We have previously shown that bilateral carotid body denervation (CBD) in SHR reduces arterial pressure (AP). How CBD interacts with the more established technique of renal denervation (RDNX) is unknown. Here we test the hypothesis that CBD will lower AP over and above the fall in pressure achieved with RDNX. In 12 week‐old SHR previously instrumented to record AP telemetrically, denervation surgery (unilateral CBD n=6; bilateral CBD n=7; Sham CBD n=6; RDNX n=5; Sham RDNX n=5) was performed on Day 0. On Day 21 after CBD or Day 14 after RDNX, the renal nerves or carotid bodies were denervated respectively. Chemoreflex elimination was confirmed by i.v. sodium cyanide (120ìg.kg‐1; Sham 15±3mmHg, CBD 1±2mmHg). By Day 21 after bilateral CBD, AP was reduced by −17±2 mmHg from a baseline of 160±5 mmHg (p<0.05); unilateral CBD/Sham rats showed the expected developmental increase in AP of 7±2mmHg/9±3mmHg. Subsequent RDNX reduced AP by a further −8±2mmHg in bilateral CBD rats and by −8±3mmHg in Sham rats (p<0.05). Conversely, in RDNX rats (−7±2mmHg), bilateral CBD produced a further fall in AP of −12±3 mmHg(p<0.05). In summary, unilateral CBD alone seems insufficient to reduce AP in SHR. Bilateral CBD and RDNX appear to have an occlusive interaction. This is important clinically as it suggests further reductions in AP may be obtained in hypertensive patients post renal denervation. Supported by the British Heart Foundation and Cibiem.