Cases Of Benign Tumors Research Articles

Surgical Management for Benign Parotid Tumors: Review of a 16-year Experience with 633 Patients

The objective of this study was to analyze the diagnosis and postoperative complications of benign parotid tumors for a series of 633 patients who underwent the same diagnostic methods and operation procedure in a single institute. A series of 633 patients who underwent parotidectomy for benign parotid tumors over a 16-year period was reviewed. There were 345 female and 288 male patients. The site of the tumors was divided among three groups, superficial, deep, and lower pole tumors. The numbers of each type of above tumors were 342, 122, and 169 cases, respectively. The most common pathology of the parotid tumor was a pleomorphic adenoma (372 cases) followed by a Warthin tumor (166 cases). Pleomorphic adenomas and Warthin tumors accounted for 85% of all benign tumors. The accuracy rate of fine needle aspiration cytology (FNAC) for all benign tumors was 71%, 84% for pleomorphic adenomas and 72% for Warthin tumors. Transient facial nerve dysfunction was observed in 130 patients (21%) in 612 cases of primary benign parotid tumors, and only one patient developed a permanent weakness. The incidence of transient facial nerve dysfunction was 18% in superficial tumors, 39% in deep tumors, and 15% in lower pole tumors. Significant risk factors for development of a transient facial palsy were the site of the tumors, the size of the tumors, operation time, and bleeding volume. Among these risk factors, for the site of the tumors, the deep lobe was the most important factor associated with transient facial nerve dysfunction. Transient facial nerve dysfunction recovered within 6 months in 90% of all cases. The accuracy rate of FNAC for benign parotid tumors was 72%. The incidence of transient facial nerve dysfunction in deep tumors was significantly higher compared to that in superficial and lower pole tumors. According to the rate of facial palsy, operation time, and bleeding volume, benign parotid tumor should be divided among three groups, namely superficial, deep, and lower pole tumors.

An audit of the clinicopathological spectrum of benign vascular tumors of female genital tract; with a mini narrative review

Background : Vascular tumors of the female genital tract (FGT) are very rare. The aim of this study was to analyze the spectrum of vascular tumors in FGT and to correlate their clinicopathological features. Materials and Methods : A retrospective study of 15years, including clinical features, imaging studies, gross and microscopic features of 24 cases of benign vascular tumors of FGT were reviewed. The age range was 20–95 years. Presenting complaints were abdominal pain/mass, postcoital bleeding, and vaginal and vulval mass. The duration of symptoms varied from 3months to 10years. A diagnosis of vascular tumor was not considered in any of these on clinical grounds. Results : The most common benign vascular tumor was hemangioma (7cases), followed by chorangioma (5cases). The most common sites of occurrence of these benign tumors were ovary and vulva (8cases each), the rarest site was cervix (1case). The clinical symptom of ovarian vascular tumors was abdominal pain and lump. Among the vascular tumors of ovary, the most common was lymphangioma (4cases) followed by hemangioma (3cases). The least common tumor was angiomyolipoma. The most common vulval tumors were hemangioma and lymphangioma circumscriptum. An unusual case of multiplicity and complexity was observed with 3 neoplasms, one malignant and two benign with additional caseating tuberculous lymphadenitis. Conclusion : Benign vascular tumors in the FGT can present with symptoms similar to gynecological tumors and epithelial malignancies leading to unwarranted radical surgery. The pathological examination is necessary in all such cases to exclude the possibility of malignancy. Angiomyofibroblastoma and aggressive angiomyxoma of the vulva are very rare and both share similar clinical and histopathologic features causing diagnostic problems. KEY WORDS : Angimyolipoma, angiomyofibroblastoma, female genital tract, hemangioma, lymphangioma cisrcumscriptum, vascular tumors

Retroauricular hairline incision を用いた耳下腺良性腫瘍手術

An S-shaped incision is most frequently used for surgeries on benign parotid gland tumors. Surgical procedures using a retroauricular hairline incision (RAHI) for parotid gland tumors was first reported in 2009, but no such case has been reported from Japan. Because RAHI leaves no trace of visible scarring in the face and neck, it is more favorable in terms of cosmetics than an S-shaped incision. We operated on 25 cases of benign parotid gland tumors using RAHI between February 2012 and June 2014. In this report, we give a detailed description of the RAHI procedure, and quantify and compare operative time, bleeding, and complication rate between RAHI procedure and conventional methods. The mean operative time was 150.2 min. Permanent facial paralysis was observed any RAHI case. However, transient facial paralysis was seen in 20.0% RAHI cases, and this value is similar to data reported previously. Because RAHI does not require a preauricular skin incision, unlike S-shaped and facelift incisions, it is difficult to gain an anterosuperior view of the parotid gland. In other words, tumors in the lower pole of the superficial lobe of the parotid gland are the best indication for RAHI. RAHI is a useful approach when performed by surgeons with sufficient experience with standard methods and when surgical indications are accurately determined.

Aneurysmal Bone Cyst in a Phalanx of a Toe

Aneurysmal bone cysts are a benign tumor of the bone, most commonly seen in the tibia, femur, spine and humerus. Cases of aneurysmal bone cysts in the foot, although rare, have been reported several times. To our knowledge, no case of aneurysmal bone cysts in the phalanx of a toe has been reported. We report a case of a primary benign bone tumor in the distal phalanx of the first toe in a 25-year-old male who presented with swelling and pain localized to the distal portion of his left first toe fourteen months ago. En bloc resection was performed, and subsequent microscopy revealed aneurysmal bone cyst.

First time revealed small formations of lungs (under 2 cm in diameter). Dynamic follow-up or surgery?

To develop the treatment algorithm in patients with first time revealed lung lesions smaller than 2 cm. The study included 110 patients with pathological lung lesions with small dimensions who have been treated in the Burdenko Clinic of Faculty Surgery for the period 1997-2013. All patients underwent surgical removal of lung tissue using different surgical approaches: 44 cases of videothoracoscopic resections, 43 video-assisted minithoracotomies, 23 minithoracotomies. There were 25 patients with lung cancer, 38 cases of benign tumours (hamartoma and tuberculoma) and 10 patients with disseminated tuberculosis thar required special treatment. Small pulmonary formations (from 0.5 to 2 cm) can be removed without morphological verification prior to surgery. Optimal surgical approach should be selected depending on the amount and size of formations. Management of solitary lung formation smaller than 0.5 cm that was newly diagnosed by computed tomography should include dynamic follow-up and performance of computed tomography in 3-6-12 months.

Signal intensity-time curve and quantitative dynamic contrast-enhanced magnetic resonance imaging in differentiating neoplasms of uterus

To evaluate signal intensity-time (SI-Time) curve and quantitative dynamic contrast-enhanced 3.0T magnetic resonance imaging in diagnosis and differentiating neoplasm of uterus. A total of 42 cases of uterine neoplasm (20 were malignant and 22 were benign) were evaluated in our study. All cases received dynamic contrast-enhanced scanning on 3.0T MRI. The raw data was processed by Siemens Tissue 4D software and the SI-Time curve was obtained and analyzed. Pharmacokinetic modeling of Tofts with a modeled vascular input function was used for calculating volume parameters: volume transfer constant (Ktrans), reverse volume transfer constant (Kep), the extravascular extracellular space volume per unit volume of tissue (Ve). The correlation of these parameters at each groups were investigated. The SI-Time curve and the data of perfusion parameters between the 2 groups were compared by T test. Among 20 malignant tumors, 12 were cervical carcinoma and 8 were endometrial cancer. Among the benign tumors, 13 were leiomyomas, 3 were endometrial polyp, 3 were endometrial hyperplasia, and 3 were adenomyosis. 59.1% cases of benign tumors belong to Type I curve and 65% cases of malignant tumors belong to Type II curve. There was significant difference in SI-Time curve between benign and malignant tumors (P=0.011). If Type I curve was used as diagnostic criteria for benign tumors, and Type II and III curve were for malignant tumors, the diagnostic sensitivity, specificity, positive predictive value, negative predictive value were 90.0%, 59.1%, 66.7%, and 86.7%, respectively. Ve was 0.477 ± 0.143 in malignant and 0.614 ± 0.146 in control group with significant difference (P=0.004). Ve was 0.477 ± 0.143 in malignant and 0.589 0.176 in benign group with significant difference (P=0.004). Ktrans was (0.178 ± 0.067) min⁻¹ in malignant and (0.263 ± 0.111) min⁻¹ in control group with significant difference (P=0.003). Ktrans was (0.182 ± 0.096) min⁻¹ in benign and (0.263 ± 0.111) min⁻¹ in control group with significant difference (P=0.011). The type of SI-Time curve and perfusion parameters were important for differentiating benign and malignant uterine tumors in dynamic enhanced MRI. These parameters provide a supplement for conventional morphological MR diagnosis.

External bone remodeling after injectable calcium-phosphate cement in benign bone tumor: two cases in the hand

Bone remodeling commonly occurred after fracture and curettage benign bone tumor. A lot of previous articles reported “internal” trabecular bone remodeling. There were no previous clinical reports about “external” cortical bone remodeling. We present here 2 clinical cases of “external” bone remodeling after injectable calcium-phosphate in benign bone tumor in the hand. In two cases of benign bone tumor, we performed complete removal of the tumor and immediate filling of the metacarpal bone with injectable calcium-phosphate cement Arexbone® from the mechanical viewpoint. With respect to the shape of the calcium-phosphate, by using an injection-type, calcium-phosphate is adhered uniformly to the bone cortex by injecting, remodeling has been promoted. After 5 and 8years, both cases were no recurrences, and the shape of the metacarpal looked close to the contralateral side. These findings supposed to be concerned with potential self-healing and self-protection mechanism in human body.

Expression of EphB6 in ovarian serous carcinoma is associated with grade, TNM stage and survival

BackgroundOvarian serous carcinoma (OSC) is the most common ovarian epithelial malignancy. Despite new medical and surgical advances, the overall 5-year survival for OSC remains poor. There is an important need...

Quantitative analysis of cell-free DNA in ovarian cancer.

The aim of the present study was to investigate the association between cell-free DNA (cf-DNA) levels and clinicopathological characteristics of patients with ovarian cancer using a branched DNA (bDNA) technique, and to determine the value of quantitative cf-DNA detection in assisting with the diagnosis of ovarian cancer. Serum specimens were collected from 36 patients with ovarian cancer on days 1, 3 and 7 following surgery, and additional serum samples were also collected from 22 benign ovarian tumor cases, and 19 healthy, non-cancerous ovaries. bDNA techniques were used to detect serum cf-DNA concentrations. All data were analyzed using SPSS version 18.0. The cf-DNA levels were significantly increased in the ovarian cancer group compared with those of the benign ovarian tumor group and healthy ovarian group (P<0.01). Furthermore, cf-DNA levels were significantly increased in stage III and IV ovarian cancer compared with those of stages I and II (P<0.01). In addition, cf-DNA levels were significantly increased on the first day post-surgery (P<0.01), and subsequently demonstrated a gradual decrease. In the ovarian cancer group, the area under the receiver operating characteristic curve of cf-DNA and the sensitivity were 0.917 and 88.9%, respectively, which was higher than those of cancer antigen 125 (0.724, 75%) and human epididymis protein 4 (0.743, 80.6%). There was a correlation between the levels of serum cf-DNA and the occurrence and development of ovarian cancer in the patients evaluated. bDNA techniques possessed higher sensitivity and specificity than other methods for the detection of serum cf-DNA in patients exhibiting ovarian cancer, and bDNA techniques are more useful for detecting cf-DNA than other factors. Thus, the present study demonstrated the potential value for the use of bDNA as an adjuvant diagnostic method for ovarian cancer.

Abstract 2134: Standard immunohistochemistry efficiently screens for ALK rearrangements in differentiated thyroid cancer

Abstract The anaplastic lymphoma kinase (ALK) gene is frequently rearranged in various types of cancer, and is highly responsive to the target therapeutics. We developed a pipeline to detect ALK rearrangement in a large group of Korean thyroid cancer patients. We screened 474 malignant or benign thyroid tumor cases to find ALK fusion. The expression and translocation of the ALK gene were analysed by immunohistochemistry (IHC), fluorescence in situ hybridisation (FISH), and digital multiplexed gene expression (DMGE) using formalin-fixed paraffin embedded tissues. Four cases of ALK rearrangement were screened out of 474 patients by IHC, which were validated by performing FISH for 189 samples. On the other hand, DMGE analysis using Nanostring could detect three out of four IHC positive cases. Two ALK rearrangements were Striatin (STRN)-ALK fusion, identified by 5′ RACE analysis. ALK rearrangements were found exclusively in the BRAF wild type papillary carcinoma. Given the wide availability and accuracy for detecting ectopic ALK expression in the thyroid, we suggest that IHC based screening can be used as a practical method for identifying patients with ALK rearranged differentiated thyroid cancer. Citation Format: Gahee Park, Tae Hyuk Kim, Hae-Ock Lee, Jung Ah Lim, Jae-Kyung Won, Hye Sook Min, Kyu Eun Lee, Do Joon Park, Young Joo Park, Woong-Yang Park. Standard immunohistochemistry efficiently screens for ALK rearrangements in differentiated thyroid cancer. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 2134. doi:10.1158/1538-7445.AM2015-2134

Tumores genitales en las niñas y adolescentes

Presentamos 116 casos de tumores benignos y malignos de la esfera genital de niñas y adolescentes hasta los 17 años, diagnosticados en un lapso de 19 años, de 1952 a 1971 en una sola institución. Estos tumores son muy poco frecuentes a esta edad, pues constituyen sólo el 0.6%; en cambio, son mucho más frecuentes en la mujer adulta, después de los 17 años, grupo que forma el 99.4% de nuestra casuística. De los 116 casos algo más de la tercera parte han correspondido al grupo de los malignos y casi las dos terceras partes han sido de naturaleza benigna. Los 40 casos de tumores malignos de nuestr casuística, representan la mas grande resportada hasta ahora en series individuales. Los tumores malignos más frecuentes en la niñez y adolescencia son los de localización ovárica, que representana más de las dos terceras partes del total, siguiéndole la localización vaginal. Ponemos énfasis en ciertos principios ginecológicos que guían al cirujano en el manejo de los tumores benignos de ovario en niñas y adolescentes. Nuestra casuística de cáncer ginecológico está constituída por 13,558 casos de neoplasias malignas en mujeres adultas, por solo 40 casos en niñas y adolescentes, lo que equivale en porcentaje al 99.8% y 0.2% respectivamente. Es interesante anotar que la edad promedio para los tumores malignos de la vulva, útero y ovario fluctúa alrededor de los 12 años, en cambio es mucho menor, 5.4 años para la localización vaginal. Presentamos un caso de hemangiopericitoma maligno de la vulva, que no ha sido reportado anteriormente.

Vascular tumors of the external auditory canal: three case reports and a review of the literature.

BackgroundBenign vascular tumors are frequently found in the head and neck, however, such tumors of the external auditory canal are extremely rare. We report three cases of benign vascular tumors limited to the external auditory canal.Case descriptionA 50-year-old woman was diagnosed during an episode of ear fullness and hearing loss. A 10-year-old boy consulted our department about an episode of recurrent otorrhagia. A 20-year-old man found a bulge of his external auditory canal by chance. Complete surgical resection was performed for the first patient. The second patient underwent electro-coagulation of the lesion. In the third patient, to exclude the possibility of a malignant tumor, a biopsy was performed under local anesthesia. Histopathological analysis demonstrated the characteristic of vascular tumors. The lesion showed remarkable reduction during his treatment with antibiotics and cleaning. He remains under careful observation.Discussion and evaluationIn diagnosis, there is sometimes confusion between vascular tumors and malformations. Generally, vascular malformations can be differentiated from vascular tumors since they are present at birth and are generally stable.ConclusionDecision making about treatment of benign vascular tumors is sometimes confusing because of the difficulty in diagnosis. We performed biopsy for only one of our three cases because we regard that informal biopsy should not be conducted for lesions with difficult hemostic conditions and locations.Electronic supplementary materialThe online version of this article (doi:10.1186/s40064-015-1113-5) contains supplementary material, which is available to authorized users.

A novel biomarker ARMc8 promotes the malignant progression of ovarian cancer.

Ovarian cancer is the most lethal gynecologic malignancy worldwide, and the survival rates have remained low in spite of medical advancements. More research is dedicated to the identification of novel biomarkers for this deadly disease. The association between ARMc8 and ovarian cancer remained unraveled. In this study, immunohistochemical staining was used to examine ARMc8 expression in 247 cases of ovarian cancer, 19 cases of borderline ovarian tumors, 41 cases of benign ovarian tumors, and 9 cases of normal ovarian tissues. It was shown that ARMc8 was predominantly located in the cytoplasm of tumor cells, and its expression was up-regulated in the ovarian cancer (61.9%) and the borderline ovarian tumor tissues (57.9%), in comparison with the benign ovarian tumors (12.2%; P < .05) and the normal ovarian tissues (11.1%; P < .05). In ovarian cancer, ARMc8 expression was closely related to International Federation of Gynecology and Obstetrics stages (P = .002), histology grade (P < .001), lymph node metastasis (P = .008), and poor prognosis (P < .001). Univariate and multivariate Cox analyses revealed that ARMc8 expression was an independent prognostic factor for ovarian cancer (P = .039 and P = .005). In addition, ARMc8 could promote the invasion and migration of ovarian cancer cells. Overexpressing ARMc8 enhanced the invasion and metastasis capacity of ARMc8-low Cavo-3 cells (P < .001), whereas interfering ARMc8 significantly reduced cell invasion and metastasis in ARMc8-high SK-OV-3 cells (P < .001). Furthermore, ARMc8 could up-regulate matrix metalloproteinase-7 and snail and down-regulate α-catenin, p120ctn, and E-cadherin. Collectively, ARMc8 may enhance the invasion and metastasis of ovarian cancer cells and likely to become a potential therapeutic target for ovarian cancer.

Diagnostic Utility of Diffusion-weighted Magnetic Resonance Imaging in Differentiating Small Solid Renal Tumors (≤ 4 cm) at 3.0T Magnetic Resonance Imaging.

Background:The aim of this study was to assess the performance of apparent diffusion coefficient (ADC) measurement obtained with diffusion-weighted magnetic resonance imaging (DW-MRI) to distinguish renal cell carcinomas (RCCs) from small benign solid renal tumors (≤4 cm).Methods:In this cross-sectional study, 49 consecutive patients with histopathologically confirmed small solid renal tumors, and seven healthy volunteers were imaged using nonenhanced MRI and DW-MRI. The ADC map was calculated using the b values of 0, 50, 400, and 600 s/mm2 and values compared via the Kruskal–Wallis and Mann–Whitney tests. The utility of ADC for differentiating RCCs and benign lesions was assessed using a receiver operating characteristic curve. Multiple nonenhanced MRI features were analyzed by Logistic regression.Results:The tumors consisted of 33 cases of clear-cell RCCs (ccRCCs) and 16 cases of benign tumors, including 14 cases of minimal fat angiomyolipomas and 2 cases of oncocytomas. The ADCs showed significant differences among benign tumors ([0.90 ± 0.52] × 10−3 mm2/s), ccRCCs ([1.53 ± 0.31] × 10−3 mm2/s) and the normal renal parenchyma ([2.22 ± 0.12] × 10−3 mm2/s) (P < 0.001). Moreover, there was statistically significant difference between high and low-grade ccRCCs (P = 0.004). Using a cut-off ADC of 1.36 × 10−3 mm2/s, DW-MRI resulted in an area under the curve (AUC), sensitivity, and specificity equal to 0.839, 75.8%, and 87.5%, respectively. Nonenhanced MRI alone and the combination of imaging methods led to an AUC, sensitivity and specificity equal to 0.919, 93.9%, and 81.2%, 0.998, 97%, and 100%, respectively. The Logistic regression showed that the location of the center of the tumor (inside the contour of the kidney) and appearance of stiff blood vessel were significantly helpful for diagnosing ccRCCs.Conclusions:DW-MRI has potential in distinguishing ccRCCs from benign lesions in human small solid renal tumors (≤4 cm), and in increasing the accuracy for diagnosing ccRCCs when combined with nonenhanced MRI.

Endoscope-assisted extracapsular dissection of benign parotid tumors using hairline incision.

This study evaluated the feasibility of endoscopic-assisted extracapsular dissection of benign parotid tumors using only hairline incision. Endoscope-assisted extracapsular dissection via only hairline incision was performed in 18 cases (5 men and 13 women) of benign parotid gland tumor (pleomorphic adenoma in 4 cases, Warthin's tumor in 14 cases). All 18 operations were successfully performed and no conversions to conventional open resection were necessary. One patient had transient facial paresis and recovered within 1 month. The duration of the procedure was 82.5 ± 18.5 minutes. Endoscope-assisted extracapsular dissection using only hairline incision is a feasible method for treatment of benign parotid tumors. The main advantage of this procedure is that the operative scar is concealed in the hairline area.

Strain elastography features of epidermoid tumours in superficial soft tissue: differences from other benign soft-tissue tumours and malignant tumours.

We evaluated ultrasonographic features of superficial epidermoid tumour with a focus on strain elastography (SE) features that will help in the differential diagnosis of epidermoid tumour from other benign and malignant soft-tissue tumours. We retrospectively evaluated ultrasonographic and SE data of 103 surgically confirmed superficial soft-tissue tumours and tumour-like lesions: 29 cases of epidermoid tumour, 46 cases of other benign tumours and 28 cases of malignant tumour. SE and B-mode imaging were performed at the same time. SE characteristics were assigned into four grades (1-4) according to their elasticity. Interobserver agreement for the four SE scores between the two radiologists was analysed using kappa statistics. We classified each SE finding as a hard lesion (SE Score 3-4) or soft lesion (SE Score 1-2) and compared these findings using the χ(2) test to identify whether a significant difference in mass hardness existed among epidermoid tumour, other benign tumour and malignant tumour. Overall interobserver agreement according to the four SE scores was moderate (κ = 0.540), and overall agreement for the hardness [soft (Score 1-2) or hard (Score 3-4)] was almost perfect (κ = 0.825). Malignant tumours showed higher SE scores (3-4, hard nature) than did epidermoid tumour or other benign soft-tissue tumours. There were no differences in SE score between epidermoid tumour and other benign tumours. Superficial epidermoid tumour exhibits a softer nature than does malignant tumour but does not have a different SE pattern from other benign tumours. SE features of epidermoid tumour might be helpful in differentiating from other benign and malignant tumours.

Extended curettage and adjuvant therapy for benign tumors of the talus

PurposeBenign tumors of the talus are rare, and their management is controversial. Recent efforts have extended the safety margin of intralesional excision and curettage by chemical and physical means. Cryotherapy as adjuvant therapy is associated with risks of local wound and bony complications (delayed healing, potential for pathological fractures). MethodsWe retrospectively reviewed six cases of benign talar tumors (three giant cell tumors, two aneurysmal bone cysts, one osteoblastoma) treated by extended curettage and adjuvant cryotherapy. Talar bone stock was restored by bone grafting the residual cavity with fibular strut grafts and/or cancellous bone grafts. Patients were followed for a mean of 40 months. ResultsAt latest follow-up, each patient had a mobile painless ankle and good functional outcome. No patient experienced recurrence or complications related to cryotherapy. ConclusionsIntralesional extended curettage with bone grafting and cryotherapy is a successful, safe, and efficient treatment of benign tumors of the talus.

Hamartome neuromusculaire de l’orbite : rapport d’un cas et discussion de la place de corticothérapie dans le traitement

Neuromuscular hamartoma, also known as neuromuscular choristoma or benign triton tumor, is a rare benign tumor of well-differentiated striated muscle fibers mixed with peripheral nerve fibers. According to our research, this is the sixth case of benign triton tumor of the trigeminal nerve and the third case of isolated orbital location reported in the world literature. To report a rare case of orbital neuromuscular hamartoma and discuss the role of corticosteroids in the treatment of these lesions for which surgical excision is often difficult. A 47-year-old woman, with a history of tuberculous lymphadenitis treated in 2006, presented with a clinical scenario of inflammatory orbitopathy without loss of visual acuity progressing over 20 days. MRI showed a lesion centered on the soft tissues of the infero-lateral right orbit. A biopsy was performed, showing neuromuscular hamartoma on histology. The patient was put on a tapering dose of corticosteroids with clear clinical and anatomical improvement. Orbital CT follow-up was obtained two months after discontinuation of treatment, confirming the disappearance of the tumor mass. Hamartoma of the orbit is a very rare entity and may clinically simulate malignant neoplasms; the diagnosis is histologic. Given the difficulties encountered in the resection of these tumors, we believe that corticosteroids might be proposed as an alternative treatment that could modulate inflammation and bring about regression or disappearance of the tumor.

A Study on Expression of P53 in Surface Epithelial Ovarian Tumours

Aims and Objectives: (1) To perform and interpret p53 immunostaining on the diagnosed malignant surface epithelial ovarian tumours. (2) To correlate expression of p53 with histological type of malignancy. Materials and Methods: A 2-year prospective study was done i.e., from October 2011 to September 2013 on ‘A study on expression of p53 in surface epithelial ovarian tumours’ in MGM Hospital, Warangal. All the ovarian surface epithelial tumour specimens, received in the pathology department during this period were considered. Results: A total of 121 cases were studied, out of which benign tumours were the most common (64.4%), followed by malignancy (25.6%) and 12 cases(10%) of borderline malignancy. Most of the benign tumours were unilateral; the cases that showed bilateral involvement were mostly malignant. The maximum number of cases in the present study was seen in the age group of 31–60 year. The youngest patient was 16 year old and the oldest was 68 year old. Serous cyst adenoma was the most common neoplasm found and accounted for 53 cases (43.8%), followed by mucinous cystadenoma, which accounted for 21 cases (17.3%).Nine cases of serous cystadenofibroma (7.43%), 3 borderline serous tumours (2.47%) and 11 serous cystadenocarcinoma (9%) were found in the present study. Out of the 44 mucinous tumours, 21 were benign (17.3%), 3 were of borderline malignancy (2.47%) and 20 were malignant (16.5%). One case of mucinous cystadenocarcinoma was found to be associated with adenocarcinoma of ascending colon. One case of benign Brenner tumour was also found in the present study. The rate of p53 abnormalities varies with histological type, grade and stage of the tumour. P53 expression was more in malignant serous tumours as compared to the malignant mucinous tumours.

Cosmetology Incision in Treatment of Benign Tumor of Breast: A Report of 1000 Cases

Objective: To explore the selection of the best incision for operative treatment of benign breast tumor. Methods: The clinical data of 1000 cases of benign breast tumor operated by cosmetology incision were retrospectively analyzed. Results: All patients underwent tumor resection and were satisfied with the incision. Conclusions: Benign breast tumor can be excised through cosmetology incision, and no obvious scar leaves behind, so it can satisfy the cosmetic requirement of many patients.