Using the molecular dynamics method the migration of vacancies in the depleted zones of the alpha-iron crystallite, initiated in the place, where the cascade of atom—atom collisions passes, have been investigated within the temperature range 600–1200 K. The average volume concentration of the vacancy sites C ̄ v in the depleted zone (DZ) was a varying parameter and was specified within the range from 5 to 15 at% The frequencies of the vacancy jumps in DZ were calculated for different temperatures and C ̄ v values. The jump frequency satisfied the Arrhenius dependence, which made it possible to estimate the effective energy of vacancy migration in the depleted zone E v m. The E v m values for C ̄ v = 5, 10 and 15 at% were found to be equal to 0.23 eV, 0. respectively, which is by 3–5 times lower than the energy of migration of an isolated monovacancy (0.64 eV) also calculated by the molecular dynamics method. The decrease in the energy of vacancy migration in DZ cannot be accounted for by decrease in the static potential barrier of vacancy migration in DZ since its change in DZ did not exceed 10–15 at% as compared with the static barrier of the isolated monovacancy. The phenomenon of accelerated mobility of vacancies in DZ is the consequence of the mutual vacancy effect through perturbation of modes responsible for the diffusion jump of defects.