Case Of Intra-abdominal Bleeding Research Articles

Two Cases of Intraabdominal Bleeding Caused by Hepatocellular Carcinoma Rupture Soon after the Initiation of Chemotherapy with Lenvatinib

We herein report two patients with hepatocellular carcinoma (HCC) who exhibited intraabdominal bleeding caused by tumor rupture soon after lenvatinib initiation. A hypervascular nodule was present in the lateral segment manifesting extrahepatic protrusion in an 81-year-old-man and in the caudate lobe, which was completely occupied by the tumor, in an 83-year-old-man. Both patients were given lenvatinib, and epigastralgia occurred suddenly three and five days later. Computed tomography revealed high-attenuation areas suggesting bleeding around the left and caudate lobes. Considering the strong antiangiogenic effects by lenvatinib, transcatheter arterial embolization should be performed before lenvatinib initiation in patients with subcapsular HCC.

Prospective Randomized Controlled Study to Compare the Outcome of Standard 4-Port Laparoscopic Cholecystectomy with Single-Incision Laparoscopic Cholecystectomy in Patients with Gallstone Disease

Four-port laparoscopic cholecystectomy (LC) is the gold standard treatment for symptomatic gallbladder disease. To reduce the invasiveness of standard four-port laparoscopic cholecystectomy, single-incision laparoscopic cholecystectomy (SILC) has come about an attractive option for the performance of laparoscopic cholecystectomy. There have been no studies on SILC from Indian subcontinent. The present study was designed to compare the outcomes of SILC with the standard four-port LC in a prospective randomized controlled trial. All patients with symptomatic gallstone disease were evaluated between May 2012 and April 2014. Patients were randomized to either standard four-port laparoscopic cholecystectomy (LC group) or single-incision laparoscopic cholecystectomy (SILC group). Demographic profile, preoperative and intraoperative variables, postoperative complications, hospital stay, and pain scores were recorded. WHO-QOL BREF was used for quality of life analysis. Patients were followed up at regular intervals, and satisfaction scores were recorded. Statistical analysis was done using STATA 12 and p value < 0.05 was considered significant. Out of 94 patients, 90 received the intended treatment, and four cases in SILC group were converted to standard four-port cholecystectomy. The demographic profile and preoperative WHO-QOL BREF scores were comparable between the two groups. Severity of adhesions, successful dissection of Calot’s triangle, ergonomics, and overall level of difficulty were also comparable. Operation time was significantly higher in SILC group, but the learning curve was seen to be achieved after 30–35 cases. There was no significant difference in the incidence of immediate postoperative and chronic pain over a mean follow-up of 6 months except for pain score during normal activity in immediate postoperative period which was significantly higher in SILC group. Overall complication rate was significantly higher in SILC group, however the incidence of SSI was not found to be significant among the two groups. There was one case of transient bile leak and one case of intra-abdominal bleeding due to slippage of cystic artery clip. Postoperative quality of life outcomes were similar in the two groups. Although not significant, patients with SILC group had higher cosmetic score compared with the LC group. In conclusion, this study shows that SILC is a safe and feasible with a higher rate of complications but comparable cosmetic and QoL outcomes when compared with standard 4-port cholecystectomy.

A case of intra-abdominal bleeding with hemorrhagic shock by multiple trauma treated at a hybrid operating room

A case of intra-abdominal bleeding with hemorrhagic shock by multiple trauma treated at a hybrid operating room

Endometriosis as a Reason of Intraabdominal Bleeding in Pregnancy. Clinical Case

The article defines the significance and relevance of the problem of endometriosis during pregnancy. 10% of women in the reproductive period have different localization of endometriosis. 25% of pregnancies with endometriosis are complicated by preterm labor. The article presents a clinical case of intra-abdominal bleeding in a 28-year-old pregnant woman with retrocervical endometriosis at gestation age of 32 weeks and 6 days. The article covers the results of examination and special diagnostic procedures of intra-abdominal bleeding in pregnant women with retrocervical endometriosis. The main diagnostic methods were the study of past medical history, ultrasound examination, and laboratory tests. Due to their infrequency during pregnancy internal bleedings present difficulties in their diagnosis. Ultrasound reliably revealed a large amount of fluid in the abdominal cavity and small pelvis and excluded the presence of intrauterine bleeding. Clinical and laboratory tests indicated the severity of the patient's condition. Symptoms of moderate fetal distress were also identified. Therefore, a decision was made about an emergency delivery by the cesarean section followed by an abdominal revision. During the cesarean section, 500 ml of blood in the form of dark blood clots was found in the abdominal cavity. The condition of the premature newborn was in conformity with his gestational age. The source of bleeding were the of endometriosis on the back wall of the uterus. These focuses most likely caused hemoperitoneum. The revision of the abdominal cavity did not find any other foci of bleeding. The postoperative period was uneventful. The article provides general guidelines for the management of pregnant women with severe forms of endometriosis.

Single Purse-String Suture for Reinforcement of Duodenal Stump During Laparoscopic Radical Gastrectomy for Gastric Cancer.

Background: Duodenal stump leakage (DSL) is a serious surgical complication after radical gastrectomy with Roux-en-Y or BillrothII reconstruction. This study was designed to evaluate the effectiveness of laparoscopic single purse-string suture for reinforcement of duodenal stump.Methods: A total of 183 patients harboring gastric adenocarcinoma following laparoscopic radical gastrectomy with Roux-en-Y or BillrothIIreconstruction and single purse-string suture for reinforcement of duodenal stump were retrospectively enrolled from Zhongshan Hospital of Fudan University (Shanghai, China) between January 2014 and December 2016. Operative variables and short-term complications were documented and analyzed. Clavien-Dindo classification system was used to identify surgical complications.Results: Among 183 patients, 108 (59.02%) patients received distal gastrectomy and 75 (40.98%) received total gastrectomy. 88 (48.09%) patients underwent Roux-en-Y reconstruction and 95 (51.91%) patients underwent Billroth-II reconstruction. The mean time of laparoscopic single purse-string suture was 5.01 ± 1.33 min (range from 3.6 to 10.2 min). Postoperative early complication occurred in 26 cases of the patients. There were 4 cases of system-related complications (2.19%), including 3 cases of pulmonary infection (1.64%) and 1 cases of cardiovascular event (0.55%); and 22 cases of surgery-related complications (12.02%), including 6 cases of intra-abdominal infection (3.28%), 4 cases of pancreatic leakage (2.19%), 4 cases of wound complications (2.19%), 3 cases of gastroparesis (1.64%), 2 cases of intra-abdominal bleeding (1.09%), 2 cases of ileus (1.09%), 1 cases of lymphatic leakage (0.55%), and no duodenal stump leakage.Conclusion: Reinforcement on duodenal stump using laparoscopic single purse-string suture during laparoscopic radical gastrectomy is simple and effective and could avoid the incidence of duodenal stump leakage to some extent.

Safety and efficacy of spider anchoring device for apical repair in laparoscopic sacrocolpopexy: Retrospective cohort study

ObjectiveThe aim of the study was to assess safety and efficacy of apical support when using the soft-tissue metal fasteners of EndoFast Reliant™ SCP during laparoscopic sacrocolpopexy (LSCP). Study designThis is a single-center, retrospective cohort study including all patients which underwent LSCP between 2015 and 2017. Safety outcome included the procedure and the device related complications. Effectiveness outcomes included the anatomical success of apical repair and the functional results as were obtained from the clinic and from a Quality of life questionnaire (PFDI-20). ResultsEighty-four patients, 54% with grade III and IV prolapse were included in the study. Uterus was preserved in 68% of patients with uterus. Mean follow-up period for the clinic visit was 4.5 ± 4 months. Short term anatomical success was achieved for 98.8% of the patients. Marked improvement was observed in the related symptoms including urinary incontinence. Three intra-operative complications occurred: 1 case of bladder injury, 1 case of intra-abdominal bleeding, and 1 case of post-operative vaginal bleeding. Later complications included only two patients (2.3%) complained of chronic abdominal pain. There were no cases of mesh erosion or de-novo dyspareunia. The mean follow-up period for the PFDI-20 questionnaire was 15.6 months. 75% of patients had no bulge symptoms at all. Quarter of the patients had some bulge symptoms, bothers them between somewhat to moderately according to the questionnaire grading. ConclusionsThe use of Endofast SCP fasteners for laparoscopic promonto-fixation is a safe and effective surgery. Longer follow-up and larger studies should be performed to establish the results.

広範囲TAEで止血した胃全摘後の後上膵十二指腸動脈瘤破裂の1例

広範囲TAEで止血した胃全摘後の後上膵十二指腸動脈瘤破裂の1例

Totally laparoscopic total gastrectomy using the overlap method; early outcomes of 50 consecutive cases.

Construction of an esophagojejunostomy is still a challenging procedure in totally laparoscopic total gastrectomy (TLTG), and there is no standard anastomosing method. The aims of this study were to describe our TLTG with the overlap method using a linear stapler and report surgical outcomes. From January 2015 to April 2016, 50 patients underwent TLTG using the overlap method for gastric cancer. The procedures were performed by a single surgeon, and the patients' medical records were reviewed. Their clinicopathologic characteristics, operation time, date of flatus, hospital stay, morbidity, and mortality were analyzed. The median age and body mass index were 56years and 23.5, respectively. Stage 1A tumors were the most common. Mean operating time was 144.6min, and no cases required changing to open laparotomy during surgery. On average, flatus occurred 3.5days after surgery, and patients were discharged 6.8days after surgery. No patient experienced anastomosis leakage, stricture, duodenal stump leakage, luminal bleeding, pancreatic fistula, or wound problems. There were two cases of intra-abdominal bleeding that required additional surgery. Intra-abdominal fluid collection and mechanical ileus occurred in two patients, respectively, and were successfully managed with conservative treatment. We reported favorable surgical outcomes of TLTG using the overlap method. It is a feasible and safe option for treatment of gastric cancer.

異所性静脈瘤破裂による腹腔内出血の1例

異所性静脈瘤破裂による腹腔内出血の1例

鼠径部子宮内膜症を伴う鼠径ヘルニア術後の子宮円靱帯断裂腹腔内出血の1例

32歳女性，3年前から子宮内膜症にてホルモン療法．月経時の右鼠径部の違和感，圧痛を認め，子宮内膜症を合併したNuck管水腫疑いで2010年3月手術施行．右子宮円靱帯を通常どおりテーピング．ヘルニア嚢は内腔が腹腔内と交通しており，右外鼠径ヘルニアと診断．ヘルニア嚢内にヘモジデリンの沈着を認め，子宮内膜症の所見と考え，高位結紮，子宮円靱帯と伴にヘルニア嚢を切除した．術翌日，腹痛および貧血を認めた．CTにて腹腔内出血と診断，緊急腹腔鏡下止血術を施行した．骨盤に子宮内膜症による炎症，癒着を認めた．右子宮円靱帯が断裂し，出血源であった．バイポーラ電気メスおよびクリップで止血した．子宮円靱帯のテーピング牽引操作で，子宮内膜症の炎症により脆弱になった腹腔内の右子宮円靱帯が断裂，出血したと考えられた．子宮内膜症の患者では，鼠径ヘルニア手術の際，子宮円靱帯のテーピング牽引操作は愛護的に行う必要がある．

Laparoscopic Resection of Gastric Submucosal Tumors: Outcomes of 141 Consecutive Cases in a Single Center

Purpose: The treatment of choice for gastric submucosal tumors (SMT) is surgical resection. Recent advanced techniques has facilitated more extensive application of laparoscopic surgery to most types of resectable gastric SMTs. The aim of this study was to verify the efficacy of laparoscopic resection for treatment of gastric SMT through analysis of outcomes obtained at a single center. Methods: A total of 141 patients who underwent laparoscopic resection for treatment of gastric SMT were enrolled between April 2003 and June 2011. Analysis of the demographics, tumor characteristics, and surgical or oncological outcomes of these patients was performed. Results: Gastrointestinal stromal tumors (GIST) were the most common pathologic findings (90 cases), and the upper third of the stomach was the most common location (70 cases). Wedge resections were performed in 128 patients and major gastrectomies were performed in 13 patients. The mean surgical time was 102 minutes, which was reduced to a stable 70 minutes after the 30 th case. The surgical time for tumors located on the posterior or lesser portion of the upper third of the stomach was longer than that for other lesions. Twelve postoperative complications, including two cases of intra-abdominal bleeding, one case of marginal ulcer bleeding, and one case of leakage occurred. However, there was no occurrence of complications after the 70 th case. During the follow-up period, two patients suffered recurrent GIST. Conclusion: Laparoscopic surgery for treatment of gastric SMT is safe and feasible, particularly as the surgeon develops greater skill with increased experience. Laparoscopic resection is useful for treatment of any type of gastric SMT.

General complications following laparoscopic-assisted gastrectomy and analysis of techniques to manage them

The aim of this study was to assess the complications associated with the laparoscopic treatment of gastric cancer and to discuss their management. From March 2004 to June 2007, 302 patients affected by gastric adenocarcinoma underwent laparoscopy-assisted gastrectomy. Of the 302 gastric malignancy cases, distal gastrectomy was performed in 161 cases, proximal gastrectomy in 62 cases, and total gastrectomy in 79 cases. In all cases, D1 or D2 lymph node dissection was performed according to the recommended procedures of the Japanese Gastric Cancer Association. Duration of surgery ranged from 180 to 310 min (median 230 min). There were no deaths during surgery and no anesthesiology complications in our series. We recorded 15 (4.97%) intraoperative complications: one transverse colon perforation, one lesion of the liver, two cases of splenic laceration, one injury of cystic artery leading to gangrene of the gallbladder, nine cases of hemorrhage, and one biliary tract injury. Conversion to open surgery was necessary in only five cases (1.7%). We recorded 21 (7.0%) postoperative complications: four cases of intra-abdominal bleeding, seven cases of duodenal stump leakage, one case of duodenal stump leakage followed by arteriole hemorrhage due to fundus of the stomach, two cases of acute pancreatitis, one case of lymphatic fistula, one case of anastomotic fistula, three cases of delayed gastric emptying, and two cases of obstruction of afferent loop. Six patients underwent reoperation, of whom two died after the procedure while the other four recovered postoperatively; other postoperative complications were treated conservatively. The overall operative morbidity and mortality rates were 11.9% and 0.7%, respectively. Our results show that laparoscopic-assisted gastrectomy is an adequate treatment for gastric cancer as long as the indications are controlled and only suitable cases are enrolled in the series. The complication rate is low enough to be acceptable. Most complications can be treated effectively via conservative treatment, and only a small number of cases require reoperation.

Transvenous cholangiography and percutaneous transhepatic fine needle cholangiography (author's transl)

The comparison of transvenous cholangiography (TVC) in 82 patients with percutaneous transhepatic fine needle cholangiography (PTFC) in 84 patients showed that TVC must be considered obsolete due to the complicated procedure with low success rate (56.9%). In one case it led to septicaemia followed by death. The total success rate was 84.5% in PTFC performed with an ultrathin needle (0.5 mm diameter); congested biliary ducts were successfully punctured in 87.9% and noncongested ducts in 72.2%. Severe complications consisted of one case of intraabdominal bleeding and one biliary extravasation. As shown in animal experiments, the superficial parenchymal lesion has not always the shape of a point. High accuracy also in noncongested biliary tracts and low mortality make PTFC superior to TVC and conventional percutaneous transhepatic cholangiography.

The complications of percutaneous endoscopic gastrostomy

Percutaneous endoscopic gastrostomy (PEG) has become the primary procedure for the long-term nutrition of patients with swallowing disorders. It has been shown to be an effective method with a lower complication rate than surgical placement [1]. It can be performed in the intensive care unit, but complications may occasionally occur. The estimated incidence of major complications is 8% [2]. Abscess and wound infections are the most frequent complications, but necrotizing fasciitis, colon or small bowel injuries, gastrocolic fistula, duodenal hematoma, liver injury, gastric perforation, and catheter migration have also been described [3]. Unexpectedly, acute hemorrhage following PEG is rarely reported. In the literature, we found only one case report of a fatal retroperitoneal hemorrhage occurring 2 hours after a PEG [4]. In a series of 263 cases, Schurink and colleagues [2] described only two cases of intra-abdominal bleeding. A 59-year-old man was admitted to our hospital with intracerebral hemorrhage. On day 40, a PEG was performed in the intensive care unit using the 'pull' technique as previously described [5]. The needle puncture of the stomach was accomplished only on the second attempt, although the rest of the procedure was completed uneventfully. The material used was the Bard®Fastrac™ Pull PEG Kit (Bard Access Systems, Salt Lake City, USA). One hour after the end of the procedure, the patient presented a tachycardia (120 beats per minute), with cardiovascular collapse (arterial pressure 70/50 mmHg). Physical examination revealed a distended abdomen. The hemoglobin concentration was 5.5 g/dL. Abdominal echography showed the presence of intraperitonal liquid. An emergency laparotomy was performed, revealing a massive hemoperitoneum due to active bleeding from a small vessel of the minor curvature. X-sutures were applied and the bleeding stopped. A gastrostomy was recreated at the end of surgery. The massive hemoperitoneum we described is a rare complication in relation to its rapidity and its severity. We think that the initial, unsuccessful passage of the needle could have caused the gastric artery branch laceration. Indeed, such a mechanism of injuries has already been suggested as an explanation for a fatal retroperitoneum due to breaches in the splenic and superior mesenteric veins [4]. In the patient we described, prompt recognition could minimize morbidity. Although generally considered safe, PEG can be associated with life-threatening bleeding, especially when multiple needle punctures have been made. It presents with unexplained postprocedure hypotension. Intensivists who are used to performing PEG should be aware of this complication because early recognition and treatment are essential.

Perioperative and post-operative complications of transvaginal ultrasound-guided oocyte retrieval: prospective study of &gt;1000 oocyte retrievals

Although transvaginal ultrasound-guided oocyte retrievals (OR) are performed routinely worldwide, there is very little systematic data about its complications. We performed a prospective cohort study following the perioperative and post-operative complications of over 1058 ORs. Additionally, we assessed the pain experienced during the OR. A total of 1166 OR were performed during the study period, of which 1058 (90.7%) ORs were included prospectively. Incomplete data meant that the remaining 9.3% were excluded. No complications were caused by sedation or general anaesthesia. Vaginal bleeding was observed in 2.8% of procedures, without any cases of intra-abdominal bleeding. An injury of pelvic structures (a ureteral lesion) occurred in one case. No case of pelvic infection, but one case of unexplained fever, was observed. A severe ovarian hyperstimulation syndrome (OHSS) occurred in 2.7% of cases. Although most patients tolerated the OR well, 3% of patients experienced severe to very severe pain after the OR and 2% of patients were still suffering from severe pain 2 days after the procedure. The pain level increased with the number of oocytes retrieved. About 0.7% of patients required hospitalization for pain treatment. Patients can be reassured that overall OR is a safe procedure. However, patients have to be counselled about the minor risks of the OR. The literature on complications is reviewed in the article.

Isolated pancreas rejection in combined kidney pancreas tranplantation.

The clinical success of pancreas transplantation is limited by the difficulty in diagnosing rejection. In simultaneous pancreas kidney (SPK) transplantation, the diagnosis of pancreatic rejection is particularly difficult in the absence of clinical evidence of kidney rejection. Moreover, patients receiving only pancreas grafts will not have a concomitantly grafted kidney to serve as a "sentinel" for rejection. Percutaneous pancreas graft biopsy has been reported in a few small series but has not been adopted for broad clinical use. We describe the evaluation of 69 consecutive episodes of suspected isolated pancreas allograft rejection by percutaneous pancreas allograft biopsy. These rejection episodes occurred in 41 patients with bladder-drained pancreas transplants (25 SPK, 14 pancrease after kidney transplants [PAK], amd two pancreas transplant alone [PTA]). The indications for percutaneous pancreas biopsy were a twofold or greater increase in serum amylase or lipase, or a sustained 40% to 50% drop in urine amylase in the setting of no evidence of renal allograft dysfunction in SPK transplants. Biopsies were performed with color-flow Doppler ultrasound localization using an 18-gauge automated biopsy needle. Pancreatic tissue adequate for histologic evaluation was obtained in 61 of 69 cases (88%). There were two cases of intraabdominal bleeding, one of which required surgical intervention; the other resolved spontaneously. Histologic assessment of the biopsies demonstrated varying degrees of acute cellular rejection in 48 of 61 specimens (79%). Twelve specimens (20%) were free of histologic evidence of rejection, and one specimen (2%) showed acute pancreatitis. At the time of suspected rejection mean serum amylase and lipase values were increased 3.6 and 8.3-fold, respectively, and urine amylase was decreased by a mean of 45%. We conclude that the commonly used markers for pancreas allograft rejection are only about 80% specific for acute rejection. Percutaneous pancreas allograft biopsy is safe and allows the avoidance of unnecessary antirejection therapy with its attendant side effects and cost.

Acute Posttraumatic Rupture of the Thoracic Aorta: An Eleven-Year Experience

An 11-year experience with 17 acute traumatic ruptures of the thoracic aorta is reviewed. Superior mediastinal widening on initial chest X-ray (CXR) was present in 15 patients. In 2 patients the mediastinum on CXR was initially normal but became wider with regular subsequent films. The diagnosis was made by aortography in 16 patients. All ruptures involved the aortic isthmus although one extended into the distal aortic arch. Emergency aortic repair was performed in all cases. Two had direct suture repair, 1 had a Dacron® patch, and the others required interposition tube grafts. Techniques used to enhance repair varied from a simple cross-clamp without heparinization to total cardiopulmonary bypass, deep hypothermia, and circulatory arrest. Four patients underwent surgery for other conditions prior to aortic repair (2 craniotomies, 2 laparotomies). There was 1 postoperative death and 2 cases of permanent paraparesis, both of which had been documented preoperatively. Aortography is a reliable diagnostic investigation in this condition. Repair should be performed in a center equipped with cardiopulmonary bypass. Surgical priority over the aortic repair should be given only to intracranial hemorrhage or selected cases of intraabdominal bleeding. Paraplegia can result from the injury as well as being associated with the aortic repair.

A Case of Intra-abdominal Bleeding Caused by Rupture of Splenic Angiosarcoma

A Case of Intra-abdominal Bleeding Caused by Rupture of Splenic Angiosarcoma

The Cases of Intra abdominal Bleeding by the Rupture of Hepatoma

The Cases of Intra abdominal Bleeding by the Rupture of Hepatoma