Interventional neuroradiology plays an important role in the management of skull base disease in two aspects: endovascular and CT-guided techniques. Endovascular procedures comprise devascularizing as well as recanalizing interventions. Preoperative embolization of vascular tumors (e.g., paraganglioma, angiofibroma) using particles reduces intraoperative blood loss and can even turn inoperable tumors into operable ones. The treatment of dural arteriovenous fistulae is based mainly on endovascular techniques. Contrary to transarterial embolization as in tumors, most fistulae are tackled on the transvenous route using free or detachable coils. In many cases occlusion of the venous side eliminates the goal of the fistula and is the only chance of permanent cure. Treatment of skull base-related aneurysm requires close cooperation between the neurosurgeon and neuroradiologist. Contrary to open surgery, the skull base per se is not an obstacle to endovascular techniques. In the treatment of aneurysms, usually detachable platinum coils are employed with or without the help of stents. Occlusion of the carrier vessel using coils or detachable balloons is a therapeutic alternative in selected cases. Of recanalizing interventions, treatment of vasospasm with endovascular balloon catheters can be a life-saving procedure in the setting of acute subarachnoid hemorrhage. Arteriosclerotic stenoses of basal arteries can be dilated with stent-assisted angioplasty in patients suffering from cerebrovascular symptoms that cannot be managed with medical treatment alone. Of the CT-guided interventions, bioptic techniques of tumors adjacent to the skull base can in some cases substitute for open biopsy.