Cases Of Blastomycosis Research Articles

A Case of Systemic Blastomycosis, with Multiple Cutaneous and Snbcutaneous Lesions

A Case of Systemic Blastomycosis, with Multiple Cutaneous and Snbcutaneous Lesions

THE MORPHOLOGY AND BIOLOGY OF THE PARASITE FROM A CASE OF SYSTEMIC BLASTOMYCOSIS.

The observations recorded in this paper were made on the parasites obtained in the tissue and by artificial culture from the case of fatal systemic blastomycosis reported by Ormsby and Miller.¹We wish here to acknowledge their assistance in the work done and kindness in allowing us to use the material from their case. In May, 1894, Gilchrist²described in tissues from a skin lesion the spherical, double-contoured, budding microörganisms which have since been observed in about thirty-five reported cases. In this case cultures were not made and little was known of the biology or nature of the parasite. In November of the same year Busse³reported a case of systemic infection resulting fatally in which a similar parasite was described as the etiologic factor. Cultures were made from this case and the organisms extensively studied by Buschke.⁴In culture the organism grew by budding, and mycelial

A CLINICAL REPORT OF A CASE OF BLASTOMYCOSIS OF THE SKIN FROM ACCIDENTAL INOCULATION.

The subject of this report is a physician, 28 years of age, who has had unusually good health, with no history of specific or venereal disease or tuberculosis or any tuberculosis in the immediate family. On December 4, at an autopsy on a case of systemic blastomycosis, he accidentally inflicted a very slight skin wound with the point of a needle on the palmar surface of the left index finger, just in the fold at the junction of the proximal and middle phalanges. The wound was insignificant and apparently healed. At the end of about one week a very small pustule appeared at this point. This was opened and a small drop of pus removed. It was not noticed again until after several days, when a small pustule again appeared and a small drop of pus was evacuated, as before. The affected area was very small, about the size of a pin head or less. The minute pustule was covered by a very thin layer, probably only the epidermis.

FURTHER REPORT OF A PREVIOUSLY RECORDED CASE OF BLASTOMYCOSIS OF THE SKIN; SYSTEMIC INFECTION WITH BLASTOMYCES; DEATH; AUTOPSY.

<h3>INTRODUCTORY NOTE BY DR. MONTGOMERY.</h3> I reported this case before the meeting of the American Dermatological Association in 1900¹as a case of blastomycosis of the skin (blastomycetic dermatitis of Gilchrist), in which death finally occurred from miliary tuberculosis of the lungs and other organs. In explanation, I would state that I was away from Chicago during the last weeks of the man's illness and at the time of his death. My friend, the late Dr. D. D. Bishop, in whose charge I left the case, wrote me that the autopsy showed the man died of miliary tuberculosis. Up to this time the diagnosis of the cutaneous lesions had not been definitely determined, though they had been carefully studied both clinically and histologically by a number of competent observers. The case was now considered an unusual form of cutaneous tuberculosis followed by systemic infection. I gave Dr. Bishop the