Consumption Of Carrots Research Articles

Pelatihan Pembuatan Ice Cream Wortel untuk Komunitas PKK di Desa Wonolelo Magelang

Carrots are one of the abundant agricultural products in Wonolelo Village, Magelang. This type of root vegetable contains various nutrients such as Vitamin A, β-carotene, and fiber, which are beneficial for eye health and boosting the immune system against infections. The consumption of fresh carrots is less favored by the community, especially children, so carrot-based processed products in the form of healthy beverages like carrot ice cream can be an attractive and healthy alternative for consumption. The purpose of this activity is to explore the processing of carrots to maximize harvests and optimize the selling value and functionality of carrots as a healthy and appealing product for children. This training uses practical methods, allowing participants to practice and directly process carrots into ice cream. The conclusion of this activity is that it provides insight into carrot processing innovations for the PKK mothers in Wonolelo Village, specifically on how to turn carrots into ice cream, thereby increasing the selling value of carrots, which impacts the welfare of the community, especially carrot farmers.

Comparison of skin prick test and prick-to-prick test with fruits and vegetables in the diagnosis of food allergy.

Prick-to-prick (PTP) test with fresh food is accepted as a reliable tool for measuring sensitization to fruits and vegetables. Not all fruits and vegetables are available throughout the year. The objective of this study was to investigate whether skin prick test (SPT) performed with frozen juice of fruits and vegetables (FJFV) is a good alternative to PTP tests performed with fresh fruits and vegetables (FFV). Adult patients suspected of having a food allergy to fruits and/or vegetables were included. A questionnaire was used to score symptoms after consumption of apple, kiwi, peach, tomato, and carrot. SPTs with FJFV, and PTP tests with FFV were performed. Intra-class correlation coefficients (ICC) between the SPT and PTP test results were calculated. The sensitivity and specificity of both diagnostic tests towards food allergen specific symptoms (FASS) were calculated. Thirty-six patients were included. FASS was positive in 75% for apple, 53% for kiwi, 44% for peach, 25% for tomato, and 22% for carrot. ICC between SPT and PTP test results were moderate for apple (0.72) and kiwi (0.71), strong for peach (0.75) and tomato (0.89), and very strong for carrot (0.94). Sensitivity was equal for the SPT and PTP tests for apple (0.93), peach (0.81), and carrot (1.00), and comparable for kiwi (0.50 resp. 0.70), and tomato (0.44 resp. 0.56). Specificity was equal for apple (0.33), peach (0.15), and carrot (0.41), and comparable for kiwi (0.29 resp. 0.21) and tomato (0.80 resp. 0.72). Results of SPT with FJFV and PTP test with FFV are comparable. SPT with FJFV is a good alternative in the daily practice of the allergists.

Relationship between carrot intake, dietary/circulating α-carotene and cancer risk: A systematic review and meta-analysis of prospective observational studies

Carrot consumption reduces tumour development in several animal models. The constituent alpha- carotene has not by itself shown anti-cancer properties, however carrots typically provide >85% of alpha-carotene dietary intake(1-3), justifying its use as an indicator of carrot intake(3). We conducted a meta-analysis to investigate inverse associations of carrot/dietary α-carotene intakes and cancer risk, and to quantify potential dose–response relationships.PubMed, Cochrane Library, Web of Science, Scopus, EBSCO, and JSTOR were searched (from database inception to August 2021) for studies reporting risk estimates with 95% CIs for the relationship between carrot intake or α-carotene and cancer risk. Meta-analyses were conducted using a random-effects model comparing highest and lowest intakes to estimate summary risk estimates (RRs).Of 80 prospective studies included, 15 (with 25738 cases) reported data on carrot intake, 35 (26262 cases) on dietary α-carotene intake and 30 (9331 cases) on plasma α-carotene levels. A significantly (P<0.01) decreased risk of overall cancer was associated with carrot intake (RR = 0·90), dietary α- carotene intake (RR = 0·90) and plasma α-carotene (RR = 0·80). In addition, both carrot intake and plasma α-carotene level manifested linear dose-response relationships with cancer risk, with increasing carrot intake reaching 20% risk reduction at 5 servings (400g) per week (p < 0·0001),and successive 50μg/L increments in plasma α-carotene associated with 11% risk reduction (p < 0·0058).Carrot consumption is robustly associated with decreased cancer risk. Carrot consumption should be encouraged, and the causal mechanisms further investigated.

Chemical And Organoleptic Quality Of Suction Pudding With Variations In The Type And Concentration Of Carrot Extract (Daucus carota L.)

Carrots are one type of vegetable that is rich in vitamin A. In order to increase carrot consumption, it is necessary to diversify carrot-based preparations, among others, by adding carrots to the pudding suction. This study aims to determine the effect of the interaction of the type and concentration of wotel extract on the chemical and organoleptic quality of lipo pudding as functional food. The research method used is experimental laboratory with Complete Random Design (RAL) research design which is arranged factorially with 2 (two) factors. The first factor is the type of carrot extract, namely boiled carrot extract and fresh carrot extract. The second factor is the difference in carrot extract concentration, which is 7%, 10% and 13% carrot extract. Each treatment factor was repeated 3 (three) times resulting in 18 trials. Observational variables include β-carotene tests, crude fiber tests, reduction sugar tests, and organoleptic tests. Based on the results of the study showed that the interaction between different types and carrot extracts had no real effect on β-carotene levels, crude fiber levels, sugar reduction levels. The best treatment in this study was the F2B treatment, namely suction pudding with the addition of fresh carrot extract with a concentration of 10% with the highest Yield Value (NH) of 0.87. The criteria for the parameters of the study were β-carotene content = 983.0 ppm, crude fiber content = 2.1%, reduced sugar content = 14.37%, color = 5.05 (somewhat like), taste = 5.07 (somewhat like), aroma = 4.67 (somewhat like), and chewiness = 4.71 (somewhat like).

Changes in Intake and Major Food Sources of Carotenoids among U.S. Adults between 2009-2018.

Large epidemiologic studies suggest that diets rich in total or specific carotenoids are associated with a reduced risk of many chronic diseases. However, there are few studies characterizing trends in dietary carotenoid sources and intake among subgroups of the US adult population in the previous decade. This study aimed to assess these trends using data from 22,339 adults who participated in NHANES 2009-2018 cycles. Carotenoid intake and major food sources were calculated by linking food consumption data from the 24 h diet recall to an FNDDS 2009-2018 and the USDA's National Nutrient Database for Standard Reference (Release 28). Among US adults, mean (SE) dietary carotenoid intake was 9687.1 (158.0) mcg/day, and total intake was highest in men, non-smokers, moderate alcohol consumers, supplement users, and those with normal BMI, a PIR ≥ 1.85, and whose physical activity level was considered vigorous (p < 0.05). Carotenoid intake has gradually decreased over the past decade (p-trend: 0.097), especially among White adults (p-trend < 0.05), males (p-trend: 0.062), and those with a PIR of 1.0-1.3 (p-trend: 0.051), as have estimated rates of vitamin A adequacy. Tomatoes, carrots, and spinach were major food sources of carotenoids, and consumption of carrots and tomatoes decreased, while the consumption of lettuce, spinach, and salsa increased from 2009 to 2018. Our results warrant further studies investigating the consequences of the decreased tendencies of carotenoid intake on chronic disease risk, especially focusing on population subgroups exhibiting low or decreasing trends of carotenoid intake status.

Proximate composition and prevalence and exposure assessment of aflatoxins intake through consumption of fresh carrot and processed marketed carrot products in South Punjab, Pakistan

Carrot (Daucus carota L.) is a nutrient-rich vegetable that is widely cultivated and consumed in Pakistan in both raw and processed form. Data on the proximate composition and natural occurrence of aflatoxins (AFs) in carrots and marketed carrot products is lacking in Pakistan and the risk exposure of AF has not been characterised before. Thus, the current study was designed to know the frequently consumed carrot products with per capita consumption, and risk assessment of AF through these products in various regions of South Punjab Pakistan. A survey was conducted with 125 respondents and appeared that raw carrot, fresh carrot juice, gajrella and pickle are the most frequently consumed marketed carrot products with per capita consumption i.e. 62.5, 46.6, 16.2 and 14.5 gday-1, respectively. Proximate analysis revealed that carrot root and processed carrot products contained 9.65–98.2% moisture, 0.23–0.60% ash, 6.2–14.1% carbohydrates, 0.31–0.80% protein, 0.40–3.7% fat and 1.4–4.20% fibre. AF analysis revealed that 36.67% of samples were contaminated with TAF. Thirty-five (35%) percent of samples were tainted with aflatoxin B1, and 13.33% of samples were contaminated with aflatoxin B2. All the samples of carrot root, fresh carrot juice and gajrella contained TAF levels less than the maximum limit (ML) (2 ppb) assigned by the European Union (EU). However, the entire AFB1 positive samples of carrot pickle contained AFB1 levels of more than 2 ppb exceeding the ML. Furthermore, daily dietary exposure of TAFs ranged from 0.11 to 1.27 ng/kg of body weight per day which relatively exceeds the permissible limit of 1 ng/kg of body weight per day as defined by the Joint FAO/WHO Expert Committee on Food Additives. This is the first prevalence and risk assessment report of AF in marketed processed carrot products in Pakistan. These baseline data are an initial step in the effort to deal with this significant food safety issue and the establishment of legislation for AF in marketed products is needed in Pakistan.

Health Risk and Quality Assessment of Vegetables Cultivated on Soils from a Heavily Polluted Old Mining Area.

Three garden vegetables-radish, carrot and lettuce-were cultivated in a pot experiment using two soils from the Příbram area polluted mainly by cadmium (Cd), zinc (Zn), lead (Pb) and chromium (Cr). The soils of the Příbram district, Czech Republic, are heavily polluted as a result of the atmospheric deposition of toxic elements originating from historic lead-silver mining and smelting activities. The results showed that lettuce absorbed the highest amounts of toxic elements (Cd 28 and 30, Cr 12 and 13, Zn 92 and 205 mg·kg-1 DW), except Pb, which was higher in radish (30 and 49 mg·kg-1 DW). Changes in macronutrient contents in edible parts were not found, except for sulfur. A higher total free amino acids (fAAs) accumulation was shown in all vegetables in more contaminated soil, with the highest fAA content being in radish. A group of essential fAAs reached 7-24% of total fAAs in vegetables. The risk to human health was characterized using the target hazard quotient and total hazard index (HI). The cumulative effect of the consumption of vegetables with HI > 1 showed possible non-carcinogenic health effects for lettuce and carrot. HI decreased in the order Cd > Pb > Cr > Zn. The carcinogenic risk of toxic elements decreased in the order Cd > Cr > Pb (0.00054, 0.00026, 0.00003). These values showed a carcinogenic risk from the consumption of lettuce and carrot and confirmed that the adult population of the studied area is at high risk if lettuce and carrot cultivated in this area are consumed daily.

Determination of the Selected Heavy Metal Content and Its Associated Health Risks in Selected Vegetables Marketed in Bahir Dar Town, Northwest Ethiopia

Introduction. Fresh vegetables are of a great value and the most common foods in the human diet around the world. They contain minerals, vitamins, antioxidants, antimetabolites, protein, carbohydrates, and water. However, they are a major source of heavy metals, which contain both essential and toxic heavy metals over a wide range of concentrations. The study sites serve as a regional commercial center, where vegetables such as cabbages, onions, carrots, potatoes, beetroots, lettuce, and tomatoes were irrigated year round and sold to consumers. The aim of the study was to determine the level of cadmium, chromium, copper, and lead and to estimate the health risks associated with their daily intake of vegetables marketed in Bahir Dar town, Northwest Ethiopia. Methods. The concentrations of copper (Cu), chromium (Cr), cadmium (Cd), and lead (Pb) were determined, and their health risks were estimated using estimated daily intake (EDI), target hazard quotient (THQ), hazard index (HI), and target cancer risk (TCR) for selected heavy metals by using flame atomic absorption spectrometry. A total of 5 kg composite samples for each type of vegetable were collected by simple random sampling from an open market in Bahir Dar town, Northwest Ethiopia, and subsamples (1.25 kg) were digested via the wet digestion method. Results. The average concentrations of Cr and Cu in all selected vegetables were lower than the maximum limit of expected values. However, the concentration (mg.kg−1) of Pb in carrots, potatoes, and beetroots exceeded the safe limit of 0.3 mg·kg−1 set by the FAO/WHO and the concentration of Cd (mg·kg−1) in carrots, which is higher than the FAO/WHO limit, 0.2 mg·kg−1, in dry weight. The health index (HI) values (mg·kg−1 day−1) of all vegetables except carrots were lower than one. The TCR values for Pb, Cd, and Cr in all vegetables exceeded the US-EPA recommended threshold risk limit, but the TCR value of carrot was above the moderate risk limit (&gt;1 × 10−3) set by the US-EPA. Conclusion. This study indicated that the concentration level of lead and cadmium in potatoes, onions, carrots, and beetroots marketed in Bahir Dar town is not safe for use by the local community. The consumption of carrots in the study area may cause both noncancerous and cancerous health risks. Therefore, regular monitoring of these toxic metals in vegetables should be carried out to prevent heavy metal toxicity associated with the consumption of those vegetables marketed in Bahir Dar town, Ethiopia.

Salad Days: Pairwise Gene Edits Food to Topple Nutrition Barriers

Salad Days: Pairwise Gene Edits Food to Topple Nutrition Barriers

Non-carcinogenic and carcinogenic risk assessment of some heavy metals in carrots selected from Wudil, Kano, Nigeria

Fruits and vegetables contaminated with heavy metals can pose health risks to humans. Noncarcinogenic and carcinogenic risks of some metals (Cu, Cd, Cr, Pb, and Ni) in carrots cultivated in Wudil, Kano, Nigeria was investigated by calculating the chronic daily intake (CDI), target hazard quotient (THQ), hazard index (HI), and carcinogenic risk (CR) of the metals. The mean concentrations of the metals were in the following decreasing order: Cu&gt;Cr&gt;Ni&gt;Pb&gt;Cd. The levels of all the metals were below the maximum tolerable limit set by FAO/WHO. The THQ for the heavy metals were all less than one (THQ &lt; 1), showing that these metals did not constitute a noncarcinogenic risk to the population through the consumption of carrots. The percentage contributions of the metals to the total non-carcinogenic risk were in the following order: Cr&gt;Pb&gt;Cu&gt;Cd&gt;Ni. Cr was the major contributor to the total non-carcinogenic risk and accounted for 57.61% of the total risk, while Pb, Cu, Cd, and Ni contributed 15.64%, 12.76%, 7.41%, and 6.58% respectively. The CR were all below the upper limit of 1×10-4, suggesting that lifetime exposure to these metals through the consumption of carrots did not pose a cancer risk to the population. The levels of the investigated metals in carrots in the area did not pose any risk to the consumers. However, there is a need to monitor the metals on regular basis to ensure the safety of the consumers.

Root Vegetables-Composition, Health Effects, and Contaminants.

Root vegetables are known all over the world, but they are being less and less consumed by individuals. The main purpose of this article was to summarize the benefits, health effects, and threats associated with the consumption of carrot, celery, parsley, beetroot, radish, turnip, and horseradish. They are characterized by high nutritional value due to their richness in dietary fiber, vitamins, and minerals. One of their most important features is their high content of bioactive compounds, such as polyphenols, phenols, flavonoids, and vitamin C. These compounds are responsible for antioxidant potential. Comparison of their antioxidant effects is difficult due to the lack of standardization among methods used for their assessment. Therefore, there is a need for a reference method that would allow for correct interpretation. Moreover, root vegetables are characterized by several health-promoting effects, including the regulation of metabolic parameters (glucose level, lipid profile, and blood pressure), antioxidant potential, prebiotic function, and anti-cancer properties. However, due to the type of cultivation, root vegetables are vulnerable to contaminants from the soil, such as toxic metals (lead and cadmium), pesticides, pharmaceutical residues, microplastics, and nitrates. Regardless, the low levels of toxic substances present in root vegetables do not pose health risks to the average consumer.

Association of Dietary Carrot/Carotene Intakes With Colorectal Cancer Incidence and Mortality in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.

Background:The evidence of dietary carrot/carotene intake's effect on the association with colorectal cancer (CRC) risk is conflicted. We sought to examine the association of carrot/carotene intake with CRC incidence and mortality in the Prostate, Lung, Colorectal, and Ovarian Cancer (PLCO) Screening cohort.MethodsIn all, 101,680 participants were enrolled between November 1993 and July 2001 from the PLCO cohort. We employed the multivariable Cox regression analyses to estimate the hazard ratios and 95% confidence interval. Subgroup analyses and interaction tests were performed to examine the potential effect modifiers. We further applied the generalized additive model to explore the non-linear trend of the exposure to cancer-related outcomes.ResultsA total of 1,100 CRC cases and 443 cancer-related deaths were documented. We noted that the 4th quintile of dietary carrot intakes was associated with a 21% lower risk of CRC incidence, compared with the lowest quintile group (full-adjusted HRquintile4vs.quintile1 = 0.79, 95%CI = 0.65–0.97, p for trend = 0.05), while the adjusted-HR was 0.95 (95%CI = 0.89–1.02) with per SD increment of carrot intakes, and no statistically significant associations were detected between dietary α-, and β-carotene intake and CRC incidence. There were no statistically significant associations observed between carrot/carotene intakes and CRC mortality. Furthermore, there were no non-linear dose-response relationships between dietary carrot, α-, and β-carotene intake and CRC incidence and mortality (all pnonlinearity > 0.05). Of note, smoking status as a modifier on the association of dietary carrot intakes with CRC incidence but not mortality was observed.ConclusionsIn summary, this large U.S. prospective cohort study indicated that a moderate consumption of carrots was associated with a lower CRC incidence, which suggested that a certain dose-range of carrots consumed might contribute to a potential cancer-prevention effect, not the more the better.

An Analysis of Health Benefits of Carrot

carrot (Daucus carota subsp. sativus) is root vegetation that available in diversity of colors, comprising purple, black, red, white, &amp; yellow. Carrots include carotenids, flavonoid, polyacetylens, vitamins, &amp; minerals, all which provide diversity of nutritional &amp; health advantages. Carotenoids, polyphenols, &amp; vitamins found in carrots function as antioxidants, anticarcinogens, &amp; immune enhancers, proving ancient saying that carrots are excellent for eyes. Carrot has shown to have antidiabetic, cholesterol &amp; cardiac disease reducing, antihypertensive, hepatoprotective, renoprotective, &amp; wound healing properties. Carrot seed extracts have cardio- &amp; hepatoprotective, antibacterial, antifungal, antiinflammatory, &amp; analgesic properties. All of se topics are covered in this review essay. Carrots are important tuber crop that is high in biochemical elements like carotenoid and soluble fiber, as well as variety of other functional elements with wellness properties.. Carrot consumption is gradually rising as a result of its recognized as a valuable source of natural antioxidants with anticancer properties. Apart from being utilized in salads &amp; curries in India, carrot roots may be professionally processed into nutritionally rich processed goods like as juice, concentrate, dry powder, tinned, preserve, c&amp;y, pickle, &amp; gazrailla. Carrot pomace, which contains approximately 50% -carotene, may be used to enhance goods such as cake, bread, &amp; biscuits, as well as to make a diversity of useful products. nutritional content, health-promoting phytonutrients, functional characteristics, product creation, &amp; by-products usage of carrot &amp; carrot pomace, as well as ir prospective application, are all highlighted in this study.

Stabilising fluoride in contaminated soils with monocalcium phosphate and municipal solid waste compost: microbial, biochemical and plant growth impact.

This study evaluated the influence of a municipal solid waste compost (MSWC) and monocalcium phosphate (MCP), alone or combined, on the mobility, toxicity, bioavailability and health risk of fluoride (1000mg F-·kg-1) in an artificially polluted soil (pH 7.85). The addition of MCP (0.2% w/w) and MSWC (1% w/w) (alone and combined) to the contaminated soil reduced water-soluble (e.g. by more than 50% in MCP and MCP + MSWC-treated soils) and exchangeable F- fractions and increased the residual one. The addition of MSWC and MSWC + MCP to the contaminated soil significantly increased microbial biomass C (SMB-C; 1.3-3.6-fold) while all treatments increased the abundance of culturable heterotrophic bacteria (up to twofold in MSWC + MCP). Overall, dehydrogenase, β-glucosidase, urease and phosphomonoesterase activities were enhanced in treated soils and positively correlated with SMB-C, but not with labile F-. All treatments increased carrot yield (up to 3.4-fold in MSWC + MCP), while bean growth was significantly enhanced only by MCP and MCP + MSWC (~ twofold). The opposite trend applied for F- uptake which was especially reduced in the edible part of carrot after soil amendment. A limited influence of MCP and MSWC on hazard quotient (HQ), due to bean and carrot consumption, was also recorded (i.e. HQ generally > 1). Results suggest that MCP and MSWC can be used in the recovery of soil chemical, microbial and biochemical status of F-rich agricultural soils. They also indicate that the bean and carrot cultivars employed in this study are likely unsuitable in such soils due to high F- uptake in edible parts.

The Effects of Seed Extract of Carrot on Memory, Nerve Conduction Velocity, and Serum Thyroxin in Rats.

Background:Thyroid hormones are essential to maintain the tissue's metabolism throughout the life. Thyroid hormones exert their effects on physiology and almost all body functions. Carrot is a rich source of iodine and carotenoids that can interfere in the synthesis of thyroid hormones.Materials and Methods:The present study was designed to investigate the effects of carrot consumption on T4 levels and its effect on memory, nerve conduction velocity (NCV), animal weight, and finally, on water and food intake in Wistar rats. In this study, 24 male rats were used and divided into three groups: Control, Ca 200 mg/kg, and Ca 400 mg/kg.Results:The results indicated that carrot consumption at Ca 200 mg/kg treated group increased the level of serum T4 and induced hyperthyroidism. Animal weight in both treated groups did not change compared to the control group (P > 0.05). Water and food consumption, and the level of T4 in Ca 200 mg/kg group increased when compared to the control group (P < 0.05). NCV in both treated groups was not significantly different in comparison with the control group (P > 0.05). Spatial memory and passive avoidance memory in both treated groups significantly decreased compared to the control group (P < 0.05).Conclusion:Carrot consumption, via increases the synthesis of thyroid hormones, creates hyperthyroidism, but due to induced moderate hyperthyroidism did not impact on weight. Moderate hyperthyroidism induced appetite and memory impairment. Then increased food intake or effect of hyperthyroidism on metabolism increased water intake.

Assessment of gene action association involved with economic traits of black carrot (Daucus carota)

Carrots (Daucus carota L.) are rich sources of vitamins, phytonutrients, bioactive compounds and health promotingproperties. Recent increased awareness of nutritional security has resulted in a dramatic increase in carrot consumption,necessitating increased carrot production by farmers and growers. Understanding the genetic design of economictraits including root length, root weight, root diameter, core diameter, and flesh thickness, as well as developing anappropriate breeding plan for these traits, will help accomplish those ambitious goals. Gene action experiments wereconducted at ICAR-Indian Agricultural Research Institute during 2012–15 in order to estimate the type and magnitudeof gene action in order to develop a breeding strategy for recognizing segregants with desirable horticultural traits.Four inbred lines such as Pusa Asita, Pusa Rudhira, Pusa Kulfi, Pusa Meghali were used to develop three crosses, viz.Pusa Asita × Pusa Kulfi, Pusa Asita × Pusa Meghali, Pusa Asita × Pusa Rudhira to achieve the objectives. The findingsconfirmed that the exact composition of gene effects varied through crosses and demonstrated the role of additiveas well as non-additive gene effects in the inheritance of different traits, with a preponderance of the latter. Due tothe parallel function of complementary gene effects, non-epistatic gene interactions for economic yield contributingtraits have been found; thus, hybrid exploitation could be efficiently used by heterosis breeding by using favourablepositive [h] and [l] gene interaction and effects. This genetic information is more helpful to formulate suitable breedingmethodology for identifying the segregants with desirable horticultural traits.

Carrot Consumption Frequency Associated with Reduced BMI and Obesity through the SNP Intermediary rs4445711.

It is unclear whether genetic interactions are involved in the association between vegetable intake and reduced body mass index (BMI) or obesity. We conducted a comprehensive search for single nucleotide polymorphisms (SNPs) which are associated with the interaction between vegetable intake frequency and BMI or obesity. We performed a genome-wide association analysis to evaluate the genetic interactions between self-reported intake of vegetables such as carrot, broccoli, spinach, other green vegetables (green pepper and green beans), pumpkin, and cabbage with BMI and obesity, which is defined as a BMI ≥ 25.0 kg/m2 in the Japanese population (n = 12,225). The mean BMI and prevalence of obesity was 23.9 ± 3.4 kg/m2 and 32.3% in men and 22.1 ± 3.8 kg/m2 and 17.3% in in women, respectively. A significant interaction was observed between rs4445711 and frequency of carrot intake on BMI (p = 4.5 × 10−8). This interaction was slightly attenuated after adjustment for age, sex, alcohol intake, smoking, physical activity and the frequency of total vegetable intake (p = 2.1 × 10−7). A significant interaction was also observed between rs4445711 and frequency of carrot intake on obesity (p = 2.5 × 10−8). No significant interactions that were the same as the interaction between frequency of carrot intake and rs4445711 were observed between the intake frequency of broccoli, spinach, other green vegetables, pumpkin or cabbage and BMI or obesity. The frequency of carrot consumption is implicated in reducing BMI by the intermediary of rs4445711. This novel genetic association may provide new clues to clarify the association between vegetable intake and BMI or obesity.

Switching up sides: Using choice architecture to alter children's menus in restaurants

U.S. children's frequent consumption of restaurant foods has been associated with low vegetable consumption. Use of choice architecture in restaurants has been shown to increase children's orders of healthy sides, but what children consume when healthy sides are included is unknown. The purpose of the present study was to investigate whether altering the choice architecture of children's meals by restructuring the menu, using optimal defaults and vice-virtue bundles, would impact ordering of side dishes and consumption of a vegetable side dish during a restaurant meal. Families with a child between 4-8y attended three dinners at a university-based restaurant. Children's meals included choice of entree (macaroni-and-cheese or chicken tenders) and default side: all carrots (150 g; Menu-1), small fries (50 g)/large carrots (100 g; Menu-2), and small carrots (50 g)/large fries (100 g; Menu-3). Participants could opt-out of the default side for: only fries (Menu-1) or only fries or carrots (Menus-2/3). All foods were pre- and post-weighed to determine consumption. Descriptive statistics examined children's ordering behavior. Repeated measures ANOVA examined differences in consumption of study foods. A paired samples t-test examined differences in french fry consumption (Menus-2/3). Forty-eight children (6.2 ± 1.3 years; 25 male) participated. Most children remained with the default side (Meal-1: 90%; Meal-2: 88%; Meal-3: 85%). Significant differences were seen in children's consumption of french fries (t = −2.57, p = .014) where children ate more during meal 3 compared to meal 2. There were no significant differences in carrot consumption. Use of optimal defaults led to increased orders of healthy sides and steady consumption across the meal conditions. However, use of an optimal, vice-virtue bundle led to a decrease in consumption of french fries. Further investigation of optimal default use on children's menus is warranted.

Clinical and Lifestyle-Related Prognostic Indicators among Esophageal Adenocarcinoma Patients Receiving Treatment at a Comprehensive Cancer Center.

Simple SummaryEsophageal adenocarcinoma (EAC) is a highly lethal cancer with rising incidence in Western countries. Despite diagnostic and therapeutic advances, average 5-year EAC survival remains poor (~20%), with tumor stage and treatment the strongest prognostic factors. The role of lifestyle-related exposures remains uncertain. To address this gap, we analyzed survival associations among EAC patients treated at a tertiary cancer center. Importantly, this study is among the first to assess survival relationships by disease stage for several key lifestyle-related exposures (e.g., physical activity, medications, and diet), enabling us to identify associations which may have been obscured in past analyses. Our findings suggest that lifestyle interventions such as smoking cessation, exercise regimens, and use of cholesterol-lowering (statin) or anti-inflammatory (NSAID) medications may represent promising avenues to improve outcomes in this deadly cancer.Purpose: The incidence of esophageal adenocarcinoma (EAC) has risen substantially in recent decades, while the average 5-year survival remains only ~20%. Disease stage and treatment are the strongest prognostic factors. The role of lifestyle factors in relation to survival remains uncertain, with a handful of studies to date investigating associations with obesity, smoking, physical activity, diet, or medications. Methods: This study included patients diagnosed with primary adenocarcinoma of the esophagus, gastroesophageal junction, or cardia (N = 371) at Roswell Park Comprehensive Cancer Center between 2003 and 2019. Leveraging extensive data abstracted from electronic medical records, epidemiologic questionnaires, and a tumor registry, we analyzed clinical, behavioral, and environmental exposures and evaluated stage-specific associations with survival. Survival distributions were visualized using Kaplan–Meier curves. Cox proportional hazards regression models adjusted for age, sex, stage, treatment, and comorbidities were used to estimate the association between each exposure and all-cause or cancer-specific mortality. Results: Among patients presenting with localized/regional tumors (stages I–III), current smoking was associated with increased overall mortality risk (HR = 2.5 [1.42–4.53], p = 0.002), while current physical activity was linked to reduced risk (HR = 0.58 [0.35–0.96], p = 0.035). Among patients with stage IV disease, individuals reporting pre-diagnostic use of statins (HR = 0.62 [0.42–0.92], p = 0.018) or NSAIDs (HR = 0.61 [0.42–0.91], p = 0.016) had improved overall survival. Exploratory analyses suggested that high pre-diagnostic dietary consumption of broccoli, carrots, and fiber correlated with prolonged overall survival in patients with localized/regional disease. Conclusion: Our data suggest that lifestyle exposures may be differentially associated with EAC survival based on disease stage. Future investigation of larger, diverse patient cohorts is essential to validate these findings. Our results may help inform the development of lifestyle-based interventions to improve EAC prognosis and quality of life.

Association of Dietary Carrot Intake With Bladder Cancer Risk in a Prospective Cohort of 99,650 Individuals With 12.5 Years of Follow-Up.

Previous studies have provided limited evidence for the effect of carrot intake on bladder cancer incidence. This study aimed to evaluate the association between carrot consumption and bladder cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer (PLCO) Screening cohort. PLCO enrolled 154,897 participants between November 1993 and July 2001 from 10 clinical screening centers throughout the United States. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox regression model adjusting for confounders. A meta-analysis was also performed based on all available prospective studies with DerSimonian and Laird random-effects model to calculate summary relative risk (RR) and 95% CI. After a median of 12.5 years of follow-up, 762 incident bladder cancer cases occurred. We found no statistically significant association between dietary carrot intake and bladder cancer risk. The multivariate-adjusted HR of bladder cancer for participants in the highest category of total carrot intake compared with those in the lowest category was 0.96 (95% CI: 0.76–1.22; P for trend = 0.436). Corresponding adjusted HR was 0.98 (95% CI 0.90–1.06) per 1 SD increment of carrot intake. A meta-analysis based on two previous cohort studies and our study also found no significant association between carrot intake and bladder cancer risk (Summary HR 1.02, 95% CI 0.95–1.10) without obvious heterogeneity between studies (P = 0.859, I2 = 0.0%). In summary, analysis of the PLCO cohort did not provide evidence that dietary consumption of carrot was associated with the risk of bladder cancer.