Case Of Double Primary Cancer Research Articles

Discordant Molecular Imaging Findings with 2-[18F]FDG and [68Ga]Ga-PSMA PET/CT in a Patient with Both Bladder and Prostate Cancer.

The prevalence of double primary prostate and bladder cancer is not uncommon. Though both share a common pathway of malignant transformation, they bear to differ in the case of 2-[18F]FDG PET/CT and [68Ga]Ga-PSMA uptake. We present a case of double primary cancer involving the bladder and prostate, where the prostatic primary showed intense [68Ga]Ga-PSMA uptake with non-avid skeletal and pulmonary metastases, which showed intense 2-[18F]FDG uptake, thus showing discordance due to different clonal origins.

同一肝亜区域内に混合型肝癌と肝細胞癌が存在した重複癌の1例―First case―

症例は62歳，男性．C型慢性肝炎を背景とした肝S8内に2個の腫瘍を指摘され，当院を受診した．術前画像診断では，S8a, S8cの2個の肝細胞癌と診断し，肝S8部分切除が施行された．術中所見では，S8aの病変は白色調，S8cは緑色調であった．術後の病理結果で，S8aは混合型肝癌，S8cは肝細胞癌であり重複癌の状態であった．術前のCT, MRIを振り返ると，S8aの混合型肝癌は，不整形で，wash outがなく肝細胞癌とするにはやや非典型的な所見であり，術前診断の重要性を再認識した1例であった．本症例は，同一肝亜区域に混合型肝癌と肝細胞癌が存在する極めてまれな重複癌であった．調べうる限り同様の報告はなく，若干の文献的考察を交えて報告する．

A rare case of double primary cancer of the colon with parotid gland metastasis

A rare case of double primary cancer of the colon with parotid gland metastasis

A Case of Double Primary Cancers in the Esophagus and Stomach

Double primary cancers are two independently developed cancers in an individual. There have been some reports on double primary cancer since Billroth reported it for the first time in 1879. Double primary cancer of the stomach and esophagus has been revealed a very low incidence worldwide. The incidence of an esophageal cancer with another primary cancer is reported to be 9.5~27%, but double primary cancers in the esophagus and stomach have been rarely reported to our knowledge. In this study, we present here a case of double primary esophageal and stomach cancer in a 66-year-old man because of progressive dysphagia.

A case of double primary cancers of uterine endometrium and bladder with unusual histology

A case of a moderate differentiated endometrial carcinoma of the uterus with a synchronous poorly differentiated bladder cancer is reported. A review of the literature revealed that simultaneous presentation of primary endometrial and bladder neoplasm is rare and usually related to low-stage bladder lesions in contrast to our case with undifferentiated and the deep myometrial invasion of bladder lesion. A 79-year-old woman with endometrial cancer stage IB was performed of total abdominal hysterectomy with bilateral salpingo-oophorectomy, pelvic and para-aortic lymph nodes dissection and adjuvant concurrent cisplatin-radiation therapy. After treatment, she complained intermittent gross hematuria. She was performed the bladder mucosal biopsy and fi nally diagnoses with poorly differentiated carcinoma of bladder. She received transurethral resection of bladder tumor alone without total cystectomy or any other adjuvant treatment due to her refusal. Her condition is tolerable except intermittent hematuria and anemia.

Diagnosis and treatment of multiple primary carcinomas

32 cases of double primary cancer had been treated in our hospital from January, 1984 to March, 1994. Among them, 21 cases in male and 11 cases in female, the ratio of male and female is 1.9:1, the age ranged from 37 to 84 years old, the median age was 60 years old. 8 of them were synchronous carcinoma and 23 were metachronous carcinoma, the period from first to second cancer ranged 8 months to 8 years and 3 months. 26 of the 32 patients were performed radical resection and radiotherapy and/or chemotherapy treatment. The postoperative survival rate of 1, 3 and 5 year’s were 100.0%, 65.3% and 42.3% respectively. 2 patients survived over 10 years with no tumor. The other 6 patients were later stage when fund the second primary cancer, palliative operations were only performed for them and they survived ranging from 5 to 15 months.

A CASE OF DOUBLE PRIMARY CANCERS IN STOMACH AND LUNG

We have experienced an extremely rare case of double primary cancers in stomach and lung. An 87-year-old male underwent a subtotal gastrectomy due to double stomach cancers 4 years previously. The pathological report suggested double primary cancers: Borrmann 3 type, advanced cancer and a IIa + Iic type early cancer with different histological findings. This time, a infiltrative shadow in his right lower lung was detected y chest X-ray, and double tumor shadows were found in S4 and S10 by chest CT. TV brushing cytology from the tumor of S10 suggested a malignancy. Therefore, partial bi-lobectomy of the right middle and lower lobes was performed with the aid of a thoracoscope. Pathological examination revealed double primary lung cancers, because the tumor in S4 was papillary adenocarcinoma and the other was poorly differentiated squamous cell carcinoma. Therefore, this case was extremely rare because of the double primary cancers in both stomach and lung. We could not find any other clinical report abot such a case.

CLINICAL EXPERIENCE WITH DOUBLE PRIMARY CANCER INVOLVING THE LUNG AND OTHER ORGANS

Thirteen cases of double primary cancer, arising in the lung and the other site including the stomach (7 cases), colon (3 cases), esophagus (1 case), uterus (1 case) or breast (1 case), were experienced in our department during the recent one decade from January 1979 to April 1989. These cases accounted for 7.0% of all cases of lung cancer treated during the same period. The digestive tract was predominant as the other site for both synchronous and metachronous double primary cancer. There was no significant difference in age, sex, or histological type. The 5-year-survival rate was 17.0% in 12 cases in which operation was performed for lung cancer. Of these, death occurred in 6 cases. Two deaths were caused by cancers other than lung cancer, and one by a complication after surgery for a cancer other than lung cancer. The 5-year-survival rate for the remaining 9 cases was 28.2%. In the treatment and follow-up of lung cancer, more attention should be paid to the possibility of a secondary primary cancer, especially in the digestive tract. Earlier diagnosis and aggressive treatment may improve the survival rate.