Case Of Cutaneous Rosai-Dorfman Disease Research Articles

A case of cutaneous Rosai-Dorfman disease after regression of herpes zoster

A case of cutaneous Rosai-Dorfman disease after regression of herpes zoster

A case of cutaneous rosai-dorfman disease diagnosed by fine needle aspiration cytology

<p class="abstract">A 30 year old female presented with a swelling in the back of a few weeks duration. Clinical examination revealed no other abnormalities. Fine needle aspiration cytology (FNAC) was suggestive of Rosai- Dorfman disease (RDD). The diagnosis was confirmed by biopsy and immunohistochemistry. FNA diagnosis of purely cutaneous RDD has very rarely been reported.</p>

Cutaneous Rosai-Dorfman disease in a middle-aged man: A case report.

The present study describes a case of cutaneous Rosai-Dorfman disease (CRDD). The clinical manifestations and therapeutic options of CRDD vary, and the etiology of the disease is still unknown. The clinical manifestations include single or multiple yellow-red to brown or purple papules, nodules and/or plaques, with the face being the most frequently affected site. A 52-year-old man presented with an 8-month history of multiple lesions on his face. Physical examination revealed a number of yellow-red papules and nodules, the majority of which had coalesced into plaques. The histological finding from a red papule showed a dense, dermal infiltrate, which was predominantly composed of large histiocytes, strongly positive for S-100 and cluster of differentiation (CD)68 but negative for CD1a, mixed with aggregates of lymphocytes and scattered plasma cells and eosinophils. The patient showed only a marginal improvement with a month of oral, low-dose prednisone.

Cutaneous Rosai-Dorfman Disease Recurrence in Nasal Region

Rosai-Dorfman disease (RDD), also known as sinus histiocytosis with massive lymphadenopathy, is a benign non-Langerhans cell histiocytic proliferation which was first described in 1969 by Rosai and Dorfman. The disease most commonly involves the lymph nodes but can be seen in virtually any part of the body. The clinical presentation is usually painless massive bilateral cervical lymphadenopathy. The cutaneous form of Rosai-Dorfman disease (CRDD) is a rare entity that manifests solely with skin papules or nodules and it does not present with the usual myriad of symptoms of classical RDD. Here, we report a case of cutaneous RosaiDorfman disease in a 43 year old woman that recurred in the nasal region postoperatively.

Case for diagnosis

Cutaneous Rosai-Dorfman disease is a rare, lymphoproliferative disease. It is benign and self-limited, only involves skin and subcutaneous tissue and typically occurs as histiocyte-rich inflammatory infiltrates, manifesting as erythematous to brown papules, plaques, or nodules, without predilection for site. The authors describe a case of cutaneous Rosai-Dorfman disease in a 72-year-old man who presented erythematous and scaled plaque on the right neck for three months without systemic symptoms. Owing to local involvement, the patient received a surgery to exsect the lesion completely and remained asymptomatic with no signs of recurrence at the 9-month follow up.

Cutaneous Rosai-Dorfman Disease: Comprehensive Review of Cases Reported in the Medical Literature since 1990 and Presentation of an Illustrative Case

The latest comprehensive review of primary cutaneous Rosai-Dorfman disease was published as part of an exhaustive survey of sinus histiocytosis with massive lymphadenopathy in 1990. Since then, much progress has been made in the understanding of malignant lymphoma and benign disorders of lymphoid and histiocytic origin. We reviewed cases of primary cutaneous Rosai-Dorfman disease published since 1990 and discuss their clinical and pathologic features, comparing them with cases of systemic Rosai-Dorfman disease. We conducted a search of the National Library of Medicine PubMed database for cases of cutaneous Rosai-Dorfman disease reported in the English-language medical literature since February 1990. We identified 72 patients with cutaneous Rosai-Dorfman (female to male ratio 1:0.5). The gross appearance and number or distribution of lesions were highly variable. Abnormal laboratory data included peripheral blood cytopenias (10 patients) and increased gammaglobulin fraction (10 patients). The response to treatment was variable. Purely cutaneous disease without the characteristic lymphadenopathy is rare but has been increasingly reported in the literature. Compared with patients with systemic Rosai-Dorfman disease, patients with primary cutaneous Rosai-Dorfman disease are older, women are more commonly affected, and whites are more likely than blacks to be afflicted.

Crystal Deposition in a Case of Cutaneous Rosai-Dorfman Disease

Rosai-Dorfman Disease (RDD) is an idiopathic reactive proliferation of distinctive histiocytes that have abundant cytoplasm and commonly exhibit intracytoplasmic ingestion of inflammatory cells (emperipolesis). The histiocytes are immunopositive for S100 protein and are typically associated with an infiltrate of lymphocytes, plasma cells, and neutrophils. The classic clinical presentation is massive enlargement of (usually) cervical lymph nodes with a histologic appearance that mimics exaggerated sinus histiocytosis. RDD can also involve extra-nodal sites and skin involvement is common either as part of disseminated disease or as a result of primary disease. We report an exceptional case of cutaneous RDD with crystal deposition in a young male presenting with skin nodules. Skin biopsy showed classic features of cutaneous RDD with the additional feature of conspicuous rhomboidal and needle-shaped crystals within the cytoplasm of many lesional plasma cells, histiocytes, and also in an extra-cellular location. The plasma cells were polyclonal by light chain immunostaining. Crystal deposition has not been reported to date in RDD and is likely a result of the reactive plasma cell proliferation.

Cutaneous Rosai-Dorfman disease

To investigate the clinicopathologic feature, immunophenotype and differential diagnosis of cutaneous Rosai-Dorfman disease (CRDD). Clinical manifestation, morphologic features and immunohistochemical staining were studied in 8 cases of CRDD. All 8 patients presented with multiple papules, nodules and/or coalescent patches or plaques distributing over the extremities or trunk, without lymphadenopathy or other systemic abnormalities. Microscopically, the lesions were located intradermally and/or subcutaneously. CRDD was characterized by the presence of S-100 positive histiocytic cells exhibiting emperipolesis, accompanying with infiltration of mixed inflammatory cells. Fibrosis, somewhere in vague storiform pattern due to stromal responses, with distribution of individual neutrophil microabscess was seen in cases with a long course of illness. Dilated vascular spaces in dermis containing numerous large typical histiocytes were seen in 2 cases. CRDD is a benign, persistent proliferative disease of histiocytes. Systemic involvement is rare, outcome favorable. It should be differentiated from other types of histiocytosis, dermatofibrosarcoma protuberans, xanthoma and lymphoproliferative disorders. Immunohistochemical staining for S-100 protein and CD68 is helpful in making a correct diagnosis.

Ｃｕｔａｎｅｏｕｓ Ｒｏｓａｉ‐Ｄｏｒｆｍａｎ ｄｉｓｅａｓｅの１例

We report a case of cutaneous Rosai-Dorfman disease (RDD) rising in a 52-year-old Japanese female with two nodules: one was a red nodule on her cheek and the other was a subcutaneous nodule on her chest. Histopathological analysis revealed that the nodules were composed of many histiocytes that were positive to S100, but negative to CD1a showing “emperipolesis”. We diagnosed her with cutaneous RDD based on the histological findings since she had no other lymphadenopathy or extranodal involvement. RDD derived from the skin without lymph node involvement is rare worldwide with approximately 50 cases reported. No cases have been reported in Japan. [Skin Cancer (Japan) 2004; 19: 124-127]

Cutaneous Rosai-Dorfman disease presenting as pustular and acneiform lesions

We report 2 cases of cutaneous Rosai-Dorfman disease (CRD) presenting with pustular and acneiform lesions. To our knowledge, these are the first reports of CRD presenting in this pattern. One patient had spontaneous resolution of the lesions, whereas the other was treated with cryotherapy with clinical improvement. We present a review of the literature regarding CRD and highlight the benign nature of this condition. (J Am Acad Dermatol 1999;41:335-7.)