Case Of Breast Metastasis Research Articles

A Case of Breast Metastasis from Uterine Leiomyosarcoma

症例は58歳，女性．子宮平滑筋肉腫術後2年で骨転移を認めた．その際に，右乳房に3mmの腫瘤を認めた．骨転移に対する治療後のCTにて増大を指摘され，当科を紹介受診となった．マンモグラフィでは右乳房C領域に境界明瞭の円形腫瘤を認め，乳房超音波検査では右Cの乳腺後隙に近くに6mmの比較的境界明瞭な円形腫瘤を認めた．以前のCTより増大傾向であり，確定診断のために針生検による組織診を行った結果，子宮平滑筋肉腫の乳房転移と診断された．その後，当院婦人科にてドキシルビシン単剤による化学療法を開始し，現在継続中である．乳房以外の臓器からの乳房転移は全乳房悪性腫瘍の0.5～2.0％程度と報告されており，まれな病態であり特徴的な画像所見はなく，原発性乳癌や良性病変との鑑別は難しい．悪性疾患の既往がある症例に乳房に腫瘤と認めた場合は，乳房転移の可能性を念頭に置く必要があり，確定診断を行う必要があると考えられた．

A Case of Breast Metastasis from Ovarian Cancer Requiring Differential Diagnosis from Invasive Ductal Carcinoma

A Case of Breast Metastasis from Ovarian Cancer Requiring Differential Diagnosis from Invasive Ductal Carcinoma

Multimodality Imaging Findings of Breast Metastases from Malignant Melanoma: A Case Series

Breast metastases stemming from extramammary malignancies are rare, occurring in approximately 1.3–2.7% of breast malignancies. The most prevalent are metastases belonging to the primary carcinoma of the contralateral breast, followed by lymphoma and malignant melanoma. Breast metastasis is to be suspected in patients with previous history of malignant melanoma who present with a breast mass. Distinguishing metastasis from primary breast neoplasms is a challenging task. Accurate diagnosis is crucial because the prognosis and management differ significantly between primary and secondary malignancies of the breast. Imaging features are non-specific on mammography and ultrasound. There have been several reports on the magnetic resonance imaging (MRI) characteristics of breast metastasis originating from malignant melanoma; however, only few studies have described the diffusion weighted imaging (DWI) feature and the apparent diffusion coefficient (ADC) value. In this study, we report the multimodality imaging features of three cases of breast metastases from malignant melanoma. We particularly focus on MRI findings, such as DWI feature and ADC value and compare them with the MRI features reported in the literature.

A rare case of gastric cancer with bilateral breast metastasis during pregnancy

Gastric cancer is rare during pregnancy and often diagnosed at a later stage due to overlapping symptoms of pregnancy. Breast metastasis of gastric cancer is another uncommon entity. We present a rare case of breast metastasis of gastric cancer during pregnancy. A 26-year-old female was diagnosed with gastric cancer at 14 weeks of gestation and underwent total gastrectomy. She rejected adjuvant chemotherapy and continued pregnancy without any follow-up. Cancer recurred in bilateral breasts at 34th week of gestation mimicking primary inflammatory breast cancer. It was difficult to diagnose breast metastasis during pregnancy because of overlapping pregnancy symptoms. Following an unresponsive period to antibiotherapy, a fine needle biopsy on breast was performed and signet cell adenocarcinoma metastasis was determined. We started chemotherapy after delivery. There was a near complete response after first line of chemotherapy. Unfortunately, cancer was relapsed within three months and we started second-line chemotherapy. To our knowledge, this is the fourth case reported in medical literature of gastric cancer presented with breast metastasis during pregnancy. We will try to draw attention to diagnosis, treatment and different presentation of gastric cancer during pregnancy with review of the literature.

Three Cases of Breast Metastases from Lung Cancer and Systematic Review of the Literature

Despite the high prevalence of lung cancer among other primary tumors, metastasis of this particular malignancy in the breast is very rare. We report three new cases of lung cancer with breast metastases and discuss radiological and clinical findings. Radiologically, each case displayed different characteristics. First, one of them had bilateral superficially and deeply located irregular lesions. Second, the patient presented with findings similar to inflammatory breast cancer. The third case had a circumscribed mass, resembling a benign complicated cyst. To guide clinicians for proper patient management, radiologists should be aware of the scope of typical and atypical imaging findings of metastatic involvement of the breast.

Breast metastasis of anaplastic oligodendroglioma: a case report.

Extracranial metastasis of primary brain tumors is rarely observed. Of all brain malignancies, glioblastomas, medulloblastomas and astrocytomas metastasize most frequently. Metastasis of oligondendroglioma is rare. We present a case of breast metastasis in a 58-year-old man with an anaplastic oligodendroglioma.

胃癌乳腺転移の1例

胃癌乳腺転移の稀な1例を経験した．症例は69歳，女性．2014年12月に胃癌に対して胃全摘術を施行．T4aN3bM1（P1，CY1） Stage IV，根治度C，組織型は印環細胞癌であった．術後化学療法は患者の同意が得られず経過観察のみ行った．2016年1月より左乳房全体に腫瘤を自覚し，乳腺針生検で印環細胞癌を認め，免疫組織化学で胃癌組織と一致したことから胃癌乳腺転移と診断した．胃癌乳腺転移の本邦報告例は，1980年から検索すると自験例を含め僅か29例であった．これらを文献的にまとめると，比較的若年女性に多く，印環細胞癌または低分化腺癌が多いという特徴がみられた．乳腺転移時には既に他臓器転移を認める進行例が多く，その後の1年生存率も14.9％と予後不良であった．このような症例では乳房への局所治療の意義は低く，予後改善には有効性の高い全身治療の臨床研究が求められる．

直腸癌乳房転移の1例

乳房は他臓器からの転移をきたしにくい臓器であるが，今回直腸癌が乳房へ転移した稀な1例を経験した．症例は51歳，女性．IV期直腸癌の既往があり，転移性肺腫瘍術後4カ月目に左乳房腫瘤を自覚し当科を受診した．左上外側に3cm大の境界明瞭腫瘤を触知し，エコーでは左乳房皮下に2cm大の腫瘤を認めた．腫瘍マーカーの上昇があったため，直腸癌乳房転移の可能性を考えFDG-PETを施行したところ，左乳房と閉鎖リンパ節に集積を認めた．エコー下マンモトーム（MMT）生検で直腸癌乳房転移と診断した．閉鎖リンパ節への転移を伴っていたため，全身治療を優先させ薬物治療を開始した．腫瘍は一旦縮小したものの再増大し，皮膚へ露出したため局所コントロール目的に乳房転移診断から4カ月目，乳房部分切除を施行した．

Breast Metastasis of Serous Ovarian Papillary Carcinoma: A Report of Two Cases Diagnosed by Fine-Needle Aspiration

Breast metastases from gynecologic cancer are infrequent and are mainly from the ovary. They usually appear in advanced stages and have poor survival rates after diagnosis. Two cases of breast metastasis of serous ovarian carcinoma are presented. In both cases fine-needle aspiration (FNA) study of breast revealed a lesion with morphologic characteristics of serous carcinoma, while one of them was with immunocytochemical study. Origin was confirmed by histological examination of this lesion.

原発性乳癌との鑑別を要した前立腺癌両側乳腺転移の1例

症例は80歳，男性．進行性前立腺癌（T3N1M1 Stage IV）にてホルモン療法開始した．3年9カ月経過後右乳房腫瘤を認め右乳房部分切除術施行し充実腺管癌の病理診断であった．その後，経過観察をしていたところ11カ月後に左乳房腫瘤出現し左乳腺腫瘍摘出術を施行し充実腺管癌の病理診断であった．本症例は，当初，両側乳腺腫瘍ともに浸潤性乳管癌（充実腺管癌）との病理組織報告であったが，追加検索の結果，両腫瘍ともH.E.染色にて乳管内に腫瘍病変を確認することはできなかったこと，免疫染色にてER陰性，PgR陰性，GCDFP-15陰性，CK7陰性，CK20陰性であり原発性乳癌は否定的で，その一方PSA陽性という結果であった．臨床経過・画像所見・病理所見を総合的に検討し，前立腺癌両側乳腺転移との診断に至った．今回原発性乳癌との鑑別を要した前立腺癌両側乳腺転移の1例を経験したので，文献的考察も加え報告する．

Breast Metastasis of Anaplastic Oligodendroglioma: A Case Report

Extracranial metastasis of primary brain tumors is rarely observed. Of all brain malignancies, glioblastomas, medulloblastomas and astrocytomas metastasize most frequently. Metastasis of oligondendroglioma is rare. We present a case of breast metastasis in a 58-year-old man with an anaplastic oligodendroglioma.

Metastatic hepatocellular carcinoma presenting as gynecomastia in male: A diagnostic dilema in fine needle aspiration cytology

Metastatic hepatocellular carcinoma presenting as gynecomastia in male: A diagnostic dilema in fine needle aspiration cytology

術前，原発性乳癌と診断された卵巣癌乳腺転移の1例

術前，原発性乳癌と診断された卵巣癌乳腺転移の1例

Breast metastases from a floor of the mouth carcinoma

Metastases to the breast from extramammary tumours are uncommon and metastatis of floor of the mouth carcinoma to the breast is extremely rare. The clinical outcome of these patients remains dismal. We report the case of breast metastases from a floor of the mouth carcinoma successfully treated by conservative surgery and adjuvant radiotherapy with no demonstrable metastases 33 months after the initial diagnosis.

Metastatic Hurthle Cell Carcinoma of the thyroid presenting as a Breast Lump: A Case Report

BackgroundHurthle cell carcinoma of the thyroid is a rare form of thyroid cancer. It may present as a low grade tumour or can present as a more aggressive metastatic carcinoma. Hurthle cell carcinoma has the highest incidence of metastasis among all differentiated thyroid cancers. Most commonly haematogenous spread to lungs, bones and brain, however spread to regional lymph nodes is not uncommon. The breast is a rare site for metastasis from extramammary sources. We present the first case of breast metastasis from Hurthle cell carcinoma of the thyroid.Case presentationWe report a 77 year old lady who had total thyroidectomy and bilateral neck dissection followed by radiotherapy for a high grade metastatic Hurthle cell carcinoma of the thyroid. Ten months later she presented to the breast clinic with left breast lump and a lump at the left axilla. Fine needle aspiration cytology of the lumps and histology after wide local excision of the breast lump confirmed metastatic Hurthle cell carcinoma.ConclusionThe presence of breast lumps in patients with history of extramammary cancer should raise the possibility of metastasis.

Metastasis of Giant Cell Tumor to the Breast: Case Report and Review of the Literature

Breast cancer is the most common type of malignancy in women. Of all breast cancers, 0.5-3% involve metastasis of a non-breast malignancy to the breast. Metastasis of soft tissue tumors to the breast is rarely seen. In particular, metastasis of a giant cell tumor to the breast has never been reported in the literature. We present here a case of breast metastasis in a 44-year-old woman with a diagnosis of malignant giant cell tumor originating from the distal radius and metastatic to the lung, who had been treated with radiotherapy, surgery and chemotherapy.

Breast metastases from colorectal carcinoma

A case history is presented of a 53-year-old woman with an incidental finding of a breast lump, identified after having had chemotherapy for lung metastases from a rectal carcinoma. Clinical examination, ultrasound, mammography, fine needle aspiration and core biopsies could not prove definitively whether the breast lump represented a metastasis from colorectal carcinoma. Following local excision, the final diagnosis of metastatic colorectal carcinoma to the breast was based on the absence of any site of origin within the breast (i.e. no surrounding DCIS) and on the expression of cytokeratin CK7 and CK20 on immunohistochemistry. Postoperative chemotherapy was initiated. Four months later, although without local recurrence in the breast, the patient developed cutaneous metastatic deposits and active treatment was stopped. A review of other cases of breast metastases from extramammary sources is presented. Possible mechanisms for this rare and unusual phenomenon are discussed.

A CASE OF BREAST METASTASIS FROM CARCINOMA OF THE COLON

Metastatic carcinoma of the breast from extramammary carcinoma is unusual, especially from carcinoma of the colon. A case of breast metastasis from carcinoma of the colon is reported. A 72-year-old woman was performed a left hemicolectomy for cancer of the descending colon (Stage IV) in June 1996. Lung metastasis was detected in September 1997. Circumscribed left breast tumor with a rapid growth was detected in September 1998, and a fine-needle aspiration cytology resulted in class V (adenocarcinoma). Extirpation of the tumor was performed under a suspicion of breast metastasis from carcinoma of the colon. The tumor was capsulated and measured 1.8cm in diameter. The tumor was diagnosed as breast metastasis from extramammary carcinoma histologically, because moderately differentiated adenocarcinoma was distributed in periductal and perilobular areas in absence of intraductal and intralobular proliferation. The tumor was histologically and immunohistochemically similar to the previously operated colon carcinoma. We diagnosed the tumor as breast metastasis from carcinoma of the colon. She died of growing lung metastasis from the colon carcinoma in April 1999.