There is a great need for new antibacterial materials. One of the methods of creating such materials is the use of carriers for active substances - antibiotics. One of the potential materials to be used for this purpose are zeolites. In this work, zeolite X with ions exchanged for Ca2+, Mg2+, Sr2+ and Zn2+ was prepared and used as a carrier for an antibiotic from the group of fluoroquinolones - ciprofloxacin. To our best knowledge, so far no one has prepared carriers for this substance based on its interaction with ions. The material was subjected to SEM/EDS analysis, which confirmed the sorption of the drug in the form of a monolayer on the internal pore surface of the zeolites. All materials were able to retain and release the drug, but these processes were dependent on the atomic radius of the ions present in the zeolite. Density functional theory (DFT) calculations were used to elucidate the host-guest interactions in more detail. The bacterial growth in the presence of the materials containing zeolites and antibiotics was inhibited almost completely which proves their antibacterial activity. This material can be used as a filler to create bone scaffolds and as a coating for implants.