In robust design (RD) modeling, the response surface methodology (RSM) based on the least-squares method (LSM) is a useful statistical tool for estimating functional relationships between input factors and their associated output responses. Neural network (NN)-based models provide an alternative means of executing input-output functions without the assumptions necessary with LSM-based RSM. However, current NN-based estimation methods do not always provide suitable response functions. Thus, there is room for improvement in the realm of RD modeling. In this study, a new NN-based RD modeling procedure is proposed to obtain the process mean and standard deviation response functions. Second, RD modeling methods based on the feed-forward back-propagation neural network (FFNN), cascade-forward back-propagation neural network (CFNN), and radial basis function network (RBFN) are proposed. Third, two simulation studies are conducted using a given true function to verify the proposed three methods. Fourth, a case study is examined to illustrate the potential of the proposed approach. In conclusion, a comparative analysis of the three feed-forward NN structure-based modeling methods and conventional LSM-based RSM proposed in this study showed that the proposed methods were significantly lower in the expected quality loss (EQL) and various variability indicators.