Cases Of Cerebrospinal Meningitis Research Articles

An isolated case of cerebrospinal meningitis in one of H.M. ships

An isolated case of cerebrospinal meningitis in one of H.M. ships

Investigations On Six Cases of Cerebro-Spinal Meningitis

Investigations On Six Cases of Cerebro-Spinal Meningitis

LONDON

<h3>Recrudescence of Cerebrospinal Fever</h3> Cerebrospinal fever, which has recently been reported in various parts of the world, has now been observed in England. Periodic increases in the incidence of this relatively rare disease are not unusual. The total notified cases in England and Wales in 1929 was 650, which is above the average, and in 1930, 666. In the present year 230 cases have already been reported among civilians. They have shown a scattered distribution over thirty-six counties, but there has been some concentration in the West Riding of Yorkshire, where seventy-nine cases have occurred. In the army a local prevalence of influenza has been associated with a number of cases of cerebrospinal meningitis. Thus, since January 31, thirteen cases have been notified in the Aldershot Command and six among the Air Force at Uxbridge. At Aldershot, with the exception of a fatal case in a nurse in attendance on

Observations on vaccine therapy and out-vaccine therapy for epidemic cerebrospinal meningitis

There is no well-collected material on the incidence of epidemic cerebrospinal meningitis among children in the USSR. The most comprehensive monograph by Breitman is more than 20 years old. Judging by anecdotal evidence and the rather large number of papers on the subject, cases of the disease are widespread and frequent, and in recent years small epidemic outbreaks and sporadic cases have been occurring more and more frequently. Over a period of 30 years, according to Prof. Kisel, 80 cases of cerebrospinal meningitis have occurred in the former Olginsky Children's Hospital in Moscow. The clinic of infants of the 2nd M. G. W. (Frishman) counts 35 cases in a shorter period. Our material indicates a higher incidence of the disease in children specifically in recent years, with infants being affected more frequently.

CEREBROSPINAL MENINGITIS WITH PURULENT IRIDOCHOROIDITIS WITH RECOVERY

The following case of cerebrospinal meningitis is presented as evidence of the striking effect of specific serum therapy not only on the disease itself, but also on one of the less common complications. REPORT OF CASE E. A., a girl, aged 18 months, whose father and mother are both healthy and born in the United States, was referred from the New York City Department of Health, Oct. 29, 1923, for admission to the Babies' Hospital and was under observation on the service of the late Dr. L. Emmett Holt for thirty-three days. The patient was the youngest of four children; the others were apparently normal in every respect. Prior to the onset of the present illness the patient had been healthy, well nourished and well developed. She had been nursed for nine months, with supplementary feedings of cereals and fruit juice at six months. At nine months she was given

EPIDEMIOLOGICAL RÔLE OF THE CASE OF CEREBROSPINAL MENINGITIS

That carriers are not the infecting agent in most cases of cerebrospinal meningitis is suggested. It does not seem probable that meningococci are present in the naso-pharynx of premeningococus cases in numbers large enough to be a menace. These findings rest on negative results of swabbings taken shortly before the onset of the disease.

Precipitin response in the blood of rabbits, following subarachnoid injections of horse serum

During the treatment of cases of cerebrospinal meningitis with antimeningococcic serum in a large Army hospital, a curious reaction was repeatedly observed. This appeared in patients who, after having received several intraspinous treatments with serum, were given serum intravenously. While such injection was made into the blood stream, or immediately thereafter, some of the following signs and symptoms frequently appeared: flushing, sudden feeling of warmth, restlessness,—then, pallor, dyspnea, cyanosis, vomiting, and prostration. Epinephrin and atropin hyperdermatically, induced relief. These manifestations, apparently anaphylactic, occurred only after several days of intraspinous treatments had elapsed before initial intravenous serum therapy, but had no relation to the time of the last intraspinous injection. They were not noted when combined intravenous and intraspinous therapy was applied from the outset. Similar observations are described by Stone and Truit in their report of a large series of cases of meningitis at Camp Funston, and Haden confirms them in one of his case reports of meningitis. With this experience in mind, horse serum was injected into rabbits intraspinously, and the resulting precipitin formation in the blood was compared with that induced by similar intravenous injections. In a few instances, anaphylactins were studied. Normal horse serum, without preservative, was used throughout these experiments. This was injected into the subarachnoid space of rabbits by introducing a No. 24 Luer needle attached to a glass syringe, through a sterile field just below the occipital ridge in the mid-line. The needle was carried forward and slightly downward until it punctured the occipito-atlantoid ligament. A yield of from 0.5 C.C. to 1.0 C.C. of spinal fluid was thus readily obtained. Leaving the needle in place, and disconnecting the syringe, a second syringe with a correct amount of serum was then attached.

THE CHRONIC FORM OF MENINGOCOCCUS MENINGITIS

Cerebrospinal meningitis with a prolonged course presents two varieties. In one we observe only recurrences or episodic meningeal manifestations. Here the patient during the intervals appears to be in perfect health. Nevertheless, suddenly or insidiously the symptoms return either in a slight or grave form. The intervals may last either a few days or a few weeks. The other variety which is the subject of the present contribution, concerns cases of cerebrospinal meningitis the evolution of which is continuous. While in the literature are mentioned a few such isolated cases under different captions, nevertheless their chief characteristic features have not been sufficiently emphasized by various authors with the exception of Robert Debre, pupil of Netter. In 1845 Tungel 1 for the first time speaks of disturbances in the brain tissue proper in the course of a prolonged case of cerebrospinal meningitis. The next two earliest records we find by Rilliet 2 and

A Case of Cerebrospinal Meningitis Successfully Treated by Intraspinal and Intraventricular Administration of Anti-Meningitis Serum

A Case of Cerebrospinal Meningitis Successfully Treated by Intraspinal and Intraventricular Administration of Anti-Meningitis Serum

A Case of Cerebrospinal Meningitis, with Paratyphoid “A” Fever, Complicated by Hernia of the Small Intestine Through the Mesentery; Operation, Recovery

A Case of Cerebrospinal Meningitis, with Paratyphoid “A” Fever, Complicated by Hernia of the Small Intestine Through the Mesentery; Operation, Recovery

FIVE CASES OF CEREBRO‐SPINAL MENINGITIS.

Medical Journal of AustraliaVolume 2, Issue 18 p. 418-419 Report of Case FIVE CASES OF CEREBRO-SPINAL MENINGITIS.† Christine Rivett M.B., Ch.M., Christine Rivett M.B., Ch.M. Resident Medical Officer Hospital for Sick Children, BrisbaneSearch for more papers by this author Christine Rivett M.B., Ch.M., Christine Rivett M.B., Ch.M. Resident Medical Officer Hospital for Sick Children, BrisbaneSearch for more papers by this author First published: 01 October 1915 https://doi.org/10.5694/j.1326-5377.1915.tb17097.x †Read at a meeting of the Queensland Branch of the British Medical Association on September 3, 1915. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume2, Issue18October 1915Pages 418-419 RelatedInformation

ACCIDENTS FOLLOWING VACCINATION

THIllS study is suggested because of the increasing difficulty in securing compliance with school requirements in reference to vaccination, due to the activity of antivaccinationists in exaggerating both the number and character of these unfortunate accidents. Cancer, consumption, typhoid fever, ulcerated stomach, leprosy, diphtheria, syphilis and many other diseases have been charged to vaccination, but these require no discussion here. Several cases of cerebro-spinal meningitis have been reported as following vaccination; but here again no causal relation has been established. Septicemia in various forms, due to invasion of pathogenic organisms at some stage of the -vaccinal process from accident or carelessness is occasionally noted. Recently a Philadelphia court awarded a negro $5,000 damages for the loss of a leg, said to be due to septicemia, following vaccination by a city physician in 1910. Carelessness was alleged. The verdict, however, has been set aside by a higher court. A case is now pending in Chestertown, Md., where the commissioners are sued for $10,000 for the death of a negro child through alleged carelessness in vaccination by the county physician. Recently, three cases of anterior poliomyelitis following vaccination in from ten to twenty days, have been reported from New York State. So far as is known, these children did not come in contact with each other or with other cases of poliomyeltis, so that the parents naturally concluded that vaccination was at least a factor in some way. While cases of the classes enumerated are a drawback to enforcing vaccination, they are insignificant as compared with tetanus, and it is in a study of this disease in its relation to vaccination that we are chiefly interested. I have been able to secure more or less complete histories of 82 cases occurring in the United States and Canada since 1899. Some of these, prior to 1902, were discussed by Wilson,* and are taken from his paper; some more recent Philadelphia cases are taken from Wadsworth'st report of coroner's cases and from records of the coroner's court. I wish here to express to Doctor Wadsworth my appreciation of his assistance in securing copies of these records. First analyzing these somewhat in detail we note the following facts. Case 1. Pushed against door by playmate at school. Scab torn off. Tetanus developed in 24 hours. Case 2. Large, deep ulcer present 20 days after vaccination. Arm dirty.

MENINGOCOCCUS ENDOCARDITIS, WITH SEPTICEMIA

Meningococcus septicemia was first reported by Gwyn 1 in 1899. The case was one of epidemic meningitis complicated by acute arthritis. The meningococcus was isolated from the spinal fluid, synovial fluid, and the blood. Cochez and Lemaire 2 in 1901 were able to demonstrate the meningococcus in the blood of two meningitis patients. Jakobitz, 3 Martini and Rohde, 4 Lenhartz, 5 Marcovitch, 6 Robinson, 7 and Duval 8 have since made similar reports, the septicemia in all these cases being associated with meningitis. Elser, 9 examining the blood in forty-one cases of cerebrospinal meningitis, found the meningococcus in ten, or about 25 per cent. It has been observed that in most instances where the meningococcus has been found in the circulating blood, the disease has been fatal, and some form of extrameningeal lesion has been present. The endothelial-lined cavities, such as the joints, pleura, pericardium and endocardium have been the sites of these complicating

On three cases of cerebro‐spinal meningitis, associated respectively with bacillus anthracis, bacillus typhosus, and bacillus enteritidis (Gaertner)

On three cases of cerebro‐spinal meningitis, associated respectively with bacillus anthracis, bacillus typhosus, and bacillus enteritidis (Gaertner)

A Sporadie Case of Cerebro-spinal Meningitis, with a Description of the Pathological and Bacteriological Findings

A Sporadie Case of Cerebro-spinal Meningitis, with a Description of the Pathological and Bacteriological Findings

NOTES ON THE INTRACELLULAR OCCURRENCE OF DIPLOCOCCUS PNEUMONIÆ IN CEREBROSPINAL MENINGITIS.

That the diplococcus pneumoniae, in common with other micro-organisms, may occasionally be found within leucocytes as the result of phagocytosis in inflammatory processes, has been frequently noted by numerous observers. Its extracellular position, however, in the exudate in cerebrospinal meningitis is so markedly the rule that the point is used as a differential characteristic between the organism and diplococcus intracellularis meningitidis. Consequently, the preponderatingly intracellular position of diplococcus pneumoniae in the following four cases of cerebrospinal meningitis makes them of sufficient interest to warrant their record. Case 1. —In June, 1898, a specimen of cerebro-spinal fluid from a case of cerebrospinal meningitis, removed by lumbar puncture during the third week of the disease, showed in direct cover-slip preparations, numerous encapsulated, lanceolate, Gram-staining diplococci, most of which were intracellular. Cultures in broth, on plain and blood agar, and Loffler's blood serum developed, without admixture of other organisms, a diplococcus, which, despite

THE PATHOLOGY OF EPIDEMIC CEREBROSPINAL MENINGITIS.

In 1887 Professor Weichselbaum1found a peculiar diplococcus which he called diplococcus intracellularis, in six cases of cerebrospinal meningitis, whose clinical histories corresponded exactly to that of the epidemic type of this disease, and not at all to that caused by the pneumococcus. He described these cocci as being particularly found within the cells of the exudate, always occuring in the form of a diplococcus with the opposite sides flattened. It grew best at body temperature, not well on blood or potato. Considerable confusion existed until 1895, when Jager2published his observations in the cases of ten soldiers dying of the epidemic form of the disease. During this period, up to the time of Jager's article, a number of articles appeared claiming that either all forms of meningitis were caused by the pneumococcus, and that this was but a localization of the general infection with this germ, or

REPORT OF A CASE OF EPIDEMIC CEREBRO-SPINAL MENINGITIS WITH RECOVERY FOLLOWING LUMBAR PUNCTURE.

In theJournal of the American Medical Associationfor July 2, Dr. J. B. Herrick reports a case of cerebro-spinal meningitis, in the postmortem of which the diplococcus intracellularis meningitis of Weichselbaum was demonstrated in the meningeal exudate. From this fact and from the large number of cases of meningitis observed in Chicago during the last months, the Doctor concludes that we have to deal with a mild epidemic, although the micro-organism had never been demonstrated before, probably because a bacteriologic examination has been made in but very few cases. The following case further proves the existence of genuine epidemic meningitis in Chicago at the present time: The patient, a Russian laborer, 45 years old, previously in good health, was admitted to treatment under Prof. Geo. F. Butler in the Cook County Hospital, June 17, 1898. Five-days before admission he had been suddenly taken with vomiing and diarrhea, followed by

A Case of Cerebro-Spinal Meningitis due to the Bacillus of Eberth

A Case of Cerebro-Spinal Meningitis due to the Bacillus of Eberth

A Case of Cerebro-Spinal Meningitis of the Pneumonic Type, with Painful Joints and Worms

A Case of Cerebro-Spinal Meningitis of the Pneumonic Type, with Painful Joints and Worms