ABSTRACT This research examined the relationship between spiritual well-being and the career adaptability of Chinese youths in Hong Kong. Cross-sectional data collected from one university consisted of 461 students (204 males, 257 females; ages 19–23). The participants were asked to complete the Spiritual well-being questionnaire (SWBQ) to evaluate the status of their spiritual wellbeing (including the personal and communal, environmental, and transcendental domains) and Career Adapt-Abilities Scale (CAAS) to assess their career adaptability in the areas of concern, control, curiosity, and confidence. The study found that the personal and communal domains of spiritual well-being were positively associated with career adaptability in all domains. Hierarchical Regression analysis also showed that personal and communal domains of spiritual well-being explained 38.5%, 39.6%, 11.2% and 48.7% of the variance in Chinese youth’s concern, control, curiosity and confidence of career adaptability respectively. The personal and communal domain were the strongest predictor of career adaptability.