While previous research has supported the role of ambiguity aversion in the career decision-making process, little is known about the relation between ambiguity aversion and the outcomes of career decision-making. Using a sample of U.S. employees (n = 288), the current study examined the prediction of ambiguity aversion for job and life satisfaction and the mediation of these relations through career decision-making style and perceived person-environment fit. The results support a sequential dual mediator model in which ambiguity aversion negatively predicts job and life satisfaction sequentially through a rational decision-making style and perceived person-environment fit. Additionally, the results support a single mediator model in which ambiguity aversion negatively predicts job and life satisfaction only in perceived person-environment fit. Therefore, the current study demonstrates a ripple prediction of managing ambiguity for the distal outcomes of job and life satisfaction and suggests a relational mechanism. The theoretical and practical implications of this study are discussed together with the limitations and suggestions for future research. (PsycINFO Database Record (c) 2019 APA, all rights reserved).