAP) and S100 was noted wherever available. IHC for SOX2 and OCT4 was performed using an avidin-biotin technique. There were 11 cases of GP identified. The median age was 29 years and 1/11 cases had nodal gliomatosis as well. There were eight cases of immature teratoma and three cases of mature cystic teratoma. SOX2 was positive in all foci of GP, while OCT4 was negative. These foci were also positive for GFAP and S100. A possibility of GP should be considered as a differential, clinically and radiologically, in cases of omental nodularity. Adequate sampling at the time of surgery is essential to rule out metastasis or growing teratoma syndrome. SOX2, a stem cell marker inducing neural differentiation, may play a crucial role in the development of GP in association with other transcription factors.

Unusual Clinicopathological Presentations of Mature Cystic Teratoma: A case series

Mature cystic teratomas also known as dermoid cyst are one of the most common benign tumors of the ovary.It is usually seen in young women in the reproductive age group. It comprises of mature elements derived fromall the three germ layers. In this case series we reported a series of 4 cases of mature cystic teratoma of the ovarywith uncommon clinicopathological presentations. First case was a rare entity of melanocytic nevus arising froma mature cystic teratoma. Second case was adipocyte rich teratoma, an uncommon lipomatous lesion of the ovary.Third case was rupture of dermoid cyst presenting as acute abdomen. Fourth case was mature cystic teratoma ina post-menopausal woman. To conclude, though dermoid cysts after surgical removal have an uneventful clinicalcourse, extensive sampling of the specimen for histopathological study should be done to identify rare pathologieswhich bears a clinical significance.

A Rare Case of Mature Cystic Teratoma of Spinal Cord

Intraspinal teratomas are uncommon tumors that arise from embryonic germ cells and can contain elements from all three germ layers. They are usually located in the dorsal or ventral aspect of the spinal cord, and may be associated with spinal dysraphism or other congenital anomalies. MRI is a valuable tool for the diagnosis and characterization of these tumors, as it can demonstrate their location, extent, and composition. We report a rare case of an intramedullary teratoma in a 54-year-old male who presented with progressive paraparesis and sensory loss. MRI revealed a large, heterogeneous intensity solid cystic mass occupying the spinal cord at L1 to L2 vertebral level with cystic and solid components, fat and calcification. The tumor was surgically removed and confirmed to be a mature teratoma by histopathology. The patient had a good postoperative recovery and no recurrence at 6 months follow-up. This case illustrates the MRI features and surgical management of a rare and challenging spinal tumor.

A Rare Case of Mature Cystic Teratoma of Mediastinum

We report a rare case of a 24-year-old asthmatic male who presented with an episode of hemoptysis. Initial evaluation with chest X-ray showed a mass in the left hemithorax. Computed tomography of the chest showed a heterogeneous, encapsulated mass in the anterior mediastinum. The patient subsequently underwent surgical en bloc resection of the tumor and on histopathological examination, it was found to be a benign mature cystic teratoma (MCT). Radiological and pathological evaluation helps in the confirmation of the diagnosis. MCT has an excellent prognosis after surgical resection.

Mature cystic teratoma of spinal cord in an adult

Aim: Reporting a rare case of mature cystic teratoma of spinal cord in an adult
 Background: Teratomas of the central nervous system are rare lesions accounting for less than 0.5-2% of all CNS tumors. Most of these are found in pediatric age group and favor sellar - suprasellar, pineal and sacro-coccygeal regions. Their occurrence in spinal cord in an adult is incredibly rare.
 Case presentation: A 22-year-old male presented with low back ache and weakness of both lower limbs. Clinical examination and radiological workup revealed presence of a cystic lesion causing diffuse enlargement of the cord from L1 to L5-S1. Histo-pathological examination of the excised lesion revealed it to be teratoma.
 Conclusion and clinical significance: Mature teratoma of the spinal cord in adults is extremely rare occurrence. However, this diagnosis should be kept in mind when evaluating a cystic lesion of cord even in adults. Maximal safe resection of the lesion results in prolonged deficit-free survival.

Pilocytic Astrocytoma Arising in Ovarian Mature Cystic Teratoma: An Unusual Neuroectodermal Malignant Transformation Occurring in Pregnant Female

Mature cystic teratomas are usually benign, however malignant transformation occurs rarely. It is identified in only 0.17-2% of cases. Malignant cells can arise from cell of any type, but most common malignant transformation found to be squamous cell carcinoma (80% cases) followed by adenocarcinoma. While neural tissue is identified in nearly 80% cases of mature cystic teratomas, neuroectodermal tissue with malignant transformation is the most exceptional event. There is minimal data available on primary neuroectodermal tumours of ovary, majority are astrocytoma of different grades, only few cases were reported in the literature so far. Authors report a extremely rare and unique case of pilocytic astrocytoma arising from a mature cystic teratoma in a pregnant female. A 33-year-old pregnant female in her first trimester came for regular antenatal visit, Ultrasound (USG) abdomen and pelvis single live intrauterine gestation corresponding to 10 weeks and incidental complex right ovarian cyst likely to be mature cystic teratoma. Patient underwent right ovarian cystectomy five months after normal vaginal delivery and provisional diagnosis was given as complex right ovarian dermoid cyst. Final detailed histopathological examination revealed a tumour with glial tissue within the cyst, reported as pilocytic astrocytoma {World Health Organization (WHO) grade 1} arising in mature cystic teratoma. To the best of authors’ knowledge this is the third case showing pilocytic astrocytoma component in ovarian teratoma and the first case of this entity occurring in a pregnant female. Authors present an unusual case where radiology gave preliminary diagnosis however, extensive histopathological examination, histochemistry and immunohistochemistry helped in definite diagnosis.

Malignant Transformation in a Mature Cystic Teratoma of the Ovary: A 5-year Descriptive Study.

Malignant transformation (MT) in mature cystic teratoma of the ovary (MCTO) is rare. This descriptive study primarily aims to determine the prevalence rate of MT in MCTO and describe clinicopathologic features, management, and prognosis of patients who developed this rare type of tumor and likewise deliver a review in the light of recent literature. This is a descriptive observational study of 22 patients with MT in MCTO at a Level 3 Tertiary Public Hospital in Baguio City, Philippines. The clinical and pathological records of each patient were reviewed. Descriptive statistics were used. Between January 2016 to December 2020, of the 369 cases of mature cystic teratoma, 22 cases with malignant transformation were reported with an incidence of 6%. The mean age of diagnosis was 52 years, of which 70% are aged 50 years old and above. Fifty-nine percent (13/22) and 32% (7/22) of the cases were squamous cell carcinoma and mucinous adenocarcinoma, respectively. Very rarely, malignant transformations were carcinoid tumors (1) and follicular carcinoma (1). The most common reason for consult among patients is a palpable abdominal/pelvic mass (45.5%). Around 60% percent of cases have an elevated CA-125 value with a mean level of 180 U/ml. Seventy-two percent of cases with malignant transformation measured 10 cm or more with the largest mean diameter of 13 cm. Five patients underwent fertility-sparing surgery. Fourteen had staging procedures. Twelve patients were at Stage I. Three were at Stage II. Four and three patients were at Stage III and IV, respectively. Ten patients received adjuvant platinum-based chemotherapy and nine patients warrant no treatment after surgery. The median survival time is 14 months. Although not common, malignant transformation in MCT should be considered in older patients with large tumor sizes and elevated CA-125 assessed as MCT in preoperative and intraoperative assessment. This ovarian malignancy suggests an aggressive behavior but complete resection with systematic staging and indicated adjuvant platinum-based chemotherapy may improve survival.

Benign Ovarian Cystectomies in Children and Adolescents: A Comparison of Transumbilical Single-Port and Multi-Port Laparoscopic Surgery

<h3>Study Objective</h3> To investigate the safety and clinical value of transumbilical single-port laparoscopic surgery (TSPLS) in the treatment of benign ovarian cysts in children and adolescents. <h3>Design</h3> A retrospective analysis was performed on 85 children and adolescents who underwent benign ovarian cystectomies in Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University from January 2019 to January 2022, including 55 cases of mature cystic teratoma, 16 cases of myxoid cystadenoma, 9 cases of serous cystadenoma, 2 cases of parovarium cyst, 2 cases of follicular cyst, and 1 cases of ovarian thecoma-fibroma. Among them, 33 cases with transumbilical single-port laparoscopic oophorocystectomy (TSPLO group), median age was 14 years (7-18 years), mean diameter of ovarian cysts was (13.06 ± 7.80 cm). 52 cases with transumbilical multi-port laparoscopic oophorocystectomy (TMPLO group), median age was 15 years (6-18 years) and mean diameter of ovarian cysts was (7.69 ± 2.80 cm). Operative time, intraoperative blood loss, intraoperative cyst rupture rate, time to anal exhaust and hospital stay, Cosmetic Score (CS) and Visual Analogue Scale (VAS) were compared between the two groups. <h3>Setting</h3> N/A <h3>Patients or Participants</h3> N/A <h3>Interventions</h3> N/A <h3>Measurements and Main Results</h3> No conversion to laparotomy or surgical complications occurred in the two groups, and no statistical significance in operative time, intraoperative blood loss and intraoperative cyst rupture rate (all P > 0.05). The time to anal exhaust (18.82 ± 4.58 h vs. 21.29 ± 5.11 h, P = 0.027) and hospital stay (3.39 ± 0.83 day vs.3.92 ± 1.13-day, P = 0.023) in TSPLO group were shorter than those in TMPLO group. Lower postoperative VAS scores and higher CS scores were seen in the TSPLO group (all P < 0.05). <h3>Conclusion</h3> TSPLS is safe and feasible for benign ovarian cysts in children and adolescents, and has obvious advantages of fast postoperative recovery, good cosmetic effect and high satisfaction rate of patients.

Complete small bowel with a dysplastic foci in mature cystic teratoma of the ovary: Case report

Introduction: Mature cystic teratomas otherwise called dermoid cysts, are the most common ovarian tumors and account for a vast majority of germ cell tumours with highest incidence in women of reproductive age group. They contain elements originating from all three embryonic germ cell layers.Case report: A 14 years old female presented with complaints of abdominal pain and vomiting since 1 week. On further investigations, USG showed features suggestive of dermoid cyst-right ovary. Right sided oophorectomy was performed and the specimen was sent for histopathological examination. Grossly, the specimen showed multi loculated cyst filled with pultaceous material and tuft of hair. Microscopy showed fibro-collagenous cyst wall lined by stratified squamous epithelium containing adnexal structures and complete small intestine composed of all four layers of mucosa, sub mucosa, muscular is propria and serosa. Foci of well-formed mucosa showing mild dysplastic changes was also noted.Conclusion: Mature cystic teratoma of the ovary frequently contains intestinal-type tissues, but these rarely organize into complete intestinal wall with all layers. We hereby report a case of mature cystic teratoma with a rare presentation of complete small intestinal structure showing mild dysplastic changes.

A Case of Mature Cystic Teratoma of the Mesentery

A Case of Mature Cystic Teratoma of the Mesentery

A case of mature cystic teratoma of the fallopian tube treated using laparoscopic surgery

A case of mature cystic teratoma of the fallopian tube treated using laparoscopic surgery

Cystic Lesions of Anterior Mediastinum: Case Report

Abstract Cystic lesions of the mediastinum are uncommon, comprising 12% to 18% of all primary mediastinal tumors and unless they attain a large size and cause compressive symptoms, these tumors are generally asymptomatic and are discovered incidentally upon radiologic investigation of some other condition. We present in this paper a case of cystic lesions of the mediastinum in a 70-year-old male patient who underwent a surgery for mediastinal mass removal. Histopathology report had shown it was the case of mature cystic teratoma of anterior mediastinum. Based on a review of the literature, as well as our experience, we conclude that best treatment for cystic lesions of anterior mediastinum is complete surgical resection if possible.

Mature Cystic Teratoma of the Suprasternal Fossa in an Adult: Report of Case

Teratomas have been reported to occur in multiple organ regions, and are less common in non-gonadal regions, such as the neck and chest, than in gonadal and midline regions of the body, such as ovaries and testis. Cases have been reported of a large teratoma of the anterior mediastinum extending to the neck, causing symptoms such as dyspnea, which can be quickly detected by Ultrasound, and patients can be quickly treated. In adults, primary teratoma at the suprasternal foss that not accumulate thyroid gland upward and not invade the mediastinum are rare, usually have no obvious clinical symptoms and are found in most patients by chance. In this literature, we report a rare case of mature cystic teratoma in the suprasternal fossa of a 33-year-old male. Preoperative ultrasonography showed a superior sternal fossa tumor with less calcification and more adipose tissue. The final pathologic diagnosis was mature cystic teratoma through open surgery of the suprasternal neck incision. The patient was followed up for 9 months and there was no recurrence. We believe that the suprasternal notch approach is a safe and effective method for the treatment of mature teratoma without protruding into the superior mediastinum.

Mature cystic teratoma of the uterus presenting as an endometrial polyp in a patient with a history of ovarian mature cystic teratoma with gliomatosis peritonei and ovarian endometriosis: a case report

Teratomas of the uterus are rare neoplasms and are usually polypous lesions that present clinically as abnormal uterine bleeding. Gliomatosis peritonei (GP) is characterized by peritoneal implants of non-neuronal glial tissue and is a rarely-encountered complication of ovarian teratomas. To the best of our knowledge, mature cystic teratoma of the uterus as well as ovarian teratoma with GP and ovarian endometriosis are rare phenomena. Here, we report a case of mature cystic teratoma of the uterus presenting as an endometrial polyp in a patient with a history of ovarian teratoma with GP and ovarian endometriosis.

Histological spectrum, bilaterality, and clinical evaluation of ovarian lesions – A 10-year study in a rural tertiary hospital of India

BACKGROUND: Ovarian malignancy is the second most common cancer of the female reproductive system and the leading cause of death from gynecologic malignancy. Study on the distribution of the different ovarian neoplasms is limited from Eastern India, especially in rural areas. AIMS AND OBJECTIVES: The aim was to study the distribution of morphological pattern of benign, malignant, and nonneoplastic lesions of the ovary in different age groups and to determine the likelihood of bilateral involvement in different morphologic subtypes. MATERIALS AND METHODS: A retrospective study from January 2009 to December 2018 was undertaken. A total of 2100 surgical specimens were obtained. Detailed clinical information and radiological findings were recorded from the case sheets. Grossing of the surgical specimens was done in the pathology department, followed by histological examination. RESULTS: Of 2100 cases, benign cases were 1491 (71%), malignant cases were 252 (12%), and nonneoplastic were 357 (17%). The distribution of malignant cases was 10–19 years (18 cases, 7.14%), 20–29 years (50 cases, 19.84%), 30–39 years (23 cases, 9.13%), 40–49 years (61 cases, 24.20%), 50–59 years (70 cases, 27.78%), and 60–69 years (30 cases, 11.91%). Among the benign cases, serous cystadenoma was 684 cases (32.57%), followed by mucinous cystadenoma cases (330, 15.71%) and mature cystic teratoma cases (270, 12.86%). Among the malignant cases, bilateral serous cystadenocarcinomas were found in 42.85% of the cases, and among benign cases, bilateral endometrioid tumors were found in 27.58% of the cases, and among nonneoplastic diseases, bilateral follicular cysts were found in 35.21% of the cases. CONCLUSION: In this study, an earlier presentation of malignant tumors was observed. Furthermore, a lower percentage of serous cystadenocarcinoma was noted compared to other studies.

Collision Tumors in Ovary: Case Series and Literature Review

Histologically distinct tumors that coexist in an organ without any histological admixture at their interface are denominated collision tumors. We report 3 cases of colliding mature cystic teratoma with mucinous cystadenoma and a case of mature cystic teratoma colliding with benign Brenner tumor in the ovary. We also provide a literature review based on 35 previously published ovarian collision cases. Ovarian tumors from all classes, benign, borderline and malignant lesions may collide. Both our case series and the literature review indicate that ovarian tumor collisions tend to be clinically and ultrasonographically/radiologically unrecognized. The awareness among surgeons, radiologists and pathologists of this rare phenomenon and histological recognition are crucial in order to offer adequate treatment to patients. There is a need to identify novel and more specific imaging clues pointing towards collision tumors in the ovary.

Effects of mature cystic teratoma on reproductive health and malignant transformation: A retrospective analysis of 80 cases

Objective:To examine cases of mature cystic teratoma (MCT) that were diagnosed and treated in our clinic regarding their association with fertility, and to detect the rate of malignant degeneration and the types of malignancies.Material and Methods:Patients who underwent surgery due to adnexal mass between April 2012 and August 2017 and were diagnosed as having MCT were retrospectively examined. The mean age of the 80 patients who met the inclusion criteria was 30.60±10.5 years. Nine had infertility according to hospital records. Sixty-seven percent of these (n=6) had accompanying endometriosis and MCT was bilateral in 55.5% (n=5). Malignant degeneration was present in 6.25% (n=5), all were monodermal tumors. Malignant degeneration was more common among patients with larger diameter adnexal masses (9.1±2.9 cm) and in those of postmenopausal age. Tumor markers were within the normal range for patients who developed malignancy. Malignant degeneration was not present among infertile patients with endometriosis.Results:Although MCTs do not seem to negatively affect the ovarian reserve, infertility is prominent in patients with concurrent endometriosis. During assessment, concurrent endometriosis should be considered. Imaging findings, large adnexal masses, and postmenopausal period are important for the assessment of MCT concerning malignant degeneration. It should not be overlooked because tumor markers may be normal.Conclusion:MCTs can be present concurrent with endometriomas. In such cases, infertility is more distinct. In MCT malignant degeneration, mass diameter, complex mass internal structure, and postmenopausal status are important factors.

A Case of Mature Cystic Teratoma Covered with the Greater Omentum and Suspected Deriving from the Ovary

A Case of Mature Cystic Teratoma Covered with the Greater Omentum and Suspected Deriving from the Ovary

Colonic mature cystic teratoma

Abstract Aim of the study We would like to report an unusual case of mature cystic teratoma (MCT) of the left colon presenting with intestinal obstruction in a syndromic patient with low-anorectal malformation (ARM). Case report The boy had multiple malformations: low ARM with perineal fistula, situs ambiguous, dextrocardia, double outlet right ventricle with pulmonary stenosis and anterior aorta. At two years he required cardiac surgery but he developed intestinal obstruction. The intestinal condition put us in a diagnostic challenge: we thought about intestinal stenosis with fecal impaction but radiological investigations were inconclusive. During surgery we identified an abdominal mass that was resected together with the adjacent descending colon. Histology showed MCT. Follow-up was uneventful. Conclusions MCT rarely occurs outside the sacrococcygeal–gonadal location. They are frequently associated with ARM in Currarino Syndrome: the mass is located in front of the sacrum and causes anal stenosis. Nevertheless, in the reported patient, MCT did not arise from the spine but from the left colon. Paediatric cases of colonic MCT have never been reported. Affected adults can develop constipation and/or intestinal obstruction. Surgery permits to remove the mass in both symptomatic and asymptomatic patients.