Abstract
Objective 1. To solve mixed tumor with cell activated growth, so called"semi\|malignant".malignant and the difference with subtype.2.measure the pathologic picture of pleomorphic adenoma and its combinated index with cell proliferation activity and oncogene, deepen the knowledge of biological behavior.Methods select 36 cases of mixed tumor with cell growth active and 9 cases of malignant mixed tumor and 16 cases of invasive carinoma, to slice up continuously, and stain with specific and immuohistochemistry,and review clinical data.Results the expression of AgNORs. Ki\|67. PCNA.VEGF and p53 are positive, and the p53 is strong positive in area of malignant mixed tumor, but the expression of tissue adjacent tumor is skeptical positive or negative.Conclusion through the detection of pathologic picture and cell proliferation activity of carcinoma in pleomorphic adenoma, first put forward the diagnosis criteria of carcinoma in situ.invasive carcinoma and malignant mixed tumor.
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