Case Of Malignant Mixed Tumor Research Articles

Clinical application of endoscopy-assisted resection of tumors in parapharyngeal space

To explore the advancement of the endoscopic video system in parapharyngeal space tumor resection. Thirty cases parapharyngeal space tumor patients underwent endoscopy-assisted tumors resection in otorhinolaryngology-head and neck surgery of Tianjin First Central Hospital. The passway included trans-oral cavity in 6 cases, 21 cases with trans-neck side and trans-neck-parotid gland in 3 cases. Tumors of all cases were completely resected, without residual tumor. It was included 23 cases of benign tumors (14 cases of parotid pleomorphic adenoma, 8 cases of neurilemmoma, lymph node tuberculosis in 1 case), malignant tumor in 7 cases (2 cases of metastatic carcinoma, 2 cases of malignant mixed tumor, 1 case of malignant neurilemmoma, 2 cases of adenoid cystic carcinoma). Tongue deflection was recorded in 2 cases. There were neither wound infection or bleeding. All the cases were followed up after operation without recurrence. Seven cases of malignant tumor patients were all alive with follow-up 1 year in 1 case, 3 years in 4 cases, 2 cases for five years. Endoscopy-assisted tumors resection can deal with visual lesion corner and allow previous part no visibility surgery into all operation under direct vision. It contributed to improve the quality of operation, reduce the surgery complication. It was worth to be wide spreaded in clinic.

Epithelial lacrimal gland tumors: A comprehensive clinicopathologic review of 26 lesions with radiologic correlation

AimTo study the prevalence, clinicopathological and radiological correlations of epithelial lacrimal gland tumors and compare these with similar published literature. The study was also designed to look at the natural history of benign mixed tumors (BMT) in regard to recurrence and malignant degeneration. MethodsThis was a retrospective study of all suspected epithelial tumors of the lacrimal gland surgically excised at King Khaled Eye Specialist Hospital (KKESH) for the period: 1983–2008. Exclusion criteria included structural lesions (dacryops) and inflammatory lesions. We included 26 cases of epithelial lacrimal gland tumors (from 24 patients). The histopathologic slides and the radiologic findings were reviewed. The corresponding demographic and clinical data were obtained by chart review using a data sheet. ResultsBMT accounted for 12/26 of the lesions while malignant lesions including adenoid cystic carcinoma (ACC) were more common (14/26). The mean age was 44.27years (range 12–75). Commonest clinical presentation was proptosis. Median duration of symptoms in the BMT cases was 30months and 7months in the ACC group. The 12 BMT cases were primary in 9 and recurrent in 3 patients. The 11 ACC cases showed mostly cribriform pattern and low histopathologic grade. We had 2 cases of malignant mixed tumor (MMT) one of which arising in a recurrent tumor. One case of primary mucoepidermoid carcinoma with histopathologic grade 2 was noted. Radiologically, a well-defined appearance with bone remodeling was observed in BMT in contrast to invasive appearance with destruction in malignant lesions. ConclusionOur series information indicated a different distribution of benign and malignant epithelial lesions with a slightly higher rate of malignancy. BMT was the commonest benign tumor where recurrence was a squeal of incomplete surgical excision. ACC was the commonest malignant tumor with shorter duration of symptoms and radiologic evidence of invasiveness that correlated with the histopathologic features.

Malignant myoepithelial tumor of soft tissue: a report of two cases of the lower extremity and a review of the literature

Myoepithelial tumors of the soft tissues have only recently been described. Two cases of lower extremity malignant myoepithelial tumors are reported. One case of malignant mixed tumor overlying the gastrocnemius muscle was treated with wide local excision, but metastasized to regional lymph nodes 14 months after surgical excision. One patient with malignant myoepithelioma of the right lower leg was treated with limb amputation and is alive without disease at 46 months. A review of the literature discloses 120 additional cases of soft tissue myoepithelial tumors, 102 of which are myoepitheliomas and 18 are mixed tumors. Thirty-seven percent of the myoepitheliomas met the criteria for malignancy, and 33% of the mixed tumors were malignant. Of these, 30% had locally recurrent disease and 32% developed metastatic disease. Treatment benefit from chemotherapy and radiation therapy is unclear.

Salivary Gland-Type Tumors With Myoepithelial Differentiation Arising in Pulmonary Hamartoma

Reported is a hitherto unrecognized association of pulmonary hamartomas with salivary gland-type tumors showing myoepithelial differentiation, namely, a case of myoepithelioma arising in a otherwise classic hamartoma with cartilage predominance, and a case of malignant mixed tumor arising in a predominantly fibrous hamartoma resembling müllerian adenofibroma. The tumors occurred in middle-aged female patients of 35 and 44 years, respectively, and presented as 7 cm (treated with lobectomy) and 13 cm (treated with pneumonectomy) masses of the right upper lobe showing a short clinical history of cough, dyspnea, and wheezing. Both lesions did not present regional lymph node metastases after mediastinal lymphadenectomy. The myoepithelioma patient was well with no signs of recurrent disease at 6-month clinical control, but she was then lost to follow-up; the malignant mixed tumor patient is alive and well after 6 months since operation. Both tumors presented with morphologic and immunohistochemical features of myoepithelial cells, and we interpret them as being derived from a myoepithelial-like stromal cell population found within the hamartomatous areas, which is also consistently detected in classic pulmonary hamartoma. The lack of individual cell necrosis, mitotic activity, cell atypia, and pulmonary parenchyma infiltration supported a diagnosis of benign or unproven malignant potential tumor for the myoepithelioma, whereas the reverse held true for the other tumor in which the diagnosis of malignant mixed tumor of the lung was rendered. Their main importance of recognizing this association lies in separating these tumors histologically from other monophasic or biphasic tumors, either primary or secondary, such as pulmonary sarcomatoid carcinomas or true sarcomas, and metastatic salivary gland tumors, spindle cell carcinomas, melanomas, and soft tissue and visceral sarcomas.

Prognostic factors in malignant mixed tumors of the salivary gland: correlation of immunohistochemical markers with histologic classification.

Malignant mixed tumor of salivary glands is a rare tumor whose variable behavior and prognosis are related for the most part to the clinical stage and histologic grade of the carcinomatous component. The purpose of this study is to predict prognosis by comparing the histologic grading and subclassification of the carcinomatous component with the immunohistochemical reactivity for E-cadherin, P53 mutation protein, and cellular proliferation (Ki67). Stains were performed on formalin-fixed paraffin-embedded tissue sections from 18 cases of malignant mixed tumor. Clinical follow-up was obtained for each patient. Regional lymph node and distant organ metastases were the criteria for poor prognosis. Of seven cases with lymph nodes metastasis, five were high-grade tumors (with one subsequent death from brain metastasis) and two were low-grade. Of the eight high-grade tumors, positivity for Ki67, p53, and E-cadherin were noted in six, four, and two cases, respectively. In contrast, of the 10 low-grade tumors, two stained with Ki67, five with p53, and none with E-cadherin. Most notably, all seven metastatic cases (as opposed to only one of 11 nonmetastatic tumors) had Ki67 reactivity of more than 10%. We conclude that malignant mixed tumor represents a spectrum of malignancies in which the clinical behavior is closely related to the carcinomatous element. In addition to histologic grading, Ki67 is a useful prognostic marker in the evaluation of malignant mixed tumor while p53 and E-cadherin appear to be of limited value.

The Pathologic Picture and Immunohistochemical Study Of Carcinoma In Pleomorphic Adenoma

Objective 1. To solve mixed tumor with cell activated growth, so called"semi\|malignant".malignant and the difference with subtype.2.measure the pathologic picture of pleomorphic adenoma and its combinated index with cell proliferation activity and oncogene, deepen the knowledge of biological behavior.Methods select 36 cases of mixed tumor with cell growth active and 9 cases of malignant mixed tumor and 16 cases of invasive carinoma, to slice up continuously, and stain with specific and immuohistochemistry,and review clinical data.Results the expression of AgNORs. Ki\|67. PCNA.VEGF and p53 are positive, and the p53 is strong positive in area of malignant mixed tumor, but the expression of tissue adjacent tumor is skeptical positive or negative.Conclusion through the detection of pathologic picture and cell proliferation activity of carcinoma in pleomorphic adenoma, first put forward the diagnosis criteria of carcinoma in situ.invasive carcinoma and malignant mixed tumor.

Malignant mixed tumor of the skin (malignant chondroid syringoma)

Two cases of malignant mixed tumor of skin were studied, one of which demonstrated regional metastasis. The immunohistochemical features of these 2 neoplasms and of the 2 malignant mixed tumors previously described in Western Australia indicate that these neoplasms show eccrine differentiation and suggest their origin from both the secretory and ductal segments of the gland. The histological criteria of malignancy are discussed, with particular reference to those features which indicate malignant potential in neoplasms which otherwise lack overt morphological criteria of malignancy.

Ultrastructural and immunohistochemical aspects of carcinoma in mixed tumors

Four cases of malignant mixed tumor (carcinoma in pleomorphic adenomas) were studied for ultrastructural appearance and for the presence of cytokeratins and vimentin. Ultrastructurally, both squamous and glandular epithelial differentiation were found not only in the same tumor but also within the same cell. One tumor showed mainly mesenchymal differentiation with fibroblast-like cells. The intermediate filament expression of benign mixed tumors (i.e., both cytokeratin and vimentin content) were found in two of the three malignant tumors investigated. In the third tumor, only cytokeratins were found. Thus, the filament content of mixed tumors may change when the tumor becomes malignant. This change does not always parallel a change in morphology. Although one tumor was clearly epithelial ultrastructurally and another mostly mesenchymal, both did contain both cytokeratins and vimentin.

Primary Malignant Mixed Tumors of the Lacrimal Gland: Report of 10 Cases

Ten consecutive cases of malignant mixed tumor (pleomorphic adenocarcinoma) primary in the lacrimal gland were studied for clinical features, pathology, course and prognosis, and surgical management. Long-term follow-up data were available on all patients and emphasized the malignant nature of the neoplasm. Survival intervals after the initial operation varied and seemed dependent on whether the neoplasm was initially histologically malignant or became malignant during the recurrence of a benign mixed tumor. An en bloc, one-stage removal of neoplasm with attached periorbita and underlying bone is recommended to minimize early dissemination via bone.

Malignant mixed tumors arising in salivary glands.I. Carcinomas arising in benign mixed tumors: A clinicopathologic study

Forty-seven cases of malignant mixed tumor (MMT) arising in major and minor salivary glands are presented. By definition, all these lesions contained both a benign mixed tumor (BMT) as well as a malignant neoplasm, usually a poorly differentiated carcinoma. In some cases, the carcinoma developed in a previously untreated salivary gland mass which was known to have been present for many years, others evolved in a recurrent previously resected BMT and still others originated in a previously undetected BMT. Adverse prognostic factors included: carcinomatous involvement of the resection lines, perineural invasion, metastases in lymph nodes, and origin in a major salivary gland. Lesions arising in the palate had a better prognosis as compared to major salivary gland tumors. Some patients died of locally uncontrollable tumor and others because of metastatic disease. Local recurrences of MMT were seen frequently; 18 patients (38%) had a total of 32 local recurrences. Of patients followed five years or more, seven (35%) had died of tumor, 11 (55%) had no evidence of disease, and two (10%) had died of other causes. Prolonged follow-up is required because recurrences and death from tumor may be seen many years following the diagnosis of MMT. Recommendations for therapy are made. Criteria for differentiating MMT from recurrent BMT and from cylindromatous carcinoma are discussed.

Malignant mixed tumor of parotid gland

A case of malignant mixed tumor of the parotid gland with metastases to multiple bones is reported. The mixed character of the tumor was most prominent in the well differentiated, benign appearing femoral metastasis while the primary tumor and local recurrence were predominantly adenomyoepitheliomatous with sparse but well defined myxochondroid components.